Báo cáo y học: "dentification of collagen-induced arthritis loci in aged multiparous female mice" potx

... in the first year postpartum the chance of onset is increased [6,7]. The results of a recent study of RA in women, however, indicate that pregnancy his- tory does not increase the incidence of ... group). Finally, the NFR/N strain had not previously been used in linkage analyses for detection of CIA-associated loci, which opened (up) the possibility of detecting new polymor...

Ngày tải lên: 09/08/2014, 07:20

... Ontology (GO) analysis was carried out by using GoMiner, developed by Weinstein and colleagues [35]. Briefly, retrieved gene symbols were input into GoMiner, which maps them onto the GO tree, in ... practically every tissue, they bear rich information regard- ing inflammation and immune responses [23]. Thus, blood – increasingly being recognized as a sentinel tissue – is uniquely suited to...

Ngày tải lên: 09/08/2014, 07:20

... Society of Rheu- matology (DGRh), and the Interdisciplinary Center for Clinical Research (IZKF) of the University of Muenster. References 1. Muller-Ladner U, Gay RE, Gay S: Cellular pathways of ... G 2 / M phase, indicating that the cell population remained highly synchronised. Cell cycle analysis after 42 and 48 hours confirmed an increase of RASFs in G 0 /G 1 phase, indicating...

Ngày tải lên: 09/08/2014, 01:22

... difficulty they experience performing eight activ- ities (dressing, getting out of bed, lifting a cup, walking, bathing, bending, turning faucets, and getting in and out of a car), on a scale ranging from ... upper extremity joint range and dexterity for the shirt button test; and lower limb strength; joint stability; and overall balance for walking velocity. The many-sided quality of...

Ngày tải lên: 09/08/2014, 01:23

... described in proteo- glycan-induced arthritis [8]. On this backdrop the paper by Frey and colleagues represents only a minor blink of an eye in the vast Treg literature, but Frey and colleagues introduce ... role in autoimmunity and more specifically in rheumatoid arthritis (RA) has been highlighted by a string of reports, one of which is in the last issue of Arthritis...

Ngày tải lên: 09/08/2014, 06:23

... pathogenesis of many rodent models of arthritis, including collagen-induced arthritis, antigen-induced arthritis, and adjuvant arthritis, where Th1 cytokines generally predominate early and T helper ... shortly after the onset of symptoms, and the cytokine profile in early disease as determined by immunohistochemistry is nearly identical to long-standing RA [7-9]. The latter f...

Ngày tải lên: 09/08/2014, 06:23

... an inhibitory motif in the cytoplasmic tail and abrogates cellular activation. FcγRIIb may also play a role in maintaining peripheral B cell tolerance and prevention of autoimmunity [8]. Single ... activat- ing and inhibitory FcγRs influences the development of both immune complex-mediated and collagen-induced arthritis [9,10]. Polymorphic variants that increase the expression or...

Ngày tải lên: 09/08/2014, 07:20

... therapeutic standpoint the reversibility of the pathophysiology of destructive arthritis is a key point of inter- est. Since in this model TNF is not only responsible for inflam- matory arthritis but ... Chronic inflammation can lead to sustained alterations of bone turnover, as typically seen in juxta-articular and periarticular damage of inflamed joints in RA. TNF is a p...

Ngày tải lên: 09/08/2014, 07:20

... was similar to that induced by a combination of IL-1/TNF, which might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by S. aureus. S. aureus ... of inducing synthesis of inflammatory cytokines such as IL-1β and TNF-α from host cells [13]. Whether the MMP induction in fibroblasts by S. aureus component(s) is due to the cyto...

Ngày tải lên: 09/08/2014, 08:23

... Because none of the patients had clinical symptoms suggestive of acute PV B19 infection, this finding is highly unlikely. Thus, the specificity of the PV B19 IgM test used in this study must be ... important in determining whether there is a potential risk for developing JRA after acute PV B19 infec- tion. Unfortunately, acute PV B19 infections in this study were diagnosed solely...

Ngày tải lên: 09/08/2014, 10:20