Báo cáo y học: "CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans" ppsx

... cells and lymphocytes. Indeed, CXCL12 is constitutively displayed by endothelial cells (ECs) in the bone marrow and secondary lymphoid organs, where it seems to be produced by nearby osteoblasts, ... SDF-1) is constitutively expressed by stromal resident cells and is involved in the homeostatic and inflammatory traffic of leukocytes. Binding of CXCL12 to glycosaminoglyca...

Ngày tải lên: 09/08/2014, 07:20

... in Cytometry 2003, Suppl 25, Unit 6.4. 29. Khan SS, Solomon MA, McCoy JP: Detection of circulating endothelial cells and endothelial progenitor cells by flow cytometry. Cytometry B Clin Cytom ... systemic sclerosis by flow cytometry with a four-colour panel of antibodies. Statistical analysis was performed with the SPSS 16 statistical package.Circulating endothelial cells were...

Ngày tải lên: 12/08/2014, 14:22

... upregulation induced by HIMF. Stimulation of lung epithelial cells by HIMF resulted in phosphorylation of IKK and IκBα, leading to activation of NF-κB. In addition, HIMF strongly induced Akt phosphorylation, ... (http://creativecommons.org/licenses /by/ 2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. R...

Ngày tải lên: 12/08/2014, 16:20

... amplification by dipyridamole of the anti-inflammatory activity of low-dose prednisolone in this acute model. Figure 1 Synergistic anti-inflammatory activity of prednisolone and dipyridamole in vitroSynergistic ... indicated by histologic analysis [see Figure S2 in Additional data file 1]. In vivo safety assays The observed amplification by dipyridamole of prednisolone anti-inflammatory...

Ngày tải lên: 09/08/2014, 01:22

Ngày tải lên: 09/08/2014, 10:23

... London, London W1P 4JF, UK 2 Biochemical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK Jury and ... presentation or in the absence of stimulation. Agrin is shown in its fully glycosylated (no activation) and modi ed (activation) forms. Also shown is a hypothetical receptor for Agrin exp...

Ngày tải lên: 12/08/2014, 12:20

... cell cycle. To investigate the endothelial response to pneu- monectomy, the lung digests were analyzed by flow cytometry. Baseline analysis by flow cytometry demon- strated 8-15% of the cells ... cell cycle flow cytometry of CD31 + endothelial cells (Figure 2). An early increase in S-phase cells was noted on Day 3 after pneumonectomy. By Day 6 after pneumonectomy, 10% of the...

Ngày tải lên: 12/08/2014, 13:22

... DRF; therefore, this lends support to the hypothesis that these lipids may be used for lipid rafts formation. This hypoth- esis is strengthened by the observation that CD55 signifi- cantly increased ... Lipid analysis was performed by chromatographic techniques, while protein analysis by electrophoresis and Western blotting. Lipid peroxidation was assessed on total plasma membranes...

Ngày tải lên: 12/08/2014, 16:20

... apoptosis suppression by glucocorticoid may be connected to the mechanism of its anti-inflammatory function, and that apoptosis suppression by glucocorticoid in the tissue may also be affected by suppression ... Toshio Yamakawa 1 1 Department of Biochemistry, Faculty of Pharmacy, Tokyo University of Pharmacy & Life Science, Tokyo, Japan; 2 Yoneyama Maternity Hospital, Tokyo, Japan...

Ngày tải lên: 22/02/2014, 07:20

... P85 regulatory subunit of the enzyme and inhibits its catalytic activity. Furthermore, Ruk L overexpression in primary neurons induces apoptosis, which could be rescued by coexpression of constitutively ... lead to its degradation. Based on this study, we propose a possible mechanism for the regulation of Ruk function by ubiquiti- nation. Keywords: signal transduction; adaptor prote...

Ngày tải lên: 17/03/2014, 23:20