Báo cáo y học: "DAS28 best reflects the physician''''''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx
Báo cáo y học: "DAS28 best reflects the physician''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx
... give a dose increase of infliximab could happen only at one time point. This difference in study design and therapy may explain why in the present study the AUC of DAS28 is smaller than in other studies ... coefficients of this discriminant function were quite similar to the coefficients of the DAS28, indicating the robustness of the scores and coefficient...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... with response to therapy in baseline PBMC samples. They confirmed the asso- ciation of 20 of these transcripts with response to therapy in an additional set of 20 patients [27]. It is striking, ... associ- ated with poor clinical response to therapy, thereby providing clinicians with potential tools to identify these patients prior to initiation of ada...
Ngày tải lên: 09/08/2014, 14:20
Báo cáo y học: "Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis" pot
... tool increasingly used by clinicians, including rheumatologists, but the US data on small joints in PsA are very limited [8,9]; in particular, the validation of the findings is minimal. The aim of the ... purposes) Ratingen scoring system [11] by an experienced musculoskel- etal radiologist (AV) blinded to clinical and other imaging findings. Clinical examination All...
Ngày tải lên: 09/08/2014, 10:21
Báo cáo y học: " Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells" docx
... assay, flow cytometry analysis, and immunoblot analysis. Blockade of TLR3 signaling was achieved using TLR3 neutralizing antibody, small interference RNA, and 2-aminopurine (2-AP), an inhibitor of ... Ganglioneuroblastoma; (IRF3): Interferon regulatory factor 3; (NB): Neuroblastoma; (PKR): Double-stranded RNA-dependent protein kinase; (poly(I:C): Polyinosinic-p olycytidylic acid); (TLR):...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: " Preliminary data concerning the reliability and psychometric properties of the Greek translation of the 20-item Subjective Well-Being Under Neuroleptic Treatment Scale (SWN-20)" pdf
... in order to assess the well-being of patients receiving antipsychotic medication independent of the improvement in their psychotic symptoms. The current study reports on the reliability and the ... designed the study and participated in the analysis of the data, interpretation and writing of the manuscript MS, KM, EP, SM, IC, KA, AC and SD participated in...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: "Mechanical ventilation and the total artificial heart: optimal ventilator trigger to avoid post-operative autocycling - a case series and literature review" pdf
... 10 patients developed autocycling of the ventilator, but autocycling ceased immediately in all of these patients when their ventilator settings were changed from a flow trigger of 2 L/minute to ... ventilator setting. Mechanical ventilator PEEP maintenance maintains pressure at the expense of altered flow, ultimately leading to autocycling in the case of a flow tri...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"
... determined by evaluating the median results of the groups and deciding among the investigators clinical importance. From the data, clinically relevant cut-offs determined by the investi- gators ... at the beginning and at the end of therapy. The Knodell scoring sys- tem for liver biopsy (obtained at baseline) result was used as the indicator of histologic activ...
Ngày tải lên: 26/10/2012, 09:39
Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx
... this understanding is gained, H-tunneling can then be used as a tool for (a) increasing the catalytic efficiency of enzymes in the biotechnology industry (by enhancing the coupling of dynamics to the ... by tunneling in quinoprotein and flavoprotein enzymes that catalyse the oxidation of a number of amine substrates, and computational studies of enzymic H-tunneling in...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo khoa học: "First observations on the root morphology and symbioses of 21 major tree species in the primary tropical rain forest of French Guyana" pps
... ecto- mycorrhizal symbioses seem to be less fre- quent in Venezuela and the Guyanas than in other tropical rain forests, in spite of the fact that the soil fertility is ... in French Guyana, no local factor is responsible for the rarity of ectomycor- rhizas. Introduced pines and eucalyps in nearby plantations were massively ecto- myco...
Ngày tải lên: 08/08/2014, 19:21
Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt
... levels of RAGE expression, which is induced by AGE, can contribute to the inflammatory cycle by the induction of proinflammatory cytokines, via the nuclear factor-κB pathway [21]. No studies have yet ... is linked to the inflammatory response rather than to hyperglycemia. The latter is key in the AGE associated with diabetes [3]. We did not measure hemoglobin A1c in...
Ngày tải lên: 09/08/2014, 01:21