Báo cáo y học: " Pathogenesis of rheumatoid arthritis: how early is early" pdf

... [6]. Histopathologic evaluation of synovial tissue shows chronic changes shortly after the onset of symptoms, and the cytokine profile in early disease as determined by immunohistochemistry is nearly ... preclinical phase. Commentary Pathogenesis of rheumatoid arthritis: how early is early? Gary S Firestein Division of Rheumatology, Allergy and Immunology, UCSD Schoo...

Ngày tải lên: 09/08/2014, 06:23

... and cell cycle arrest on proliferation of rheumatoid arthritis synovial fibroblasts (RASFs)Effects of synchronisation and cell cycle arrest on proliferation of rheumatoid arthritis synovial fibroblasts ... otherwise noted, all data Figure 1 Proliferation capacity of rheumatoid arthritis synovial fibroblasts (RASFs)Proliferation capacity of rheumatoid arthritis synovial fibro...

Ngày tải lên: 09/08/2014, 01:22

... monitoring of the registry and to Rocío Gonzalez for her help in the statistical analysis and data management. BIOBADASER is supported by the Spanish Society of Rheumatology. This study was funded, ... traditional drugs. Because chronic therapy is nec- essary, continual review of this issue is necessary. Competing interests JJGR is on Advisory Boards of Schering-Plough, Wye...

Ngày tải lên: 09/08/2014, 08:22

... the type of CD44 isoform might dictate the pattern of the post-translational modifica- tion. The rich ligand repertoire of CD44 is possibly related to its multistructural nature. Discovery of novel ... macrophages and lymphocytes) initiated by physical injury, infection or an immune response, is normally a self-limiting episode. The inflammatory response is fostered by the upreg...

Ngày tải lên: 09/08/2014, 01:21

... regulatory pathways, particularly the NF-κB pathway. Hypoxia, or hypoxia and reoxygenation? Studies of RA synovium in vivo have suggested that synovial perfusion is influenced directly by high ... for angiogenesis in most tissues. In this review we explore the role of oxidative stress and hypoxia in the pathogenesis of rheumatoid arthritis (RA), a prototypical chronic inflammatory...

Ngày tải lên: 09/08/2014, 01:24

... arthritis (RA) synoviocytes by administration of recombinant FasL adenovirus (Ad-FasL)Efficient increase of apoptosis incidence in rheumatoid arthritis (RA) synoviocytes by administration of recombinant ... were confirmed by sequencing analysis using BigDye Terminator Ready Reaction Kits (PE Biosystems, Foster City, CA, USA). Immunohistochemistry An immunohistochemistry staining syst...

Ngày tải lên: 09/08/2014, 07:20

... methotrexate dose of the original course was low. Introduction Rheumatoid arthritis (RA) is a chronic, autoimmune, inflamma- tory disorder of unknown aetiology that is characterized by symmetric synovitis and ... recapitulated in analyses of re-employment of other DMARDs. Re-employment of MTX despite prior inefficacy, but not re-employment of other DMARDs, is an effective...

Ngày tải lên: 09/08/2014, 07:20

... albeit showing signs of degeneration and neo- vascularization at ultrasound evaluation, is usually asympto- matic, even if pain may arise as the result of peritendinitis, which is exquisitely inflammatory ... production of new collagen fibers. Studies on collagen turnover performed in humans by means of microdialysis techniques show that, after different types of exercise, both...

Ngày tải lên: 09/08/2014, 14:21

... major predictor of remission in early RA [5]. Although disease activity was not obviously more pronounced in female RA patients at the onset of disease, the disease course became markedly worse in women. Disparity ... relationships Activation of the hypothalamus-pituitary-adrenal axis by pro- inflammatory stimuli and chronic stress leads to a parallel decrease in hypothalamus-pituitar...

Ngày tải lên: 09/08/2014, 14:22

... allergic reactions and anaphylaxis. However, the activity of mast cells in health and disease is clearly much more complicated. Secretion can occur without evidence of degranulation, and even molecules ... gastrointestinal tract is characterized by a unique accumulation of immune and inflammatory cells. The mechanism of interaction between nerve and inflammatory cells in the intes...

Ngày tải lên: 08/08/2014, 20:23