... Martini21Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy2Departments of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, ItalyCorresponding ... (2-p-[2-car-bowyethyl]pheylethylamino)-5'N-ethylcarboxamidoadenosine; CPA = cyclopentyladenosine; Kd = affinity constant; NECA = 5'-N-ethylcarboxami-doadenosine; R-PIA = R-N6-phenylisopropyladenosine; ... stimulation of adenylyl cyclase activity in control (empty circles) and systemic sclerosis (SSc; filled cir-cles) neutrophil membranesA2B adenosine receptor (AR)-mediated stimulation of adenylyl cyclase...