Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt

... correlate with synovial lining cell hyperplasia. A study by Bohm and co-workers [12] described the expres- sion of ADAM15 in RA and OA synovial tissues by immunohis- tochemistry and in situ hybridization, ... hematoxylin and eosin were analyzed by light microscopy according to our grading system of syno- vial lining cell hyperplasia, cellular infiltration and fibrosi...

Ngày tải lên: 09/08/2014, 07:20

... glucose-lowering effect in diabetic mice and may be a promising agent that can treat type 2 daibetes by improving both insulin resistance and insulin secretion deficiency. However, we only ob- served ... the N-terminus of globular adiponectin and the C- terminus of GLP-1-A through the linker, which could make the N-terminus of GLP-1-A and the C-terminus of gAdiponectin...

Ngày tải lên: 25/10/2012, 11:10

... disorders. Many inflammatory factors known to be related with cancer initiation, progression, and invasion are also expressed by OLP-related chronic inflammatory infiltrate, and thus may contribute ... epithelial layers of reticular subtype of oral lichen planus patient (streptavidin-biotin amplified system, x 400). Figure 2. Increased labelling of hMSH2 protein in basal...

Ngày tải lên: 03/11/2012, 09:54

... isoforms of the subunit a of mouse enzyme [22,23], four isoforms of the proteolipid subunit in Caenorhabditis elegans [24] and two isoforms of the subunit A in human osteoclastoma [25]. Isoforms ... these isoforms and the combination of the isoforms is yet to be determined. We are now trying to express fusion proteins of A. acetabulum proteolipid subunits and green fluore...

Ngày tải lên: 08/03/2014, 23:20

... Kuhne, Pierre Flandin, Jean-Paul Giacobino and Patrick Muzzin Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, Switzerland Uncoupling protein-3 (UCP3) is a mitochondrial inner- membrane ... not necessarily result in similar changes at the protein level and indicate that UCP3 density in SS and IMF mitochondria can be differently affected by metabol...

Ngày tải lên: 24/03/2014, 04:21

... synthetase (ASS). In the liver, the AGC plays an important role in the urea cycle by providing aspartate for incorporation into argininosuccinate [17]. The mutations in the citrin gene in patients affected by ... citrin is the only AGC isoform present. This explains why citrin deficiency in humans (type II citrullinemia) only affects the liver and suggests that aralar1 may com...

Ngày tải lên: 24/03/2014, 04:21

... secretion of insulin. Bearing this in mind, we determined the activities of citrate synthase (an enzyme of the Krebs cycle re¯ecting the number of mitochondria [10]), succi- nate dehydrogenase and cytochrome ... After 2 h of incubation, the islets were removed by centrifugation at 280 g for 5 min, and the supernatants obtained were frozen at )80 °C until the insulin assays...

Ngày tải lên: 31/03/2014, 15:20

... studied. Reduction of adiposity by respiratory uncoupling in adipocytes may be limited by mitochondrial oxidative capacity. Importantly, it has been sho wn in vitro [42] that the uncoupling, induced by ectopic ... development of obesity by both, increasing energy expenditure and d ecreasing in situ lipogenesis. In order to further analyse consequences of respiratory un...

Ngày tải lên: 31/03/2014, 15:20

... types, when activated, appear to play a central role in promoting and maintaining the dis- ease process [4,5], for example by producing certain sets of cytokines that influence the quality and ... samples of knee-joint SM, inguinal LNs, and spleen were obtained from rats killed at six time points: day 0, 6 hours, day 1, day 3, and day 6 of AIA. Cytokine protein analysis wa...

Ngày tải lên: 09/08/2014, 06:22

... in the lining layer and the sub- lining layer of RA synovium (Fig. 3). MMP secretion in co-culture of human monocytes/THP- 1 cells and fibroblasts The gel zymography results show that MMP-9 and ... anky- losing spondylitis (AS CD147) and osteoarthritis (OA CD147) syn- ovium. CD147 was predominantly expressed by macrophage-like cells and fibroblast-like synovial cells in...

Ngày tải lên: 09/08/2014, 06:23