Báo cáo y học: "Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis" ppsx

... 6 Research article Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis John R Glossop, ... associated with a protective role in familial RA [30]. In this study we report that polymorphism in the TNF-RII gene, but not the TN...

Ngày tải lên: 09/08/2014, 07:20

... further identify amino acid side chains involved in the docking of cytochrome c, or in the presumed electron entry from cytochrome c to the Cu A center. Positions subjected to mutagenesis in this ... complex of the respiratory chains of mitochondria and many bacteria [1–4]. It catalyzes the reduction of oxygen to water, coupling the free energy of this reaction to...

Ngày tải lên: 22/02/2014, 07:20

... This raises the possibility that any one or a combination of these properties may in uence the binding of apolipoproteins to lipoprotein particles. The capacity to fractionate lipid emulsions into ... [13,16]. ApoE3 is the most common isoform and is associated with normolipide- mia [13,17], while the apoE4 isoform is independently associated with an increased risk...

Ngày tải lên: 08/03/2014, 09:20

... (chronic hyperplastic rhinosinusitis) but without polypo- sis and those patients with diffuse sinonasal polyposis with polyps projecting into or com- pletely occluding the nasal airway (CRS with polyposis). ... impact of this new technology has been, theoretically, to increase the safety and com- pleteness of surgery in addition to increasing the confidence of the surgeo...

Ngày tải lên: 08/08/2014, 20:23

... proteins. It is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the antibody responses, inflam- mation, ... and reproduction in any medium, provided the original work is properly cited. of native C3, res ulting into binding of factor B, which is cleaved by facto...

Ngày tải lên: 08/08/2014, 21:20

... provided new insights into how OA may be successfully managed. The symptoms of osteoarthritis: pain and instability The pain of OA is activity-related, with pain coming on generally only when a person ... the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in...

Ngày tải lên: 09/08/2014, 01:22

... 1 Composite indices are the best depicters of disease activity. The degree of disease activity at the start of a disease-modifying therapy is a major determinant of the disease activity attainable in ... proinflam- matory cytokine interleukin-6 (IL-6) and the observation that CRP levels over time correlate with joint damage [10,21] indirectly link joint damage to th...

Ngày tải lên: 09/08/2014, 01:22

... Calin, of Bath, UK, had started this kind of work in the early 90s with the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [21], the Bath Ankylosing Spondylitis ... probably will be published early in 2009. In these criteria, sacroiliitis detected either by x-rays or by MRI will play a dominant role. The exact diagnostic value of active...

Ngày tải lên: 09/08/2014, 01:22

... cellular localisation. Pyrin is thought to interact with a variety of proteins within the cytoplasm and to play a key role in the modulation of inflammation and apoptosis [11]. Many of its interactions appear ... TNF, tumour necrosis factor; TNFR1, tumour necrosis factor receptor 1; TNFRSF1A, tumour necrosis factor receptor superfamily 1A; TRAPS, tumour...

Ngày tải lên: 09/08/2014, 01:22

... members of the HIF family in the pathogenesis of SSc has not yet been investigated in detail. Insufficient response to hypoxia: dysregulation of angiogenesis in systemic sclerosis Angiogenesis and ... Angiogenesis and vasculogenesis in systemic sclerosis. Rheumatology (Oxford) 2006, 45(suppl 3):iii26-iii27. 52. Varga J, Bashey RI: Regulation of connective tissue synthesis...

Ngày tải lên: 09/08/2014, 01:22