Báo cáo y học: "dentification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model" doc

... facilitate the devel- opment of novel treatments for RA. In the present study we described a noninvasive strategy to discover RA biomarkers by transcript profiling of peripheral circulating lymphocytes. ... approximately 12 days after the first CII immunization. By day 21 the inflam- matory response in the ankles has reached its peak, and by day 28 there is signifi...

Ngày tải lên: 09/08/2014, 07:20

... FC: Analysis of the synovial cell infil- trate in early rheumatoid synovial tissue in relation to local dis- ease activity. Arthritis Rheum 1997, 40:217-225. Arthritis Research & Therapy Vol ... In many chronic inflammatory dis- eases, infiltration of the target tissue by blood- derived cells precedes tissue damage. For example, it is believed that in rheumatoid arth...

Ngày tải lên: 09/08/2014, 01:24

... irrespective of gender and therapy. These stimulated, cen- tral enzyme pathways can be inhibited by administration of the two androgens ASD and testosterone. This study provides a further rationale ... consent. The study was approved by the Ethics Committee of the University of Regensburg, Germany. Basic clinical and laboratory data are given in Table 1. Parameters such as...

Ngày tải lên: 09/08/2014, 06:23

... dTHP-1 cells, monocytes/macrophages from synovial fluid of rheumatoid arthritis patients or from peripheral blood of healthy humans) were measured by flow cytometry using fluorescein isothiocyanate-labeled ... and healthy peripheral blood were analyzed by flow cytometry. The levels of CD147, MMP-2 and MMP-9 mRNA in FLS were detected by RT-PCR. The role of C...

Ngày tải lên: 09/08/2014, 07:20

... either by over- expression of HDAC2 or by theophylline-induced enhance- ment of HDAC activity, indicating that strategies aimed at restoring HDAC activity may enhance the efficacy of GC therapy ... pathways Activation of JAK kinases and subsequent stimulation of transcriptional activity of the STAT family of transcription factors is one of the main signaling pathways...

Ngày tải lên: 09/08/2014, 11:20

... Controlled Study of Patients Receiving Infliximab for Treatment of Rheumatoid Arthritis of Early Onset; ASSURE = Abatacept Study of Safety in Use with Other Rheumatoid Arthritis Therapies; ATTRACT ... part, by the Guidance Document for Development of New Therapies for Treatment of RA, which was issued by the US Food and Drug Administration (FDA) and finalized in 19...

Ngày tải lên: 09/08/2014, 01:22

... University of Pennsylvania Alumni study [12] and Stanford University Staff used as controls in the Stanford Runners study [13]. The University of Pennsylvania Alumni study comprised 23,414 Disability ... specifically by the HAQ: dressing and grooming, arising, eating, walking, hygiene, reach, grip, and common daily activities. For each of these domains, patients report the amo...

Ngày tải lên: 09/08/2014, 01:24

... However, it is very different from the only other study of similar size, a metaanalysis of 14 published studies of HLA-DRB1 Commentary HLA-DRB1 genes and extraarticular rheumatoid arthritis Jean ... and the DRB1*0401/0401 genotype with Felty’s syndrome. The main strength of the Turesson study is its very large recruitment of patients with extraarticular RA and controls...

Ngày tải lên: 09/08/2014, 07:20

... biological themes with the use of the GO tool EASE [36]. The results of the EASE analysis (Table 2) show that the overrepresentation of adi- pocytes detected in the staining analysis is confirmed by the gene ... identified by gene expression analysis and confirmed by histochemistry as not being suitable for the anal- ysis of synovial inflammation because of tis...

Ngày tải lên: 09/08/2014, 07:20

... performed the experiments. AS participated in the design of the study and wrote the manuscript. JRK and PEL partici- pated in the design of the study. HS-K participated in the design of the study and ... RA patients. The median (range) age of the patients at time of the analysis was 63 years (17–81 years), and 76% were female. A cohort of 171 healthy individu...

Ngày tải lên: 09/08/2014, 07:20