Báo cáo y học: "steoclasts; culprits in inflammatory osteolysis" doc

... inflammatory arthritis. Interestingly, c-Fos overexpression in α v β 3 -deficient osteoclasts substantially rescues the cells’ capacity to organize their cytoskeleton [28]. In contrast, the integrin ... bone in an inflammatory environment has provided new therapeutic targets that are now being assessed in clinical trials. Competing interests The author(s) declare that they have no...

Ngày tải lên: 09/08/2014, 07:20

... functionally modulate the course of inflammatory arthritis. Mast cells and the synovial mesenchyme The synovial mesenchyme, consisting principally of synovial fibroblasts, is prominently involved in joint inflammation. ... via TLRs by synovial constituents with TLR ligand activity, including heat shock protein 60 and breakdown products of hyaluronan, potentially amplifying any inflammato...

Ngày tải lên: 09/08/2014, 01:24

... Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van der Linden S: Assessments in Ankylosing Spondylitis Working Group. Preliminary core sets for endpoints in ankylosing spondylitis. J Rheumatol ... (SDAI) and ankylosing spondylitis (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)), but also for systemic lupus erythematosus (Systemic Lupus Erythematosus Disease Activity Inde...

Ngày tải lên: 09/08/2014, 14:22

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... highly dif- ferentiated state [11–16]. These inflammatory chemokine receptors are prominently expressed on effector T lymphocytes (Th1 cells) that mediate a type 1 inflammation such as...

Ngày tải lên: 09/08/2014, 03:24

... changes in HAAP include marked proliferation of synoviocytes in the synovial lining layer, gross infiltration of lymphocytes, and migration of atypical lymphocytes with nuclear indentation into ... osteophytes and definite joint space narrowing. b Scoring was as follows: +/-, minimum staining in one area of the tissue; +, patchy staining involving several areas; ++, moderate diffuse s...

Ngày tải lên: 09/08/2014, 01:23

... RANK/ RANKL in inflammatory cells, in inflamed synovium, in artic- ular cartilage and at the invading front of bone erosions. It has been long recognized that pro -inflammatory cytokines are intimately ... staining for RANKL in synovial cells and in the infiltrating (inflammatory) cells (Fig. 4h). There was a marked increase in RANKL expression, con- sistent with the increase...

Ngày tải lên: 09/08/2014, 06:22

... vessels in the highly vascular endothelium expressed CCL5 protein (Figure 6). In addition, staining was demonstrated at the synovial lining and on many infiltrating inflammatory cells. Protein levels ... on inflammatory T cells from the joint in JIA [18]. mRNA coding for both CCL3 and CXCL10 was readily detected in both the inflammatory cells from the joint (SFMCs) of children w...

Ngày tải lên: 09/08/2014, 07:20

... tissue are highly similar in chronic inflammatory myopathies, suggesting that some molecular pathways are shared between the subsets of inflammatory myopathies. In the inflammatory myopathies there ... distinct sublineages and are cytotoxic cells working in a perforin/granzyme-dependent manner; interestingly, CD4 + lymphocytes can sometimes also display cytotoxic effector function...

Ngày tải lên: 09/08/2014, 10:20

... of various cell types that produce a vast array of inflammatory mediators, including cytokines and chemokines that destroy the extracellular matrix in the joint by direct and indirect mechanisms. ... neovascularization, inflammatory cell infiltration, and concomitant synovial cell hyperplasia, the volumes of the synovium and synovial fluid increase, resulting in joint swelling and pai...

Ngày tải lên: 09/08/2014, 10:21

... with a reduction in the circulating pro- inflammatory markers and an increase in those anti- inflammatory cytokines; these effects result in a benefit on the myocardial inflammatory process associated ... captopril in SHR. Abbreviations ACE: angiotensin converting enzyme; IL-1β: interleukin-1β; IL-6: interleukin-6; SHR: spontaneously hypertensive rats; WKY: Wistar Kyoto rats; AT...

Ngày tải lên: 11/08/2014, 03:20