Báo cáo y học: "Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen" ppt

... MA, Seyer JM: Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen. ... antibody response to defined epitopes on CII. Interest- ingly, the antibodies directed against distinct epitopes on the triple-helical part of CII correl...

Ngày tải lên: 09/08/2014, 07:20

... The goal of the present study was therefore the analysis of frequencies and distributions of B-lymphocyte subpopulations, and the comparison of patients positive and negative for RA -associated ... patients. This is contradicted, however, by the lack of association of diminished B-cell numbers with prolonged disease duration or with increased DMARD therapy, or a more rapid...

Ngày tải lên: 09/08/2014, 03:24

... subcutaneous or visceral peripheral nerves, which are usually associated with neurofibromatosis type 1. They are almost always congenital lesions and often cause the surrounding soft tissue and bone to ... significant of this phenomenon. Historically, PE was repaired with chondrosternal resection, or some combination of cartilage incision and osteotomy with or without external o...

Ngày tải lên: 10/08/2014, 09:22

... of 189 patients consisted of 106 cases of colon cancers and 83 cases of rectal cancers with TNM stages varying from I to VI, that is, one group of patients with a definite stage con- tained only ... postoperatively adjuvant chemotherapy for six months. Patients were observed on an every-three-month basis during the first year, once every 6 months in the second year, and by te...

Ngày tải lên: 18/06/2014, 15:20

... the treatment of NPC with increasing interest in cyclooxygen- ase-2 (COX-2) inhibitors. COX-2 is a 68 kDA enzyme that catalyses the conversion of arachidonic acid to prostaglandins. Over-expression of COX-2 ... chemoradiotherapy followed by adjuvant chemother- apy in patients with American Joint Committee on Cancer/ International Union against cancer stage III and IV nasopha-...

Ngày tải lên: 09/08/2014, 10:20

... polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease. Arthritis Res ... autoantibody Table 2 Frequency distribution of the 1858 C/T polymorphism of PTPN22 in patients with early rheumatoid arthritis and matched controls Genotype Patients (n = 504) Cont...

Ngày tải lên: 09/08/2014, 10:20

... number of heterozygote parents. Table 3 Genotype relative risk analysis for single nucleotide polymorphism (SNP)1 and SNP2 in sample 1 of rheumatoid arthritis trio families Genotype Rheumatoid arthritis ... M, Gougerot-Pocidalo MA, Gaudry M: Suppression of arthritis and protection from bone destruction by treatment with TNP-470/ AGM-1470 in a transgenic mouse model of rheumat...

Ngày tải lên: 09/08/2014, 10:20

... number of study participants, and measurement of CRP by a highly sen- sitive assay. A potential limitation of this study is that hsCRP was only measured on one occasion. Although serial sampling of ... assessed by a longitudinal study. Introduction Osteoarthritis (OA) is a major cause of morbidity, affecting 60% of men and 70% of women over the age of 65 years [1]. In pa...

Ngày tải lên: 09/08/2014, 10:23

... accelerated development of joint inflammation in the collagen-immunized arthritis (CIA) model compared with wild -type mice [13]. The severity of arthritis and the circulating levels of anti -type II col- lagen ... identify loss of flexion (ankylosis). Joints received an additional score of 3 for the presence of distortion and 3 for the presence of ankylosis (maximum...

Ngày tải lên: 09/08/2014, 06:23

... system, coupled with dy sfunctional T cells or enhanced cytokine responses, may be associated with the develop- ment of symptomatic malignancy. Our study had several limitations. The analysis ... a dysregulation of pathogen-speci- fic imm une responses, commonly referred to as immune reconstitution inflammatory syndrome (IRIS) [18,19]. B-cell NHL as a manifestation of IRIS is po...

Ngày tải lên: 10/08/2014, 05:21