Báo cáo y học: " MAPK signalling in rheumatoid joint destruction: can we unravel the puzzle? " pps

... & Therapy October 2005 Vol 7 No 5 Meyer and Pap at the same time they strengthen the concept of p38 and ERK as important MAPKs in the inflamed synovium. In line with previous data, the results ... upstream MAPK kinases (MKKs), which largely determine the balance of MAPK activation in response to inflammatory stimuli [8,9]. The second interesting observation by Goertz...

Ngày tải lên: 09/08/2014, 07:20

... Therapy Vol 10 No 5 Drexler et al. evidence implicating certain signalling pathways in driving the continuous production of pro-inflammatory mediators in the RA joint. The danger signal hypothesis The ... ability to interact with phosphatidylinositol-4,5-bisphosphate [42] (Figure 1). Evidence obtained in murine and human models indicate the involvement of the MyD88-depend...

Ngày tải lên: 09/08/2014, 10:23

... (1:100 in PBS) were dis- tributed into the appropriate wells. The microtitre plates were coated with a highly purified synthetic cyclic peptides containing modified arginine residues. After incubation ... the aCL antibody pro- file has not previously been systematically studied in rela- tion to anti-TNF therapy [37]. We observed a significant increase in aCL antibody titres, sta...

Ngày tải lên: 09/08/2014, 01:23

... complement- dependent cellular cytotoxicity of the cells expressing the cytokine [37]. Furthermore, infliximab has been shown to increase the number of apoptotic T lymphocytes in the lam- ina propria [38] and ... autoimmune endocrine diseases, which have been reported in therapy that interferes with cytokine balance [21]. In the present study we investigate the prevalence...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... synovial T lympho- cytes. The marked expression of the chemokine recep- tors CXCR3, CXCR6 and CCR5 on memory CD4 + T lymphocytes, which represent the predominant infiltrate th...

Ngày tải lên: 09/08/2014, 03:24

... DRB1 In the initial, retrospective study, the frequency of B cells was determined as a percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes combined (CD3 + + CD19 + lymphocytes). ... CD4 + CD45RA + -naive T cells were determined in parallel to the CD19 + B cells using the TRUCOUNT ® technology. In addition, the total lymphocyte and monocyte counts were o...

Ngày tải lên: 09/08/2014, 03:24

... [112,115,116]. In the inflamed synovium of the rheumatoid joint, macrophage-derived cytokines such as TNF-α, IL-1 and IL-6 are prominently expressed, and inhibitors of these cytokines, particularly TNF inhibitors, ... linking inflammation to CHF and the lack of efficacy of anti-cytokine therapy in clinical trials in advanced CHF (discussed below). Because anti-cytokine therapy...

Ngày tải lên: 09/08/2014, 07:20

... simultaneously with repair in other joints in the same patient. In fact, new ero- sions were observed in four patients (30.8%) in the repair observed group. Another interesting finding from our study was ... repairs [45.5%]) were detected in PIP joints. We believe we can partially explain this by the fact that more erosions were observed at PIP joints than at other bon...

Ngày tải lên: 09/08/2014, 08:22

... their synthesis is the methylation of nucleotides. This modification changes the function of the methylated DNA dramatically. In eukaryotes, methylation is restricted to the pyrimidin base cytosine, ... activity of LINE-1 was associated with genomic hypomethylation in RASFs. In accordance, very recent data strongly support the hypothesis that genomic hypomethylation might play...

Ngày tải lên: 09/08/2014, 13:21

... sinus imaging was performed [10]. In our study, CT of the sinuses was performed only to investigate symptoms. Sinus aspergilloma may remain asymptomatic for several years, however, and may therefore be ... methotrexate in one case). Little information was available about the treatments in the ankylosing spondylitis patients; however, two of these patients received radiation therap...

Ngày tải lên: 09/08/2014, 14:22