Báo cáo y học: "Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele" docx

... population comparison group for the athletes. Study instruments To allow a comparison to the group of the general population in Germany, besides the AQUA question- naire [25] (top athletes only), addit ... countryside and it is known that the prevalence of asthma and allergies is lower in these people [26]. Furthermore, it has to be kept in mind that the survey was don...

Ngày tải lên: 08/08/2014, 21:20

... proteoglycan synthesis (Fig. 3). IGF-1 (1.3 nM) alone stimulated total proteoglycan synthesis by a factor of 3.2 (Fig. 3a). The addition of a fourfold molar excess of IGFBP- 3 completely abolished the ... are the main determinants of chondrocyte insensitivity to the action of IGF-1. To further test this hypothesis, we incubated chondrocytes for 24 hours with IGF-1 and then add...

Ngày tải lên: 09/08/2014, 01:23

... http:/ /arthritis- research.com/content/7/6/R1200 R1200 Vol 7 No 6 Research article Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor ... seronegative for rheumatoid factor. Transmission, percentage of heterozygous 1858C/T parents transmitting the 1858T allele. The plan was to test th...

Ngày tải lên: 09/08/2014, 07:20

... appears to be regulated not only by inflammatory cytokines but also by the physical interaction of activated leukocytes with fibroblast-like synoviocytes, and that IP-10 may contribute to the recruitment ... potent angiogenic factor, namely vascular endothelial growth factor, was markedly induced by the interaction of FLS with synovial leukocytes via the integrin/ICAM-1 pathway...

Ngày tải lên: 09/08/2014, 01:21

... increase synovial tissue apoptosis levels in rheumatoid arthritisIntra-articular glucocorticoids do not increase synovial tissue apoptosis levels in rheumatoid arthritis. Frozen sections of rheumatoid ... 4). Soluble factor( s) rather than cellular interaction are essential for the induction of the T-cell apoptosis-resistant phenotype. To further investigate the mechanism re...

Ngày tải lên: 09/08/2014, 01:22

... Fcgamma receptor IIIA genotypes in susceptibility to rheumatoid arthritis. Arthritis Rheum 2000, 43:735-739. 16. Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and ... heterogeneous autoimmune dis- ease that is characterized by chronic inflammatory polyarthritis [1]. One of the characteristic features of RA is the expression of several autoantibod...

Ngày tải lên: 09/08/2014, 07:20

... pregnancy, and yet all three of these medications carry an FDA Pregnancy Category D. These discrepancies are critically important for the rheumatologist and the pregnant patient as the FDA category is ... [94,95]. To date no published information is available on the use of anakinra in pregnancy. Therefore, information is insufficient to evaluate the safety of these medic...

Ngày tải lên: 09/08/2014, 08:22

... RJ: The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987, 30:1205-1213. 3. Weyand CM, Goronzy JJ: ... carrying the risk allele have reduced capacity to produce ROS, which is linked to increased risk for development of arthritis [21,22]. Apart from NCF1, the NOX complex i...

Ngày tải lên: 09/08/2014, 10:21

... propose the use of monocyte-targeted therapies rather than T-cell apoptosis- inducing therapies. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease that is characterized by excessive ... the rheumatoid synovium. The essential factor in this situation appears to be the T cell-monocyte interaction to the extent that T-cell isolation renders the...

Ngày tải lên: 09/08/2014, 13:22

... Sebba A: Tocilizumab monotherapy is superior to methotrexate monotherapy in reducing disease activity in patients with rheumatoid arthritis: the AMBITION study [abstract]. Ann Rheum Dis 2008, ... Maini RN; Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group: Infliximab and methotrexate in the treatment of rheumatoid arthritis. N En...

Ngày tải lên: 09/08/2014, 01:22