Báo cáo y học: "Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo" doc

... online http://arthritis-research.com/content/7/5/R1140 R1140 Vol 7 No 5 Research article Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane ... by proinflammatory cytokines, which not only induce but also maintain synovitis and therefore play an important role in pro- gressive joint destruction [1,2]. Se...

Ngày tải lên: 09/08/2014, 07:20

... increase in Cyp7b activity We further investigated a putative role for MAPKs in the TNF- α-induced increase in Cyp7b activity by using the MEK1 inhib- itor PD98059 and the p38 inhibitor SB203580. The ... protein kinase (ERK) 1/2; the stress-activated protein kinases, also called c- Jun NH 2 -terminal kinases (JNKs); and the p38 MAPKs [13]. The JNK pathway is o...

Ngày tải lên: 09/08/2014, 07:20

... were small and non-significant. Serum osteocalcin rose and the resorption marker urinary deoxypyrdinoline decreased. Most of these reports have been with infliximab. It is unclear whether a similar ... automated radiogrammetry. Moreoever, automated radiogrammetry using hand X-rays shows a strong correlation with BMD assessed by dual energy X-ray absorptiometry [13]. In summary, studie...

Ngày tải lên: 09/08/2014, 10:20

... reduced TIARP mRNA in splenocytes. In arthritic mice, TIARP mRNA was expressed mainly in CD11b + cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied by joint swelling), especially ... receptor (tumor necrosis factor receptor superfamily)-interacting serine-threonine kinase 1 and 2; TNFAIP, tumor necrosis factor alpha-induced protein;...

Ngày tải lên: 09/08/2014, 14:22

... Obesity-induced insulin resistance is thereby characterized by a loss of insulin sensitivity mediated by factors released from adipocytes, mainly free fatty acids and proteins, termed adipocytokines, ... elevated in obesity-associated insulin resistance and diabetes, inhibit insulin signalling at several points in the signalling cascade. The liver is critical in maintaining cir-...

Ngày tải lên: 16/03/2014, 02:20

... TNF-α promotes further expression of cytokines and chemokines by synovial cells and chondro- cytes, thereby sustaining a renewal of local inflammatory mediators (reviewed in [9,10]). The presence ... = interleukin; MAPK = mitogen-activated protein kinase; MEK1/2 = mitogen-activated protein kinase kinase 1 and 2; NF = nuclear factor; PARP = poly(ADP ribose) polymerase; PKC...

Ngày tải lên: 09/08/2014, 06:22

... hypervascularity typical of SpA and a reduction of the synovial lining hyperplasia, indicating that infliximab also modulates the structural synovial charac- teristics of the disease. In another study [12], ... Kennedy L, Garrett S, Calin A: Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS metrology index. J Rheumatol 1994, 21:1694-1698. 6. Van den Bosch...

Ngày tải lên: 09/08/2014, 06:23

... was involved in the design of the study, performed all the experiments and wrote the manuscript. PB was involved in performing cell cultures, flow cytometry and gel shift assays, and reviewed the ... design of the study and reviewed the article critically. AC was involved in the conception and design of this study, in the interpretation of data and review...

Ngày tải lên: 09/08/2014, 10:20

... Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. ... was involved in the conception and design of the study, analysis and interpretation of the data, and did most of the drafting of the manuscript. All authors...

Ngày tải lên: 09/08/2014, 14:22

... abolished the DNA -protein binding activity induced by HBO. Exogenous addition of TNF-a significantly increased the DNA -protein binding activity. To study whether the visfatin expression induced by HBO ... 18:27 http://www.jbiomedsci.com/content/18/1/27 Page 4 of 14 HBO increased AP-1 binding activity. TNF-a antibody and SP600125 inhibited the AP-1 binding activity induced by HBO...

Ngày tải lên: 10/08/2014, 05:21