Báo cáo y học: "Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis" pptx

... regulators of immunity display an extraordinary capacity to induce T cell responses and secrete a variety of cytokines; the differentiation status of DCs can influence whether its target lymphocyte–often ... being involved in one study [71] but not in another study [72]. This discrepancy may be due to the subtle phenotypic variations induced in BMMSCs by the many methods available...

Ngày tải lên: 10/08/2014, 05:21

... activated, probably as a result of inflammation in RA ST. Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (Pyk)2 are two members of a family of nonreceptor protein tyrosine kinases that ... by a variety of extracellular stimuli [1]. FAK and Pyk2 associate with the cytoskeleton and with integrin-signaling complexes by binding to Src kinase and paxillin [2-5]. FAK is rapi...

Ngày tải lên: 09/08/2014, 10:21

... min. The supernatant was adjusted to 3% poly(ethylene glycol) 4000 by adding 0.11 vol. of a 30% poly(ethylene g lycol) solution in buffer A . After 5 min, precipitated protein was removed by ... discrepancy, the 6PF2K activity of the recombinant enzyme is inhibited by the s ame range of three-carbon phosphorylated intermedi- ates as that of the enzyme from spinach leaves [8,10,11]....

Ngày tải lên: 22/02/2014, 04:20

... in Fig. 4, dimerization of RIIa D/D is main- tained by strong hydrophobic interactions of side chains that form the core of the protein at the dimer interface. The formation of a clustering of ... by A-Kinase Anchoring Proteins (AKAPs). The site of interaction with AKAPs is the N-terminal docking and dimerization (D/D) domain of the regulatory (R) subunit of PKA. While early...

Ngày tải lên: 08/03/2014, 22:20

... bonds in the C-terminal subdomain, Cys233– Cys433 and Cys292–Cys457, fasten the C-terminal peptide to the main body of the catalytic unit (Fig. 6). Both disulfide bonds as well as the C-terminal ... specificity of PB2-T1 and PB2-T2 toward intact protein substrates, some commercially available proteins, which include human serum albumin, cytochrome C, lysozyme, alcohol dehy- drogenase, b-a...

Ngày tải lên: 17/03/2014, 10:20

... was to bring together workers in the fields of MSC biology and AD in order to define areas of potential synergy and interdisciplinary collaboration. As pointed out by the director of the institute, ... of STAT5 Murine in vitro [76] (2006) phosphorylation in lymphocytes DC, dendritic cell; HGF, hepatocyte growth factor; IDO, indoleamine 2′,3′-dioxygenase; IL, interleukin; MLR,...

Ngày tải lên: 09/08/2014, 08:23

... Toshiya Sato, PhD, Professor of Biostatistics, Graduate School of Medicine, Kyoto University, for advising on the statistical analysis. References 1. Toyras J, Lyyra-Laitinen T, Niinimaki M, Lindgren ... of Medicine, Kyoto University, 54 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto 606-8507, Japan 3 Department of Applied Medical Engineering Science, Graduate School of Medicine, Yamaguchi...

Ngày tải lên: 09/08/2014, 10:23

... M, Papa N, Cinquini M, Magrini L, Tin- cani A, Valesini G: Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid ... study, up to 25% of per- sons more than 85 years old were IgM-RF-positive [10]. In a similar study, ACPA positivity was observed in only 1 out of 300 healthy individuals over 75 year...

Ngày tải lên: 09/08/2014, 14:21

... change that results in bypassing a proofreading mechanism of the Sec machinery [25]. The energy for precursor translocation is supplied by the hydrolysis of ATP by SecA and by the proton-motive ... mutation in secY reduced the pmf dependency of protein translocation [21]. Similarly, a single amino-acid substitution, replacing the helix-breaking glycine at position )10 in the hydro...

Ngày tải lên: 08/03/2014, 09:20

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, a twofold and fourfold increased V s /V h ratiocomparedtothe wild-type (Table 4). The V s /V h r...

Ngày tải lên: 17/03/2014, 23:20