Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx

... on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases Jean-Pierre ... extent. Cathepsin K gene expression and protein synthesis The levels of both the gene expression and the prot...

Ngày tải lên: 09/08/2014, 06:23

... design of the study and performed the statistical analysis. ET and KDGD participated in the collection of the blood samples and conception of the study. RC and CB participated in its design and ... elucidate the role of CCR5 gene and of its variants in HIV-1 infection resistance. To the best of our knowledge, the present is the first study investi...

Ngày tải lên: 10/08/2014, 05:20

... presence of medical menis- cal extrusion between control individuals without a family his- tory of OA (6%) and offspring with a family history of OA (9%; P = 0.28). Over 2 years, meniscal extrusion ... age and family history of OA were not associated with medial meniscal extrusion, our definition of past knee injury and weight (body weight, BMI and obesity) were signifi-...

Ngày tải lên: 09/08/2014, 10:20

... 9:32 http://www.annals-general-psychiatry.com/content/9/1/32 Page 4 of 12 28. Dunkel CS, Sefcek JA: Eriksonian lifespan theory and life history theory: an integration using the example of identity formation. Rev Gen Psychol 2009, ... describe the entire lifespan of PTSD distribu- tion. The inclusion of participant s beyond the age of 80 would touch on something new and...

Ngày tải lên: 09/08/2014, 01:21

... Martin B. Rook 2 and Johan W. M. Heemskerk 1 1 Departments of Biochemistry and Human Biology, University of Maastricht, the Netherlands; 2 Department of Medical Physiology, University Medical Centre ... probability of the receptor channels are the luminal Ca 2+ concentration in the endoplasmic reticulum [9,10], modulation or oxidation of the receptor sulfhydryl groups...

Ngày tải lên: 17/03/2014, 17:20

... usually otherwise healthy patients with pure food restriction, normal serum albumin levels frequently mask the severity of their serious m edical condition [6,7]. A recent analysis of patients with ... USA. Authors’ contributions MAF, JLG, PFS and PSM designed the study. MAF performed the sample analysis and the statistical evaluation. JLG consented the patients and re...

Ngày tải lên: 09/08/2014, 01:21

... contributions CLM participated in the design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript. AJF participated in the design of the study and interpretation ... intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration Christine Lyn Le Maitre, Anthony John Freemont and Ju...

Ngày tải lên: 09/08/2014, 10:20

... including chronic inflammation, involvement of peripheral joints, polysyn- ovitis and secondary destruction of cartilage and bone [2]. Its relevance to the pathogenesis of RA is further supported by the ... rarely in patients with RA [20]. In contrast, several studies have demonstrated the ability of PPAR agonists to decrease the severity of experimental polyar...

Ngày tải lên: 09/08/2014, 10:22

... Study design, interpretation of data, revision and final approval of manuscript. ASA: Conception and study design, data acquisition, analysis and interpretation of data, drafting and revision of ... It is possible that the effect of statins on AF is dependent upon the duration of statin-therapy. Conclusion In conclusion, in this large cohort of cardiac surger...

Ngày tải lên: 10/08/2014, 10:20

... changes and neovascularization at the base of the vegetation. The vegetation consists of fibrin-platelet thrombi and shows signs of acute and chronic inflammation with neutrophil and mononuclear ... fibrosis and scarring, ultimately worsening valvular damage and dysfunction [5,33-35]. Nonetheless, appropriate steroid therapy to control SLE disease activ- ity is imp...

Ngày tải lên: 10/08/2014, 10:20