Báo cáo y học: "Somatic mutations in mitochondria: the chicken or the egg" docx

... osteoarthritis (OA). More importantly, in RA tissue significantly more of these mutations resulted in non-synonymous amino acid changes than those in tissues of patients with OA. Mutations in mtDNA have ... mtDNA mutations actually provoke pathological states or should they be considered epiphenomena? In other words, why do somatic mtDNA mutations increase, and what conseq...

Ngày tải lên: 09/08/2014, 07:20

... University Health Network, Toronto, Ontario, Canada 3 Department of Medicine, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada Corresponding author: Tanya R Da Sylva, dasylva@yorku.ca Received: ... in RA. Competing interests The author(s) declare that they have no competing interests. Authors' contributions TD participated in the design of the study, perfor...

Ngày tải lên: 09/08/2014, 06:23

... currently the first line of therapy in early inflammatory disease; however, with the availability of more effective (but more expensive) agents, are we justified in now using these at the onset ... combination group, but by only 25% in the monotherapy groups. The results of these studies show that TNF-blocking drugs, used either in combination or as monotherapy, have a mor...

Ngày tải lên: 09/08/2014, 10:20

... fungus growing in a cavity, in the lung or a sinus, often a maxillary sinus. Aspergilloma has been found in 3.7% of patients under- going surgery for chronic inflammatory sinusitis [12]. Sinus aspergilloma ... imaging was performed [10]. In our study, CT of the sinuses was performed only to investigate symptoms. Sinus aspergilloma may remain asymptomatic for several years, howev...

Ngày tải lên: 09/08/2014, 14:22

... with the highest mapping quality retained. Further, erroneous mapping of reads originat- ing from D NA present in sequence gaps in NCBI build m37 assembly were removed by excluding the highly repetitive ... We sequenced the remaining Trp53 allele in these tumors butwereunabletoidentifyanysomaticmutations resulting in a loss of heterozygosity. The features of the Varela et al...

Ngày tải lên: 09/08/2014, 22:23

... be included in the risk assessment regarding possible major incidents in this region. The purpose of this study was to find whether this institution has achieved its primary tasks by analyzing ... a senior surgeon or anesthesiolo- gist with training in disaster medicine) was created. In this 24/7 system, the RTiB is the POC for the healthcare facili- ties within the regi...

Ngày tải lên: 25/10/2012, 09:56

... factors for DM. Neither treatment-emergent weight gain nor treatment group significantly impacted the risk for TED. Established risk factors for diabetes include: family history, ethnicity, increasing ... Angiotensin Converting Enzyme CYP = Cytochrome P450 + Not all agents are appropriate for monotherapy. Inclusion in this table does not necessarily imply efficacy. * Currently FDA approv...

Ngày tải lên: 25/10/2012, 10:51

... using temporal fascia is similar to the one introduced by Yu et al. 32 They separated the temporal deep fascia from the temporal muscle to the zygomatic arch, and then cut the fascia from the ... along th e zygoma but left the fascia base 1-2 cm long for the blood supply. Finally, they turned the temporal fascia beneath the temporal muscle and sutured it to the...

Ngày tải lên: 25/10/2012, 11:40

... quickly and efficiently, and increasing mortality, high economic burden for removal of in- fected joint prosthesis and implant renewing [17] al- ways require the increased effort in sampling and ... by examination of typical laboratory medicine and mi- crobiology characteristics in joint fluid. In addition to the macroscopic parameters (e.g. color, viscosity) the gram stain i...

Ngày tải lên: 26/10/2012, 09:57

... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations ... results. The Lys751Gln polymorphism has been more studied than the Asp312Asn polymorphism, because the frequency of the 751Gln allele is more prevalent than the 312A...

Ngày tải lên: 31/10/2012, 14:59