Báo cáo y học: "Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis" docx
Báo cáo y học: "Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis" docx
... typically induced by externalstimuli such as certain inflammatory cytokines (IL-6, IL-1β) and by certain growth factors.Extracellularly, TIMPs inhibit MMP activity by forming high-affinity ... articleExpression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritisMaria Bokarewa1, Leif Dahlberg2 and Andrej Tarkowski11Department of ... activ-ity of MMPs is regulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs) [4]. The TIMP familyknown at present consists of four distinct members (TIMPs 1 to 4)...
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Báo cáo y học: "omparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi" pps
... recently moni tored in A.benhamiae by cDNA microarray analysis during growthon keratin, and also during cutaneous infection of gui-nea pigs [8]. Interestingly, the prominent keratininduced ... ability of dermatophytes to specifically infect superficial hoststructuresmaybesupportedbythepossessionofabroad repertoire of genes encoding hydrolytic enzymes,the expression of many of which was ... Hayden ML, Platts-Mills TA: Definition of aTrichophyton protein associated with delayed hypersensitivity in humans. Evidence for immediate (IgE and IgG4) and delayedhypersensitivity to a single...
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Báo cáo y học: "The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue" doc
... to the exploratory nature of thestudy.ResultsExpression of RasGRF1 in RA and non-RA synovial tissue To gain insight into potential involvement of RasGRF1 in RA,immunohistochemical staining ... synovial sublining by macro-phages, lymphocytes, and other immune cells, and by intimallining layer hyperplasia due to increased numbers of intimalmacrophages and fibroblast-like synoviocytes (FLS) ... family homologsare present in RA synovial tissue, and are preferentiallyexpressed in the intimal lining layer [14,15]. Activation of Raseffector pathways, including mitogen-activated proteinkinases,...
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Tài liệu Báo cáo Y học: Antibacterial and antifungal properties of a-helical, cationic peptides in the venom of scorpions from southern Africa pptx
... in the venom of scorpionsbelonging to the same family, independent of the continent and region where they live. In this study, the biologicalactivity of parabutoporin and opistoporin 1 is comparedwith ... recently described in the venom of spiders and insects.Parabutoporin and opistoporin 1 were synthesizedchemically and preliminary studies on antibacterial activityshowed that the quality and ... hydrophobicity (pandinin 1–0.1214,opistoporin 1–0.1652) and the hydrophobic moment, whichis nearly double for pandinin 1 (pandinin 1 0.1071,opistoporin 1 0.055). The amino acid substitutions highlyresponsible...
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Tài liệu Báo cáo Y học: Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis docx
... classes.Role of Tyr183 in catalysis In previous crystallographic studies it was shown that thehydroxyl side chain of Tyr183 is within hydrogen bondingdistance of the N-acetyl carbonyl oxygen of the ... protein as judged by SDS/PAGE. The activity of the pure recombinant protein was80% of that of t he wild-type protein in both the lysozyme and chitinase assays. Attempts to further purify therecombinant ... 3).CONCLUSIONS In this study we investigated the catalytic role of Asp125,Glu127 and Tyr183 in hevamine by X-ray crystallographic and kinetic analysis of several mutants. We show thatGlu127 is the proton-donating...
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Báo cáo Y học: Expression and purification of the recombinant subunits of toluene/ o-xylene monooxygenase and reconstitution of the active complex potx
... conclusively) itsregulatory role in the complex. In fact, the 3.6-fold increase in the ability of Tomo H to transform p-cresol into 4-MC, in the absence of any capability of Tomo D to transferelectrons, ... described in Materials and methods using 10 nmol of TomoH and 20 nmol of Tomo C and Tomo D.Components p-cresol converted (nmol)Tomo H 0.075Tomo C 0Tomo D 0Tomo H + Tomo C 0.173Tomo H + Tomo ... attributed to its capacity to modulate theactivity of the hydroxylase component of the complex, as itTable 1. Single-turnover assays catalyzed by the components of thetoluene/o-xylene monooxygenase...
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Báo cáo Y học: Expression and characterization of recombinant vitamin K-dependent c-glutamyl carboxylase from an invertebrate, Conus textile doc
... & Castellino, F.J. (1998) Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartatereceptor ion channel peptidic inhibitors, conantokin-G and con-antokin-T. J. ... mM) by the recombinant bovine carboxylase (closedsymbols) and the recombinant Conus carboxylase (open symbols).Incorporation of 14CO2into e-TxIX12 was measured in the presence of increasing ... min))1 in the presence of vitamin K and 181 c.p.m.Æ(30 min))1 in its absence. In thepresence of proPT18 and vitamin K, this activity increases to 10 239 c.p.m.Æ(30 min))1. Carboxylase activity...
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Báo cáo Y học: Expression and distribution of penaeidin antimicrobial peptides are regulated by haemocyte reactions in microbial challenged shrimp pptx
... the site of injectionInjection of microorganisms resulted in a dramatic decrease in numbers of both circulating and tissue in ltratinghaemocytes within 3 h of injection. To study haemocytebehaviour ... Regarding phagocytosisreactions, internalized bacteria were observed after 20 minincubation mainly into hyaline haemocytes (Fig. 10I).Intracellular phagocytosed bacteria observed in hyalinecells ... C2).Localization of penaeidin expression and storage in shrimp tissues after microbial challenge In order to investigate the ability of tissues other thanhaemocytes to express penaeidins and to study the...
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Báo cáo Y học: Structural and functional characterization of a C-type lectin-like antifreeze protein from rainbow smelt (Osmerus mordax) potx
... trypsin, untreated AFP (UT AFP), and deglycosylated AFP (DG) are id entified.Bands smaller than 1 4 kDa in lan es containing trypsin were shown to b e trypsin autolysis products (trypsin-only ... [19].Dimerization of smelt AFP is unlikely to increase activityby increased ice binding because only a dimer with perfectlyaligned ice-binding sites would have enhanced binding to ice and this is not likely ... Ca2+-binding molecular mass standardb-lactoglobulin (not shown). The specificity of binding isdemonstrated by the absence of detectable ruthenium redstaining when CaCl2is added to the staining...
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Báo cáo khoa học: Expression and functional characterization of P2Y1 and P2Y12 nucleotide receptors in long-term serum-deprived glioma C6 cells ppt
... FEBSImmunocytochemistry analysis of f-actin and vinculin distributionThe distribution of vinculin was assessed with a primaryantibody against vinculin (Sigma) detected by secondaryantibody conjugated ... the P 2Y 12receptor. On the otherhand, Akt phosphorylation increased in parallel with the low expression of the P 2Y 1receptor, indicating the inhibitory role of P 2Y 1 in Akt pathwaysignaling. ... of P 2Y 12 in mitogen-activatedprotein kinase and Akt kinase signaling pathways.On the other hand, the functional activity of theP 2Y 1receptor in long-term serum-starved cells wasrecently...
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