Báo cáo y học: "Rheumatoid arthritis as a hyper-endoplasmic reticulumassociated degradation disease" pdf

... ERAD system eliminates unfolded proteins that Commentary Rheumatoid arthritis as a hyper-endoplasmic reticulum- associated degradation disease Satoshi Yamasaki 1 , Naoko Yagishita 1 , Kaneyuki ... OA synovial cells (n = 5) (Yamasaki S, Yagishita N, Tsuchimochi K, Kato Y, Sasaki T, Amano T, Beppu M, Nakamura H, Nishioka K, Nakajima T, unpublished data). These results suggest that RA...

Ngày tải lên: 09/08/2014, 07:20

... the patients' charts. The diagno- sis for RA was based on a rheumatologist's evaluation. Coronary angiogram data Angiographic data was retrieved from the Mayo Clinic coro- nary care ... coronary artery bypass graft; CAD = coronary artery disease; CV = cardiovascular; HR, hazard ratio; DMARD = disease-modifying antirheumatic drugs; MI = myocardial infarction; OR = odds ratio; PTCR...

Ngày tải lên: 09/08/2014, 06:23

... concentration was determined spectro- photometrically [24]. PK activity was evaluated as a cell-age marker by the method of Beutler et al.[16]. Statistical analysis Statistical analysis was performed ... proteins, catalysed by PCMT, is increased as erythrocytes age in the circulation [6,25,26]. This has been related to an increased number of abnormal aspartate residues, spontaneously ar...

Ngày tải lên: 08/03/2014, 22:20

... drug-resistant human B cell lymphomas to the cytotoxic effect of CDDP, VP1- and toxins [abstract]. FASEB J 1995, 9 :A2 06. 8. Kosmas C, Stamatopoulos K, Stavroyianni N, Tsavaris N, Papadaki T: Anti-CD20-based ... in the treatment of a variety of autoimmune syndromes, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and vasculitic syndromes. Plasmapheresis still has...

Ngày tải lên: 09/08/2014, 01:21

... on small nuclear ribonucleopro- teins that react with human autoantibodies as well as with Arthritis Research & Therapy Vol 6 No 2 Vossenaar et al. R148 Arthritis Research & Therapy Vol ... early rheumatoid arthritis. Arthritis Rheum 2002, 46:1196-1201. 36. Menard HA, El-Amine M: The calpain-calpastatin system in rheumatoid arthritis. Immunol Today 1996, 17:545-547. 37. Es...

Ngày tải lên: 09/08/2014, 01:23

... had psoriatic arthritis for 8 years, and one patient who had had ankylosing spondylitis for 30 years. Each patient with spondyloarthropathy was taking sulfasalazine. No patient in the study was ... (f–h). Data are means of duplicate samples and are from two separate SF donors. Arthritis Research & Therapy Vol 7 No 2 Cavanagh et al. R231 The synovial autoimmune reaction of rheumatoid...

Ngày tải lên: 09/08/2014, 06:22

... Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, et al.: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine ... linkage analysis of rheumatoid arthritis, including covariates. Arthritis Rheum 2004, 50:2757-2765. 2. Shiozawa S, Hayashi S, Tsukamoto Y, Goko H, Kawasaki H, Wada T, Shimizu K, Yasuda N,...

Ngày tải lên: 09/08/2014, 07:20

... exposed at the site of overwhelming injury may act as a sink to exhaust the supply of plasma gelsolin, in turn allowing redundant inflammatory cascades unfettered opportunity to wreak havoc upon multiple ... the sequestration hypothesis, as long as the isoform associated with the complexes is plasma gelsolin. Rheumatoid arthritis represents a chronic inflammatory state punctuated...

Ngày tải lên: 09/08/2014, 13:22

... antigens of antifilaggrin autoantibod- ies are deiminated forms of fibrin alpha and beta chains [abstract]. Rev Rheum 1999, 66:754. 33. Nakayama-Hamada M, Suzuki A, Furukawa H, Yamada R, Yamamoto ... (especially ≥25 pack years) was significantly associated with RF positivity, radiographic erosions and nodules [54]. In another study there was a correlation between heavy smoking (≥20 pack-ye...

Ngày tải lên: 09/08/2014, 14:22

... were available, to examine the relation- ship between uTWEAK levels and disease activity over time. Classification of systemic lupus erythematosus activity status LN activity was evaluated based ... temperature. Finally, the plates were washed and a developer solution was added. TWEAK levels were derived from an average of the duplicate assays that were carried out for all samples. All ass...

Ngày tải lên: 09/08/2014, 14:22