Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps

... RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines (TNF-α, ... progressively failing myocardium) fashion, contributing to subclinical and eventually clinically recognizable ventricular dysfunction (Fig. 1). Inflammatory pathways and myocard...

Ngày tải lên: 09/08/2014, 07:20

... the amount of synovium infiltrating cells, including plasma cells [39]. Because RF-producing cells are present in inflamed rheumatoid synovium and the local environment may favour synovial RF production ... phenomenon, lasting about 1 year. This might explain why almost all of the infliximab-induced lupus syn- dromes were reported within the first year of treatment in RA. No differenc...

Ngày tải lên: 09/08/2014, 01:23

... double-stranded DNA induced in rheumatoid arthritis patients following treatment with inflixi- mab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized ... online http://arthritis-research.com/content/6/6/R535 R535 Vol 6 No 6 Research article Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclea...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... source [37,38]. In addition, Takemura et al. [38] report that endothelial cells lining small arterioles and capillaries, and synovial fibroblasts in the lining and sublin-...

Ngày tải lên: 09/08/2014, 03:24

... DRB1 In the initial, retrospective study, the frequency of B cells was determined as a percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes combined (CD3 + + CD19 + lymphocytes). ... structures and recirculate into the peripheral circulation [20,21]. In the present study, the accessible B lymphocytes in the peripheral circulation were analyzed by flow cytometr...

Ngày tải lên: 09/08/2014, 03:24

... disease activity, and in such cases it is difficult to define repair clearly. Third, there is an interval between clinical findings and corre- sponding radiographic phenomena in clinical trials, and most clinical ... A, et al.: Min- imal clinically important difference in radiological progression of joint damage over 1 year in rheumatoid arthritis: preliminary results of a v...

Ngày tải lên: 09/08/2014, 08:22

... modifications regulating inflammatory processes The transcription factor NF-κB plays a central role in the induction of genes involved in immunity and inflammation, including cytokines, chemokines, adhesion ... primary transcripts within an alternative (mirtronic) pathway by splicing and debranching. Finally, from the resulting miRNA duplex, the strand with the higher affinity is asse...

Ngày tải lên: 09/08/2014, 13:21

... fungus growing in a cavity, in the lung or a sinus, often a maxillary sinus. Aspergilloma has been found in 3.7% of patients under- going surgery for chronic inflammatory sinusitis [12]. Sinus aspergilloma ... sinus imaging was performed [10]. In our study, CT of the sinuses was performed only to investigate symptoms. Sinus aspergilloma may remain asymptomatic for several years, howev...

Ngày tải lên: 09/08/2014, 14:22

... anti-citrullinated protein antibodies), which can be found already in the preclinical phase of the disease; the presence of lymphocyte aggre- gates containing B cells, which are often surrounded by large numbers ... plasma cells, in the inflamed synovium; and experimental studies showing, for instance, the effects of immune complexes containing rheumatoid factor on tumor necrosis fact...

Ngày tải lên: 09/08/2014, 14:22

... MAPK kinases (MKKs), which largely determine the balance of MAPK activation in response to inflammatory stimuli [8,9]. The second interesting observation by Goertz and colleagues is the inability ... N-terminal kinase is required for met- alloproteinase expression and joint destruction in inflamma- tory arthritis. J Clin Invest 2001, 108:73-81. 3. Mengshol JA, Vincenti MP, Coon CI, Ba...

Ngày tải lên: 09/08/2014, 07:20