Báo cáo y học: " Molecular mechanisms of autoimmunity triggered by microbial infection" potx

... secondary RNA structures as synthetic RNAs, mRNA, and siRNA similarly induce the production of type I IFNs and pro-inflammatory Review Molecular mechanisms of autoimmunity triggered by microbial infection Hans-Joachim ... on those mechanisms that link TLR-induced immunity to mechanisms clearly involved in autoimmunity. TLR ligation and autoimmunity Autoimmunity is obvi...

Ngày tải lên: 09/08/2014, 07:20

... understanding of the molecular virology of HCV infection. The investigation of the HCV life cycle and pathogenesis has been complicated by the lack of efficient cell culture systems and small ... Assistant Professor of Medicine and Staff Physician at the Department of Gastroenterology and Hepatology, University Hospital Freiburg, Germany. Since 2004 he is the head of t...

Ngày tải lên: 02/11/2012, 10:00

... functional studies of the carboxyl-terminal domain Yoko Kobayashi, Toshiaki Nakajima and Ituro Inoue Division of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, Tokyo, Japan Lipoprotein ... Only a trace peak of LPL activity was detected at the same position as the high- affinity peak of wild-type LPL. The LPL in the eluate was detected by Western blot wi...

Ngày tải lên: 21/02/2014, 15:20

... removal of a phosphate, acetyl or methyl group), leading to a product that is distin- guishable by mass spectrometry or immunochemistry from the incoming molecular entity. The modification imposed by ... determined by X-ray crys- tallography [34]. In this structure of the peptide–CDC4 complex, however, Pin1 is missing, whereas in the study on cyclin E degradation, Pin1 was brought...

Ngày tải lên: 07/03/2014, 05:20

... & Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada; 2 Laboratory of Gynecologic Oncology, Department of Obstetric Gynecology and ... (X and Y) . As bands X and Y were only partially inhibited by 500-fold excess of unlabelled wild-type oligo- nucleotide, we propose that the proteins involved in these complexes have very...

Ngày tải lên: 08/03/2014, 23:20

... and dephosphorylation of treha- lose-6-P to trehalose by trehalose-6-P phosphatase (TPS2). Studies based on two-hybrid analyses and on Western blot analyses of complexes obtained by gel filtration ... only with TPS1 and TPS2 [6]. Another component of trehalose metabolism is the hydro- lysis of trehalose to glucose. This is catalyzed by the enzyme neutral trehalase (NTH1), whose a...

Ngày tải lên: 08/03/2014, 23:20

... methods The subunit molecular mass of the enzyme was deter- mined by SDS/PAGE (12.5% polyacrylamide). Protein Fig. 3. Phylogenic tree of plant S-adenosyl- L -methionine-dependent O-methyltransferase sequences. ... tetrahydrocolumbamine using this 80% pure tetrahydrocolumbamine. To quantify the enzymatic activity of CoOMT, the transfer of the 3 H-labeled methyl group of S-adenosy...

Ngày tải lên: 17/03/2014, 10:20

... transcrip- tion by being an auxiliary member of the RNA polymerase II holoenzyme complex. This view is sup- ported by the observation that the function of MRG19 is reminiscent of Gal11p in many respects, ... results clearly show that MRG19 plays a regula- tory role in the expression of genes driven by GAL1 and CYC1 promoters. However, the exact mechanism by which Mrg19p regula...

Ngày tải lên: 31/03/2014, 08:20

... Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O’Garra A: In vitro generation of interleukin 10-producing regulatory CD4 + T cells is induced by immunosuppressive drugs and inhibited by T helper type ... is clearly an inhibitory receptor, there is controversy over whether its ligands PD-L1 and PD-L2 are costimulatory or inhibitory. Differential regulation of PD-L1 and L2 by Th1 and Th2...

Ngày tải lên: 09/08/2014, 01:24

... http://arthritis-research.com/content/4/4/266 capacity of high doses of folinic acid to reverse the thera- peutic effects: first, folinic acid may bypass the effects of methotrexate on reduction of folic acid and thereby bypass the therapeutic ... that inhibits the synthesis of purines and pyrimidines for the therapy of malignancies, it is now clear that many of the anti- inflam...

Ngày tải lên: 09/08/2014, 03:24