Báo cáo y học: "Polarized subsets of human T-helper cells in

Báo cáo y học: "Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts" doc

... by Th2 cells were affected strongly by both U-0126 and PSI and weakly by the JNK inhibitor (Fig- ure 6a,c). Finally, IP-10 mRNA levels induced by Th1 cells were decreased by U-0126 and PSI, and ... preferen- tially by Th1 cells and IL-8 mainly by Th2 cells, whereas MCP- 1 is induced equally by both subsets. This illustrates the capacity of fibroblasts to ac...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Early Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages" ppsx

... of Btk and phosphorylation of two sites (Tyr 551 and Tyr 223). Tyr 551 is situated in the activation loop and its phosphorylation may be initiated by SFK, leading to autophosphorylation of Tyr ... phosphorylation of ERK and p38 (Fig. 6C), neither did it affect the zymosan- induced phosphorylation of PLCγ2 (Fig. 6B). A partial inhibition of the phosphorylation of Akt in...

Ngày tải lên : 11/08/2014, 08:21

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Báo cáo Y học: S-Decyl-glutathione nonspeciﬁcally stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) ppt

... activity of GST- and MBP-NBD1 was stimulated by S-decyl glutathione: approximately twofold at 250 l M of S-decyl-glutathione (Fig. 2). Up to 250 l M of S-decyl-glutathione, the stimulatory action increased, ... was efﬁciently inhibited by ortho- vanadate (IC 50 ¼ 10 l M ), less efﬁciently by N-ethylmalei- mide (IC 50 ¼ 0.5 m M ), and hardly by sodium azide (IC 50 >6m M )...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo y học: "Platelet-Activating Factor Antagonists Decrease Follicular Dendritic-Cell Stimulation of Human B Lymphocytes" pptx

... as expressed by incorporation of [ 3 H]- thymidine. Upper panel shows assessment of mixed tonsillar B lymphocytes( n = 4); lower panel shows assessment of low-density tonsillar B lymphocytes The gray and ... appearance of spindle-shaped adherent cells in culture and stained negatively for CD20 and CD3 and positively for CD14 and VLA-4 by flow cytometry (data not shown)...

Ngày tải lên : 08/08/2014, 20:23

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Báo cáo y học: "Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes" pdf

... of human MMP-13 by licofelone, an inhibitor of cyclooxygenases and 5-lipoxygen- ase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signaling pathway. ... inflammatory factor, and the IL-1β-induced catabolic factors, and (ii) by promoting the production of the cartilage specific macromolecule collagen type II. Thus, data from...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: "Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer" pps

... separated by the proximity of the cells to the joint space and the bone respectively, alignment of the chondrocytes along the arcades of Benninghoff [29] and by the appearance of hypertrophic cells. ... chondrogenesis of primary MSCs and to investigate whether levels and extent of hypertrophy in vitro is influenced by the choice of transgene. Materials and m...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: "A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes." ppsx

... syndrome and other human aneuploidy disorders. Background Aneuploidy refers to an abnormal copy number of genomic elements, and is one of the most common causes of morbidity and mortality in humans ... into cardiomyocytes, and myeloid and neuronal lineages, which represent cell types/tissues affected by DS. The detection of early changes, at the level of undifferentia...

Ngày tải lên : 09/08/2014, 20:22

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Báo cáo y học: "Phase delaying the human circadian clock with a single light pulse and moderate delay of the sleep/dark episode: no influence of iris color" potx

... radioimmunoassayed for melatonin. The sensitivity of the assay was 0.7 pg/ml and the intra- and inter-assay coefficients of variability were 12.1% and 13.2%, respectively. Data Analysis To determine ... suppression by recent photic history. J Clin Endocri- nol Metab 2004, 89:3610-3614. 35. Chang A, Scheer FA, Czeisler CA: Adaptation of the human circadian system by prior l...

Ngày tải lên : 10/08/2014, 09:20

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Báo cáo y học: " Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors" pps

... Stinski MF: Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides. J Virol 1978, 26:686-701. 22. Vieira J, Schall TJ, Corey L, Geballe AP: ... Mori S, Hamaki T, Kusumi E, Miyakoshi S, Nannya Y, Chiba S, Arai Y, Mitani K, Hirai H, Mutou Y: Monitoring cytomegalovirus infection by antigenemia assay and two distinct...

Ngày tải lên : 11/08/2014, 21:21

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Báo cáo y học: "Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams"

... Interestingly, in that study, 17.8% of all recordings of early signs and 9% of late signs were judged by nurses to be ‘usual for the patient’. These commonly included mild hypoxaemia, hypercarbia, and hypotension. ... activation. We do not know about the anthropology and psychology of how nurses and doctors currently respond to changes in patient status and why they do or...

Ngày tải lên : 25/10/2012, 10:35

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