Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps

... (theory of molecular mimicry) [20]. Alternatively, Review Targeting Toll-like < /b> receptor < /b> signaling < /b> in < /b> plasmacytoid < /b> dendritic < /b> cells < /b> and < /b> autoreactive < /b> B cells < /b> as a therapy for lupus Petar S Lenert Assistant ... structures, and < /b> are preferentially recognized by autoreactive < /b> B cells < /b> and < /b> plas...

Ngày tải lên: 09/08/2014, 07:20

... polyclonal antibody (Bio- source International, Camarillo, CA, USA) to detect active Akt kinase, as well as a separate Akt polyclonal antibody (Cell Signaling < /b> Technology, Danvers, MA, USA) to determine ... substrate, Z-Gly-Gly-Arg aminomethyl coumarin (Z-GGR-AMC) was from Bachem (Bubendorf, Switzerland); recombinant human tissue factor from Dade Behring (Marburg, Germany); and <...

Ngày tải lên: 18/02/2014, 16:20

... [3]. As S. cerevisiae is a genetically more tractable yeast than C. albicans, it was chosen as a model fungal system for studying the glyoxylate cycle by analysing the subcellular distribution ... phenotype (Fig. 4A) . To examine whether a cytosolic malate synthase was as ef®cient as a peroxisomal one for m aintaining a functional glyoxylate cycle on oleic acid, liquid g...

Ngày tải lên: 22/02/2014, 04:20

... sample was duplicated and < /b> averages of the absorbance were used in < /b> comparisons. The differences in < /b> absorbance between treated and < /b> untreated samples was shown as relative cell viability. Reverse transcription ... statistics and < /b> clinical data for the SLE patients are described in < /b> Table 1. Preparation of PBMCs and < /b> pDCs Blood samples obtained fr...

Ngày tải lên: 09/08/2014, 10:23

... Doi H, Yoshida A, Yamana J, Yamamura M, Ninomiya Y,< /b> Inoue H, Asahara H: Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in < /b> mice via regulation of p16INK 4a and < /b> p21(WAF1/Cip1) ... or phenylbutyrate inhibits gene and < /b> protein induction of matrix metalloproteinases and < /b> aggrecan-degrading enzymes (ADAMTS) induced by IL-1β and < /b>...

Ngày tải lên: 09/08/2014, 11:20

... oxygen and < /b> epinephrine. Radiolabelled GABA and < /b> baclofen were used for receptor < /b> studies of GABA and < /b> GABA B receptors respectively and < /b> Real Time PCR analysis using specific probes for GABA B receptor < /b> ... used. GABA B Receptor < /b> Binding Assay [ 3 H] baclofen binding to the GABA B receptor < /b> was assayed in < /b> Triton X-100 tre...

Ngày tải lên: 10/08/2014, 05:21

... MITF. It has been reported that several signaling < /b> pathways are involved in < /b> regulating melanin synthesis. The extra- cellular signal-regulated kinase (ERK) signaling < /b> pathway induces the inhibition ... (Alabaster, AL, USA); LY294002 and < /b> rapamycin were from Cell Sig- naling Technology (Beverly, MA, USA). Fetal bovine serum (FBS) was obtained from Hyclone (Logan, UT, U...

Ngày tải lên: 10/08/2014, 10:20

... perimeter airway was quantified as a measure of goblet cell hyperplasia (GCH), a major pathological feature of asthma GCH was significantly increased in < /b> ova challenged animals versus saline controls ... stimuli isadiagnosticandpathologicalfeatureofasthmathat can be recapitulat ed in < /b> animal models of allergic airway inflammation, and < /b> has been linked to increased airw...

Ngày tải lên: 12/08/2014, 11:22

... weekly for all participants: fat free mass, body fat, BMI, extracellular/intracellular water, total body water and < /b> basal metabolic rate. For part of participants blood chemistry parameters and < /b> circulating ... sixty-five years old. The lone male was forty years old. Assay methods are described below. Body composition Body composition was measured by bioelectrical impe...

Ngày tải lên: 25/10/2012, 10:51

Ngày tải lên: 21/06/2014, 04:20