Báo cáo y học: "Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis" docx

... typically induced by external stimuli such as certain inflammatory cytokines (IL-6, IL-1β) and by certain growth factors. Extracellularly, TIMPs inhibit MMP activity by forming high- affinity ... article Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis Maria Bokarewa 1 , Leif Dahlberg 2...

Ngày tải lên: 09/08/2014, 06:23

... recently moni tored in A. benhamiae by cDNA microarray analysis during growth on keratin, and also during cutaneous infection of gui- nea pigs [8]. Interestingly, the prominent keratin induced ... ability of dermatophytes to specifically infect superficial host structuresmaybesupportedbythepossessionofa broad repertoire of genes encoding hydrolytic enzymes, the expression of man...

Ngày tải lên: 09/08/2014, 22:23

... to the exploratory nature of the study. Results Expression of RasGRF1 in RA and non-RA synovial tissue To gain insight into potential involvement of RasGRF1 in RA, immunohistochemical staining ... synovial sublining by macro- phages, lymphocytes, and other immune cells, and by intimal lining layer hyperplasia due to increased numbers of intimal macrophages and fibr...

Ngày tải lên: 09/08/2014, 14:22

... in the venom of scorpions belonging to the same family, independent of the continent and region where they live. In this study, the biological activity of parabutoporin and opistoporin 1 is compared with ... recently described in the venom of spiders and insects. Parabutoporin and opistoporin 1 were synthesized chemically and preliminary studies on antibacterial acti...

Ngày tải lên: 21/02/2014, 15:20

... classes. Role of Tyr183 in catalysis In previous crystallographic studies it was shown that the hydroxyl side chain of Tyr183 is within hydrogen bonding distance of the N-acetyl carbonyl oxygen of the ... protein as judged by SDS/ PAGE. The activity of the pure recombinant protein was 80% of that of t he wild-type protein in both the lysozyme and chitinase assays. Attemp...

Ngày tải lên: 22/02/2014, 04:20

... conclusively) its regulatory role in the complex. In fact, the 3.6-fold increase in the ability of Tomo H to transform p-cresol into 4-MC, in the absence of any capability of Tomo D to transfer electrons, ... described in Materials and methods using 10 nmol of Tomo H and 20 nmol of Tomo C and Tomo D. Components p-cresol converted (nmol) Tomo H 0.075 Tomo C 0 Tomo...

Ngày tải lên: 17/03/2014, 10:20

... & Castellino, F.J. (1998) Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl- D -aspartate receptor ion channel peptidic inhibitors, conantokin-G and con- antokin-T. J. ... m M ) by the recombinant bovine carboxylase (closed symbols) and the recombinant Conus carboxylase (open symbols). Incorporation of 14 CO 2 into e-TxIX12 was measured in the pres...

Ngày tải lên: 17/03/2014, 10:20

... the site of injection Injection of microorganisms resulted in a dramatic decrease in numbers of both circulating and tissue in ltrating haemocytes within 3 h of injection. To study haemocyte behaviour ... Regarding phagocytosis reactions, internalized bacteria were observed after 20 min incubation mainly into hyaline haemocytes (Fig. 10I). Intracellular phagocytosed bacteri...

Ngày tải lên: 18/03/2014, 01:20

... trypsin, untreated AFP (UT AFP), and deglycosylated AFP (DG) are id entified. Bands smaller than 1 4 kDa in lan es containing trypsin were shown to b e trypsin autolysis products (trypsin-only ... [19]. Dimerization of smelt AFP is unlikely to increase activity by increased ice binding because only a dimer with perfectly aligned ice-binding sites would have enhanced binding to ice...

Ngày tải lên: 24/03/2014, 03:21

... FEBS Immunocytochemistry analysis of f-actin and vinculin distribution The distribution of vinculin was assessed with a primary antibody against vinculin (Sigma) detected by secondary antibody conjugated ... the P 2Y 12 receptor. On the other hand, Akt phosphorylation increased in parallel with the low expression of the P 2Y 1 receptor, indicating the inhibitory role of P 2Y 1...

Ngày tải lên: 30/03/2014, 08:20