Báo cáo y học: "Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice" pps

... following collagen antibody-induced arthritis inductionReduced severity of arthritis in poly(ADP-ribose) polymerase (PARP)-1 deficient mice and PARP-1 sufficient mice following collagen antibody- induced ... induced to a similar extend in Figure 4 Representative hematoxylin-eosin stained sections of knee joints in mice with collagen antibody-induced arthritis (CAIA)R...

Ngày tải lên: 09/08/2014, 07:20

... naturally occurring cells specific for self proteins or they may be induced by feeding a protein. From preliminary studies, we have results that support this suggestion, since we have seen that injection ... = collagen type II; CIA = collagen- induced arthritis; ELISA = enzyme-linked immunosorbent assay; IFN = interferon; IL = interleukin; OVA = ovalbumin; PBS = phosphate-buffered saline;...

Ngày tải lên: 09/08/2014, 01:23

... strain B10.Q normally show a very low incidence of arthritis (around 15%). The female predominance in incidence of CIA makes polymorphic genes in the congenic fragment particularly interesting since female ... protein kinase kinase 6 Abnormal immune system Sox9 112.643538 – 112.649074 SRY-box containing gene 9 Perinatal lethality, cartilage formation, sex reversal a Polymorfism between...

Ngày tải lên: 09/08/2014, 10:23

... necessity of TNF recept receptrecept receptors in bleomycin ors in bleomycinors in bleomycin ors in bleomycin- -induced lung injury in mice induced lung injury in miceinduced lung injury in mice induced ... CCAAT/enhancer binding protein beta in bleomycin CCAAT/enhancer binding protein beta in bleomycinCCAAT/enhancer binding protein beta in bleomycin CCAAT/enhancer bin...

Ngày tải lên: 12/08/2014, 14:20

... A, alanine; L, leucine; T, threonine; Y, tyrosine; εACA, ε-aminohexanoic acid-lysine-lysine- tyrosine-glycine-OH. b Absorbance at 405 nm in ELISA tested with affinity-purified mAbs. In the ELISA ... were in native triple-helical form. Amino acids are abbreviated as follows: G, glycine; P, proline; B, hydroxyproline; E, glutamic acid; R, arginine; K, lysine; H, histidine; F, phenylala...

Ngày tải lên: 09/08/2014, 07:20

... allele-frequency spectrum to 1% (by genotyping more individuals), and extend the project to other continental populations (by genotyping individuals of different ancestries). High-throughput genotyping ... 156 were previously unknown. In an association study using allele-frequency estimates, the authors then identify two low-frequency SNPs in the IFIH1 gene that confer protection from t...

Ngày tải lên: 14/08/2014, 21:20

... described above. Cytokine expression from draining lymph node cells Inguinal draining lymph nodes were removed from mice on day 40 after immunization. Incisions were made in the lymph nodes and ... determined at 3.6 ml, 3.1 ml and 3.4 ml for the pGTRTT plus doxycy- cline, pGTRTT without doxycycline, and pGTRTEmpty plus doxycycline treatment groups, respectively. The average amount of doxycy...

Ngày tải lên: 09/08/2014, 01:23

... macrophages, leading to the production of proinflammatory cytokines. Indeed, there are reports indicating that fibroblasts and mono- cytes can be activated by granzyme A to secrete the proinflam- matory cytokines ... that arthritis developed only with reduced inci- dence, severity and delayed onset in pfp -deficient DBA/1J mice. These findings suggest that pfp-dependent cytotoxicity is i...

Ngày tải lên: 09/08/2014, 06:23

... to an increase in airway responsiveness in mice. Mice exposed to Cl 2 showed increases in total inflammatory cells, in particular neutrophils and lym- phocytes. Despite lack of incr eases in nitrate/nitrite ... Lavoie 1 , Ju Jing Tan 1 , James G Martin 1* Abstract Background: Exposure to chlorine (Cl 2 ) causes airway injury, characterized by oxidative damage, an influx of inflammat...

Ngày tải lên: 12/08/2014, 11:22

... within 15 min of dosing with threo- hydrobupropion HCl 75 mg/kg, and four mice and one mouse within 30 min and 45 min, respectively, of dosing with hydroxybupropion HCl 75 mg/kg. In addition, clin- ical ... liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice, namely erythrohydrobupropion...

Ngày tải lên: 08/08/2014, 23:21