Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx
Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx
... RA. As a group, they are the major actors in the degradation of ECM in RA cartilage and bone. In addition, they increase and perpetu- ate joint inflammation through the activation of cytokines, chemokines ... (PLAT) [17] and plasminogen activator inhibitor-1 (PAI-1) [18]. They were selected as appropriate candidates to participate in RA sus- ceptibility and studied in a...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo khoa học: "Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study" ppsx
... head and neck as well as total body irradiation. A median thyroid dose in Bonato et al.’ s study was 42 Gy (inter-quartile range: [27-72Gy]) [15]. After high-dose radiotherapy the 5 years incidence ... (forward) planning. The photon beams energy was 6 MV using a Varian Clinac (Varian Medical Sys- tem) linear accelerator. The dose plans were normali zed to the mean dose to the plan...
Ngày tải lên: 09/08/2014, 09:20
Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... enzymes, such as cytochrome P450s. All activated carcinogens can bind to DNA and form DNA adducts that are capable of inducing muta- tions and initiating carcinogenesis. The capacity to repair ... (SNPs) in candidate genes, among which DNA repair genes are increasingly being studied. Genetic variations in DNA repair genes are thought to modulate DNA repair capacity an...
Ngày tải lên: 31/10/2012, 14:59
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
... Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K: Functional haplotypes of PADI4, encoding ... and interpretation of data, manuscript preparation, and statistical analysis. IDV was responsible for analysis and interpretation of data, manuscript preparation, and statistical...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage" pdf
... Vector Lab- oratories Inc., Burlingame, CA, USA) and then incubated with Vectastain ABC-AP kit (AK-5000; Vector Laboratories Inc.) for 30 minutes at room temperature. Finally, sections were stained ... determined by quantitative polymerase chain reaction in eight normal (mean age: 20.3 years, range: 19 to 37 years; Mankin score: 0 to 2 points) and eight OA (mean age: 57 years, ra...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: " Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan" ppt
... for the integrity of the data and the accuracy of the data analysis. Study concept and design: CJC, LIH. Acquisition of data: CJC, LIH, WPC, YHC, WCL. Analysis and interpretation of data: CJC, ... primer (5’-CAA CTT CAT CCA CGT TCA CC-3’ and 5’-GAA GAG CCA AGG ACA GGT AC-3’) in a multiplex polymerase chain reaction (PCR). PCR was performed in a total volume of 100 μL, containi...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG" pdf
... L, Maly FE, Zünd G, Turina M: Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass. ... risk stratification. Background Coronary artery disease (CAD) is a multifactorial disor- der, accounts for roughly one-half of all cardiovascular deaths, and is a major cause of morbidit...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1β stimulated fibroblast-like synoviocytes" doc
... concentration, TauCl may remain at a high concentration in extracellular fluids because the intracellular and extracellular concentrations of taurine in mammalian tissues are 10 to 70 mmol/l and 20 to 100 ... various proinflammatory mediators. Among these factors, NF-κB is a key regulator of inflammatory gene transcription, and it is known to be activated in RA syno-...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications" doc
... [10]. Inflammatory cytokines and insulin resistance Inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) can induce insulin resistance and suppression of Glut4 expression by inhibiting insulin ... the understanding of MetS. The insulin receptor has an intrinsic tyrosine kinase activity. Binding of insulin to its receptor induces both autophosphorylation and phosphorylation...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Primary congenital anomalies of the coronary arteries and relation to atherosclerosis: an angiographic study in Lebanon" doc
... Lebanon Email: Ali H Eid* - alieid@uaeu.ac.ae; Ziad Itani - z.itani@hotmail.com; Mohammad Al-Tannir - mohamad.tannir@yahoo.com; Said Sayegh - said_sayegh@yahoo.com; Ali Samaha* - ali.samaha@liu.edu.lb * ... LCX arising as early branch of Right Coronary Artery (RCA), left anterior descending coronary artery (LAD) arising from right coronary sinus, RCA arising from left coronary sinus, and a...
Ngày tải lên: 10/08/2014, 10:20