Báo cáo y học: "Accelerated development of arthritis in mice lacking endothelial selectins" pdf
... established cytokine in RA pathology, TNF-α was not detected in any mice at any of the time points measured in the study. This cytokine may not be necessary for the development of arthritis in this ... potential influence of selectins on the pattern of cytokine expression during the chronic phase of CIA, cytokines were measured in the joints of mice with CIA at d...
Ngày tải lên: 09/08/2014, 06:23
... A, alanine; L, leucine; T, threonine; Y, tyrosine; εACA, ε-aminohexanoic acid-lysine-lysine- tyrosine-glycine-OH. b Absorbance at 405 nm in ELISA tested with affinity-purified mAbs. In the ELISA ... Chlorination of pyridinium compounds. Possible role of hypochlorite, N-chloramines, and chlorine in the oxidation of pyridinoline cross-links of articular cartilage collagen type I...
Ngày tải lên: 09/08/2014, 07:20
... Collagen-induced arthritis Species Rat Mouse Rat Dose 1 mg/kg/day 6.4 mg/kg/day 3 mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duration 7 days 35 days 5 days Effect on inflammation ... consequently lead to increasing inter- est in the role of osteoclasts in local bone erosion that is driven by the hypothesis that synovial pannus makes use Review The role...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "arly development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution" pps
... elevations in circulating free immunoglobulin light chains in serum may be a sensitive marker for pre- dicting NHL in HIV-infected patients, w hich may be a useful screening tool in patients at increased ... findin g of symptomatic NHL occurring in the setting of profound HIV viral load decline following initiation of HAART. This phenomenon raises the question of whether the...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient
... enhanced in 1% copper sulphate for 10min. Finally, sections were counterstained in Mayer’s haematoxylin, dehydrated through the as- cending graded alcohols, cleared in xylol and finally coverslipped ... feature of various cancers including cancer of the co- lon [33]. The amino acid analysis of the purified mucin gave high amounts of ‘mucin-like amino acids, serine, threoni...
Ngày tải lên: 26/10/2012, 10:03
Báo cáo y học: " Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphis"
... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... pathogenesis of AML. During sequence analysis of exon 10 in the AML samples we identified a new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 heal...
Ngày tải lên: 31/10/2012, 16:49
Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in thi...
Ngày tải lên: 31/10/2012, 17:11
Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... determinant for the transcrip- tional regulation of the drug metabolizing enzyme family of heme-containing monooxygenases P450 CYP3A [1–4]. Consequently this nuclear receptor is likely to play a ... the histidine residue makes a hydrogen bond to SR12813 in one of its binding modes. The mutation of this residue gave a number of surprising results suggesting that this residue play a...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... to ligation of the thiol group of coenzyme M. Mutations in His237 or Cys239, which are proposed to be involved in ligating zinc, resulted in an over 90% loss in enzyme activity and in distinct changes in ... & Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: Stimulated biosynthesis of flavins in Photobacterium phosphoreum IFO 13896 and the presence of complete rib operons in two species of luminous bacteria Sabu Kasai and Takumi Sumimoto pot
... Chemistry, Faculty of Engineering, Osaka City University, Japan Photobacterium phosphoreum IFO 13896 emits light strongly when cultured in medium containing 3% NaCl, but only weakly in medium containing ... pyrimidine deaminase/pyrimidine reductase, riboflavin synthase, GTP cyclohydrolase II/3,4-dihydr- oxy-2-butanone 4-phosphate synthase, and lumazine syn- thase. The genes coding for th...
Ngày tải lên: 31/03/2014, 08:20