Báo cáo y học: "CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase" ppsx

... detection analyses indicated that apoptosis accounted for only a portion of chondrocyte death, whereas the other chondrocytes died by necrosis. Both chondrocyte apoptosis and necrosis depended on ... finding is Figure 3 Chondrocyte death consists of apoptosis and necrosisChondrocyte death consists of apoptosis and necrosis. (a) Morpho- logic analysis of chondrocyte ap...

Ngày tải lên: 09/08/2014, 07:20

... specifically in the grey matter, suggesting that neuronal injury is among the key factors in diffuse NPSLE. This hypothesis is supported by increased levels of neuronal and astrocytic degradation prod- ucts ... years); neuropsychiatric symptoms had been diagnosed one month to 18 years (mean 5 years) before scan- ning. At the time of the study, no active neuropsychiatric symp- toms or any co...

Ngày tải lên: 09/08/2014, 07:20

... suppression of MM12.10 labeling after UIC2 binding) may be intrinsic to the normal catalytic cycle, or, alternatively, the CsA-type drugs may induce a special conformation adopted by Pgp only in ... MM12.10 and UIC2 were prepared as described previously [26,27]. Flow cytometric assays Nearly confluent monolayers of cells were harvested by 2–3 min trypsin treatment [0.05% trypsin and 0.02%...

Ngày tải lên: 08/03/2014, 23:20

... in morning stiffness, type, location and distribution of early symptoms, patients' rated disease activity and C-reactive protein at inclusion between RA patients with and without anti-CCP ... humoral response. Intriguingly, this antibody response may occur years before any clinical symptoms, as shown by the presence of anti-CCP antibodies several years before the clinical onset o...

Ngày tải lên: 09/08/2014, 06:23

... Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: system- atic review and meta-analysis of rare harmful effects in ran- domized controlled trials. ... Chakravarty EF, Genovese MC: Associations between rheuma- toid arthritis and malignancy. Rheum Dis Clin North Am 2004, 30:271-284, vi. 3. Bongartz T, Sutton AJ, Sweeting MJ, Buchan I,...

Ngày tải lên: 09/08/2014, 10:23

... Yuliana, Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; S Oka* and M Honda, International Medical Centre of Japan, Tokyo, Japan; JY Choi* and SH Han, Division ... Hospital and AIDS Prevention and Research Centre, National Yang-Ming University, Taipei, Taiwan; PL Lim*, CC Lee and LC Koh, Tan Tock Seng Hospital, Singapore; P Phanuphak* †, and M Kho...

Ngày tải lên: 10/08/2014, 05:20

... Sayer JM, Long RG: A perspective on iron deficiency anaemia. Gut 1993, 34:1297-1299. 3. McIntyre AS, Long RG: Prospective survey of investigations in outpatients referred with iron deficiency ... hepatectomy was subsequently performed with curative intent, and our patient has now fully recovered. Conclusion: This is a rare example of hemobilia and chronic iron-deficiency anemia in as...

Ngày tải lên: 11/08/2014, 12:20

... regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4- hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhi- bition of ... quality stem from the failure of chondrocytes to maintain a balance between protein synthesis and degradation. Chondrocytes are the only cell type found in mature cartilage, and their d...

Ngày tải lên: 09/08/2014, 13:21

... of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes. Cell Death Differ 1998, 5:183-190. 21. Utz PJ, Anderson P: Posttranslational protein modifications, apoptosis, and the bypass ... cells, prolonged necrosis (primary or secondary), T-cell cytotoxicity asso- ciated with chronic infection, or even antigen mutation or overexpression. It would be important not...

Ngày tải lên: 09/08/2014, 03:24

... high-energy EMF may to some extent compro- mise the biosynthetic activity and/ or function of articular chondrocytes. Although it is known that mechanical stress contributes to the induction of chondrocyte ... impairment. Conclusion A high-energy EMF potentially impairs the biosynthetic activity of articular chondrocytes; this effect is temporary, as shown under the in vitro conditions emp...

Ngày tải lên: 09/08/2014, 08:22