Báo cáo y học: "Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo" doc

... online http://arthritis-research.com/content/7/5/R1140R1140Vol 7 No 5Research articleTumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane ... byproinflammatory cytokines, which not only induce but alsomaintain synovitis and therefore play an important role in pro-gressive joint destruction [1,2]. Several cytokines are currentlyconsidered ... key signalling pathways in the synovial membrane, such as the MAPKs, and thereby reducesinflammatory response in the tissue exposed to TNF. Reduc-tion in MAPK activation on cytokine blockade...

Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

... increase in Cyp7b activityWe further investigated a putative role for MAPKs in the TNF-α-induced increase in Cyp7b activity by using the MEK1 inhib-itor PD98059 and the p38 inhibitor SB203580. The ... protein kinase (ERK) 1/2; the stress-activated protein kinases, also called c-Jun NH2-terminal kinases (JNKs); and the p38 MAPKs [13]. The JNK pathway is of interest because of its capacity ... 7α-OH-DHEA. In addition, intra-articular delivery of 7α-OH-DHEA and/ or Cyp7b expressionsystems should add to our understanding of the role played byCyp7b in the arthritic process. The inhibitory effect...

Báo cáo y học: "Tumour necrosis factor blockade and the risk of osteoporosis: back to the future " ppt

... were small and non-significant. Serum osteocalcin rose and the resorption marker urinary deoxypyrdinoline decreased.Most of these reports have been with infliximab. It is unclearwhether a similar ... automatedradiogrammetry. Moreoever, automated radiogrammetry usinghand X-rays shows a strong correlation with BMD assessedby dual energy X-ray absorptiometry [13]. In summary, studies like that by Marotte and ... blockers in RA have includedhand X-rays to assess efficacy. Application of such auto-mated radiogrammetry to the existing clinical trial data (suchas these hand X-rays) offers an opportunity to...

Báo cáo y học: "Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis" pptx

... reducedTIARP mRNA in splenocytes. In arthritic mice, TIARP mRNAwas expressed mainly in CD11b+ cells in the spleen, and TIARP mRNA level was increased in the joints (accompaniedby joint swelling), especially ... receptor (tumor necrosis factor receptor superfamily)-interacting serine-threonine kinase 1 and 2; TNFAIP, tumor necrosis factor alpha-induced protein; TNFR, tumor necrosis factor receptor; ... peaked in severity on day 14, and then gradually subsided. High expression levels of TIARP mRNA and proteins were detected in splenocytes on day 7 (the onset of arthritis). In joints, the expression...

Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx

... Obesity-inducedinsulin resistance is thereby characterized by a loss ofinsulin sensitivity mediated by factors released fromadipocytes, mainly free fatty acids and proteins,termed adipocytokines, ... elevated in obesity-associated insulin resistance and diabetes, inhibit insulin signalling atseveral points in the signalling cascade. The liver is critical in maintaining cir-culating glucose ... and, in a preliminary investigation using the humanhepatoma (HepG2) cell line in this study, we demonstrated the role of TNFa in the regulation of this phenomenon and determined the underlyingmolecular...

Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx

... TNF-α promotes further expression ofcytokines and chemokines by synovial cells and chondro-cytes, thereby sustaining a renewal of local inflammatorymediators (reviewed in [9,10]). The presence ... = interleukin; MAPK = mitogen-activated protein kinase; MEK1/2 = mitogen-activated protein kinase kinase 1 and 2; NF = nuclear factor; PARP = poly(ADP ribose) polymerase; PKC = protein kinase ... collagen genes and in remodeling of the cytoskeleton in response to factorspresent during inflammation. The MAPK /ERK pathway plays an important role in direct-ing alterations of the cytoskeleton....

Báo cáo y học: "α Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification" pps

... hypervascularity typical of SpA and areduction of the synovial lining hyperplasia, indicating thatinfliximab also modulates the structural synovial charac-teristics of the disease. In another study [12], ... Kennedy L, Garrett S, CalinA: Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS metrology index. J Rheumatol 1994, 21:1694-1698.6. Van den Bosch F, Kruithof E, Baeten D, De Keyser ... Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P,Jenkinson T: A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath AnkylosingSpondylitis...

Báo cáo y học: "Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes" ppt

... was involved in the design of the study, performed all the experiments and wrote the manuscript. PB was involved in performing cell cultures, flow cytometry and gel shift assays, and reviewed the ... design of the study and reviewed the article critically. AC was involved in the conception and designof this study, in the interpretation of data and reviewed this arti-cle critically. BP and ArC ... E-selectin and intercellular adhesionmolecule, necessary for the flow of leucocytes into the sub-endothelial tissue [6]. It also promotes production of otherproinflammatory cytokines and chemokines,...

Báo cáo y học: "Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro" pptx

... Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. ... was involved in the conception and design of the study, analysis and interpretation of the data, and did most of the drafting of the manuscript. All authors read and approved the final manuscript.AcknowledgementsWe ... 1b). The NO-synthetase inhibitor L-NMMAreduced the basal NO production of the tissue significantly and prevented the TNFα-mediated increase in NO completely.Influence of NO synthetase inhibition...

Báo cáo y học: "Tumor necrosis factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells" ppt

... abolished the DNA -protein binding activity induced by HBO. Exogenous addition ofTNF-a significantly increased the DNA -protein bindingactivity. To study whether the visfatin expressioninduced by HBO ... 18:27http://www.jbiomedsci.com/content/18/1/27Page 4 of 14HBO increased AP-1 binding activity. TNF-a antibody and SP600125 inhibited the AP-1 binding activity inducedby HBO, indicating that TNF-a and JNK pathway mediate the increased transcriptional ... HBO-induced visfatinproteinexpressioninhuman CAECs. Thirdly, JNK kinase and AP-1 transcrip-tion factor are involved in the signaling pathways of visfa-tin induction by HBO. Fourthly, HBO increases...

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