Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf

... same joint in both hands) were affected. Our findings suggest that there may indeed be a relationship between the VDR ApaI and TaqI polymorphisms and the risk of symmetrical hand OA in Finnish ... subset of hand OA in women [28,35-37], with three major determinants of the pattern of polyarticular involve- ment being symmetry, clustering by row, and clustering by ra...

Ngày tải lên: 09/08/2014, 07:20

... encephalitis and murine lupus [2]. It has been demonstrated that patients with SLE have a lower level of 25 hydroxyvitamin D3 than do healthy controls [3]. In addition, high-dose 1,25-dihydroxyvitamin D3 ... of 1,25-dihydroxyvitamin D3 are mediated through its nuclear receptor (VDR). The VDR regulates gene transcription by binding to the hexameric core binding motif in promot...

Ngày tải lên: 09/08/2014, 07:20

... asso- ciated rapid response steroid binding receptor (MARRS) [8]. Certain polymorphisms of the VDR gene may modify vitamin D function and metabolism and have been exam- ined in studies evaluating the ... sclerosis (MS) and osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS...

Ngày tải lên: 11/08/2014, 07:21

... lengths of ICU and hospital stay were respectively 5.4 ± 4.9 days (range, 0 to 47 days) and 10.7 ± 14 days (range, 0 to 142 days). Lengths of ICU (6 ± 5.4 days vs. 3.8 ± 2.5 days) and hospital stay ... Rebleed- ing was defined as the persistence and/ or the recurrence of bleeding after treatment. Early-onset rebleeding was defined as occurring within the first 30 days, and late...

Ngày tải lên: 12/08/2014, 15:20

... (CD80, CD86, and CD40), and the maturation proteins (CD1a and CD83) [7]. In addition, the antigen-presenting capacity of macrophages and dendritic cells is suppressed and the immune stimulatory interleukin-12 ... performed interpretation of data and manuscript preparation. JG, MZ, and GS performed interpretation of data and drafted the manu- script. JK, LC, and EG pe...

Ngày tải lên: 09/08/2014, 13:22

... 1-hydroxylase), which modulates the output of the D steroid by the kidney [7]. Vitamin D hormone and the immune response In recent years, the discovery of the VDR in the cells of the immune system and the fact ... progressed into CTDs had lower vitamin D levels than those who remained in the UCTD stage and UCTD most frequently progressed into RA, SLE, Sjögren’s syndrom...

Ngày tải lên: 09/08/2014, 13:22

... military personnel during training, no study has investigated changes in vitamin D status in Soldiers during Uni- ted States (US) Army basic combat training (BCT). This longitudinal study aimed to determine ... determine the effects of BCT on 25-hydroxyvitamin D (25(OH )D) and parathyroid hormone (PTH) levels in female Soldiers. Serum 25(OH )D and PTH were assessed in 74 fa...

Ngày tải lên: 11/08/2014, 23:21

... time indicated by the arrow in (a). (a) Density plots of the rate of CD62L shedding in each cell population, as indicated by decreased binding of anti- CD62L FITC . (b) Corresponding levels of ... stained with a combination of CD4 APC , CD4 CYCHROME , CD4 PE , CD8 APC , CD8 CYCHROME , CD8 PE , CD8 FITC and CD62L FITC antibodies (Becton Dickinson, Oxford, UK) as indicated, wa...

Ngày tải lên: 09/08/2014, 06:22

... IMA and PAK conceived of the study, participated in its design and coordination and helped in prepara- tion of the manuscript. All authors read and approved the final manuscript. Acknowledgements This ... 373:1905-1917. 20. Adenuga D, Rahman I: Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of...

Ngày tải lên: 11/08/2014, 03:20

... designed and ran the in vivo model. KFC participated in the study design and preparation of the manuscript. IMA and PAK conceived of the study, participated in its design and coordination and ... Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and increased protein expression of Mi2β may lead to altered gene repression....

Ngày tải lên: 11/08/2014, 06:22