Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

... immune-modulatory potential. Five statins are currently available within the UK: pravastatin, simvastatin, fluvastatin, atorvastatin and rosuvastatin; in addition, lovastatin is available in other countries. ... derivatives, whereas fluvastatin, atorvastatin and rosuvastatin are entirely synthetic [1]. Lovastatin and simvastatin are of the lactone Review Do the pleiotropic e...

Ngày tải lên: 09/08/2014, 06:22

... 6 Research article Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation ... the assays and wrote the manuscript. AK (Allard Kaptein) helped in conceiving the study and helped to draft the manuscript. AK (Annemiek...

Ngày tải lên: 09/08/2014, 07:20

... incubated by an alkaline phosphatase conjugated rabbit anti-rat immu- noglobulin (Dako) and the reaction was visualized using a rat alkaline phosphatase–antialkaline phosphatase complex (Dako), ... USA). Statistical analysis Data are expressed as mean ± standard error of the mean. Expression of ERK, p38MAPKα and JNK in the different ther- apy groups and cell types was co...

Ngày tải lên: 09/08/2014, 07:20

... to assess efficacy. Application of such auto- mated radiogrammetry to the existing clinical trial data (such as these hand X-rays) offers an opportunity to examine the effects of TNF blockade ... months, Kalla and colleagues [12] reported significant effects on metacarpal cortical width with sulphasalazine, antimalarials and injectable gold. Of interest, the manual technique...

Ngày tải lên: 09/08/2014, 10:20

... produced at high levels by macrophages localized in the lining layer and at the pannus lesion, induce the synthesis of numerous inflamma- tory mediators and matrix-degrading enzymes via the activa- tion ... infiltration of inflammatory cells, primarily lym- phocytes, and macrophages and proliferation of synovial fibroblasts, together with increased vascularity. Macroph...

Ngày tải lên: 09/08/2014, 07:20

... inhibitor inter-α-inhibitor, and thereby increases its anti-plasmin activity. This suggests a role for TSG-6 in the regulation of the plasmin/plasminogen acti- vator system and therefore the control of ... transcription system. The recombinant RNA was quantified by the measurement of A 260 and used as a standard (after cDNA synthesis) in the quantitativ...

Ngày tải lên: 09/08/2014, 01:22

... putative AGA sera and normal control sera were obtained from the laboratory serum bank and Advanced Diagnostics Laboratory at the University of Calgary, Canada. Some AGA sera were also provided by Drs ... of the five antigens, five had antigiantin and antigolgin-245, two had antigiantin and antigolgin- 160, two had antigiantin and anti-GM130, two had anti- giantin and an...

Ngày tải lên: 09/08/2014, 01:23

... cells and human fibroblasts, as well as by gel zymography and an invasion assay. Significantly elevated release and activation of MMP-9 and/ or MMP-2 were seen in the co-culture of human monocytes/THP-1 ... participated in the design of the study and drafted the man- uscript. JD carried out the flow cytometry assay and the chem- otaxis assay, performed th...

Ngày tải lên: 09/08/2014, 06:23

... patients in the late stages of OA, an increase in staining intensity was found in the pericel- lular space (Figure 4b). In healthy cartilage, COMP staining was also found in the territorial and ... joints. One sample, with a macroscopically normal appearance, was taken from the lat- eral aspect of a condyle. The other one was taken from the area adjacent to th...

Ngày tải lên: 09/08/2014, 07:20

... analysis and interpretation of data, statistical analysis, and manuscript preparation. NA participated in acquisition of data, analysis and interpretation of data, statistical analysis, and manuscript preparation. ... during OA by inducing the synthesis of major catabolic and inflammatory mediators via the p38 and p42/44 signalling pathways. Furthermore, PAR-2 upregu...

Ngày tải lên: 09/08/2014, 10:22