Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot

... conditions. Using RNA-interference, Yudoh and colleagues [1] further analyzed the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival. During hypoxic and normoxic ... cell death induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary for anaerobic energy generation and proteoglycan synthesis by...

Ngày tải lên: 09/08/2014, 07:20

... production. This study examined the hypothesis that apoA-I may have a regulatory role at sites of macrophage activation by T lymphocytes in inflamed RA synovial tissue. Synovial tissue samples were obtained ... of inflammatory cells, including monocytes and lymphocytes [1]. It has been proposed that the first cells to infiltrate syn- ovial tissue are T lymphocytes, suggesting th...

Ngày tải lên: 09/08/2014, 01:24

... case report and accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of this journal. Acknowledgements Sylvain Tuaudé, I.S.T CARDIOLOGY for his technical ... 87(3):854-60. 4. Jeon HK, So YK, Yang JH, Jeong HS: Extracorporeal oxygenation support for curative surgery in a patient with papillary thyroid carcinoma invading the trachea....

Ngày tải lên: 10/08/2014, 09:21

... 4 cm enhancing mass at the superior aspect of the left acetabulum extending into the l eft hip joint (Figure 3). There was smooth e rosion of the neck of the femur but the head of the femur appeared ... to the instability of the hip joint. The soft tis- sue swelling responsible for these abnormalities is clearly demonstra ted on the MRI scan (Figure 3). There w...

Ngày tải lên: 11/08/2014, 00:23

... high and constant level of c-Myc. Also, the contribution of Ras/Raf/ERK prevented the rapid degradation of c-Myc by phosphorylation of the serine 62 residue in the N-terminal of c- Myc [24]. They ... hypothesized that c-Myc plays a central role in TGF1 signaling for cell growth stimulation. Additionally, to examine the possibility of involvement of the MAPK...

Ngày tải lên: 09/08/2014, 01:22

... reported on the role of cytokines in RP, either in patients or in the corresponding animal models. In the CIA model, several cytokines have been shown to play major roles in the inflammatory process, ... for the induction of clinical symptoms [16,17]. In addi- tion, the complement system plays a major role in the pathogenesis of both diseases [16,18,19]...

Ngày tải lên: 09/08/2014, 01:24

... as the major energy substrate for articular chondro- cytes and as the main precursor for the synthesis of ECM gly- cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis ... goal of clarifying this role, we documented the ability of HNE to modulate mark- ers of apoptosis, redox status, and energy metabolism of chondrocytes. Then, we inves...

Ngày tải lên: 09/08/2014, 13:21

... disruption of the mucosa barrier, thus provid- ing an easy port of entry and increase the recruitment and activation of HIV susceptible inflammatory cells. The inflammation and ulceration increases ... Institute of General Practice and Community Medicine, University of Oslo, Norway, 2 Department of Obstetric and Gynaecology, Rikshospitalet University Hospital, Uni...

Ngày tải lên: 10/08/2014, 05:20

... of YgfZ followed by Figure 2 Different roles played by YgfZ and SodA in counteracting plumbagin. The ΔygfZ and ΔsodA strains were transformed with pQE- sodA and pQE-ygfZ to express SodA and YgfZ, ... and the Δyg fZ strains and the parental strain were tested (Table 3). Therefore, adding a methyl group to the 3-position of naphtho quinone ring apparently diminishes t...

Ngày tải lên: 10/08/2014, 05:21