Báo cáo y học: "steoclasts; culprits in inflammatory osteolysis" doc
Báo cáo y học: "steoclasts; culprits in inflammatory osteolysis" doc
... inflammatory
arthritis. Interestingly, c-Fos overexpression in α
v
β
3
-deficient
osteoclasts substantially rescues the cells’ capacity to
organize their cytoskeleton [28]. In contrast, the integrin ... bone in an inflammatory
environment has provided new therapeutic targets that are
now being assessed in clinical trials.
Competing interests
The author(s) declare that they have no...
Báo cáo y học: "Mast cells in inflammatory arthritis" pdf
... functionally modulate the course of inflammatory
arthritis.
Mast cells and the synovial mesenchyme
The synovial mesenchyme, consisting principally of
synovial fibroblasts, is prominently involved in joint
inflammation. ... via
TLRs by synovial constituents with TLR ligand activity,
including heat shock protein 60 and breakdown products
of hyaluronan, potentially amplifying any inflammato...
Báo cáo y học: "Outcome measures in inflammatory rheumatic diseases" pdf
... Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van
der Linden S: Assessments in Ankylosing Spondylitis Working
Group. Preliminary core sets for endpoints in ankylosing
spondylitis. J Rheumatol ... (SDAI)
and ankylosing spondylitis (Bath Ankylosing Spondylitis
Disease Activity Index (BASDAI)), but also for systemic lupus
erythematosus (Systemic Lupus Erythematosus Disease
Activity Inde...
Báo cáo y học: "Homing chemokines in rheumatoid arthritis" doc
... important in retaining
the cells at this site [17,18].
In about 20% of patients with RA, infiltrating T and B lym-
phocytes accumulate underneath the synovial lining layer
and organize into lymphocyte ... highly dif-
ferentiated state [11–16]. These inflammatory
chemokine receptors are prominently expressed on
effector T lymphocytes (Th1 cells) that mediate a type 1
inflammation such as...
Báo cáo y học: "Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study" pps
... changes in
HAAP include marked proliferation of synoviocytes in the
synovial lining layer, gross infiltration of lymphocytes, and
migration of atypical lymphocytes with nuclear indentation
into ... osteophytes and definite joint space narrowing.
b
Scoring was as follows: +/-, minimum staining in one area of the
tissue; +, patchy staining involving several areas; ++, moderate diffuse s...
Báo cáo y học: "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANK" pps
... RANK/
RANKL in inflammatory cells, in inflamed synovium, in artic-
ular cartilage and at the invading front of bone erosions.
It has been long recognized that pro -inflammatory
cytokines are intimately ... staining for RANKL in synovial
cells and in the infiltrating (inflammatory) cells (Fig. 4h).
There was a marked increase in RANKL expression, con-
sistent with the increase...
Báo cáo y học: "Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells" pps
... vessels in the highly vascular
endothelium expressed CCL5 protein (Figure 6). In addition,
staining was demonstrated at the synovial lining and on many
infiltrating inflammatory cells.
Protein levels ... on inflammatory T
cells from the joint in JIA [18]. mRNA coding for both CCL3
and CXCL10 was readily detected in both the inflammatory
cells from the joint (SFMCs) of children w...
Báo cáo y học: " Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies" doc
... tissue are highly similar in chronic
inflammatory myopathies, suggesting that some molecular
pathways are shared between the subsets of inflammatory
myopathies.
In the inflammatory myopathies there ... distinct sublineages and
are cytotoxic cells working in a perforin/granzyme-dependent
manner; interestingly, CD4
+
lymphocytes can sometimes also
display cytotoxic effector function...
Báo cáo y học: "Increased lymphangiogenesis in joints of mice with inflammatory arthritis" pptx
... of various cell types that produce a vast
array of inflammatory mediators, including cytokines and
chemokines that destroy the extracellular matrix in the joint by
direct and indirect mechanisms. ... neovascularization,
inflammatory cell infiltration, and concomitant synovial cell
hyperplasia, the volumes of the synovium and synovial fluid
increase, resulting in joint swelling and pai...
Báo cáo y học: "Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB" ppsx
... with a reduction in the circulating pro-
inflammatory markers and an increase in those anti-
inflammatory cytokines; these effects result in a benefit
on the myocardial inflammatory process associated ... captopril in SHR.
Abbreviations
ACE: angiotensin converting enzyme; IL-1β: interleukin-1β; IL-6: interleukin-6;
SHR: spontaneously hypertensive rats; WKY: Wistar Kyoto rats; AT...