Báo cáo y học: "Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens" ppt

... osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens Martin Schmidt 1 *, ... (similar in OA and RA). Surprisingly, levels of E2, E3, and 16α-hydroxylated steroids were as high as levels of testosterone. In RA and OA, 5α-...

Ngày tải lên: 09/08/2014, 06:23

... specifically by the HAQ: dressing and grooming, arising, eating, walking, hygiene, reach, grip, and common daily activities. For each of these domains, patients report the amount of difficulty they have ... variety of clinical settings including the community, university set- tings, and private practices, prospectively collected, and encompassing a long period. We have presented...

Ngày tải lên: 09/08/2014, 01:24

... 1 1–1 6 14 1 3–1 5 Diabetes mellitus b 10 8–1 2 7 6–8 Smoking ever a 68 6 5–7 1 37 3 5–3 8 Smoking now a 26 2 3–2 9 15 1 4–1 7 Body mass index ≥30 a 13 1 1–1 5 19 1 8–2 0 Physical inactivity d 68 6 5–7 1 73 7 2–7 5 a P ... MONICA (Multinational Moni toring of Trends and Determinants in Car- diovascular Disease) project, in which the highest rates of myocardi...

Ngày tải lên: 09/08/2014, 10:23

... as a potent lipooxygenase inhibitor. The results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this ... modifying effect in osteoarthritis. Further studies are required both to confirm the symptomatic efficacy and acceptable safety profile and to evaluate the potential chondromodulati...

Ngày tải lên: 09/08/2014, 11:20

... growing interest in the issue of self-harm and wider recognition of its existence. The increasing coverage of self-harm in the mainstream media and within clinical journals reflects this growing interest ... people and mental health services: Treading Water. Open Mind 2002, 114:19. 5. Raleigh VS: Suicide patterns and trends in people of Indian subcontinent and Caribbea...

Ngày tải lên: 08/08/2014, 21:20

... 1 Effect of protein kinase inhibitors and LY83583 on endothelin-1 (ET-1)-induced MMP-13 and MMP-1 production by human osteoarthritis chondrocytesEffect of protein kinase inhibitors and LY83583 ... NO production was partially suppressed by the p38 kinase inhibitor and was completely suppressed by the protein kinase A kinase inhibitor KT5720 and by LY83583, suggesting the in...

Ngày tải lên: 09/08/2014, 06:22

... conventional pain coping skills training and pain coping skills training with a maintenance training com- ponent: A daily diary analysis of short- and long-term treat- ment effects. J Pain 2006, 7:615-625. 25. ... depressive symptoms, even more so than activity losses in other domains [22]. The role of leisure in maintaining or restoring psychological well- being in the presen...

Ngày tải lên: 09/08/2014, 08:23

... using this stringent method. The EIRA study included mainly individuals born in Sweden. Taking those born outside Sweden into consideration also, 97% were of Caucasian origin. In order to minimize ... can readily cross the cell membrane and inactivate protein tyrosine phosphatases, including that encoded by PTPN22, through oxidation of a specific cysteine residue [54]. ROS producti...

Ngày tải lên: 09/08/2014, 10:21

... biomarkers by transcript profiling of peripheral circulating lymphocytes. As an initial proof -of- concept, we demonstrated the feasibility of such technology by successful profiling PBMCs in a rat CIA model. ... demonstrable in mice and monkeys), immunization with type II collagen (CII) – the collagen found in joint cartilage – induces T cell activation, anti-CII autoanti...

Ngày tải lên: 09/08/2014, 07:20

... confirmatory findings in other settings. A high body mass index was strongly and selectively associ- ated with increased risk of anti-CCP-negative RA, a finding that has not been reported previously. ... birth year, and year or pseudo-year of RA diagnosis. b Adjusted for gender, birth year, year or pseudo-year of RA diagnosis, place of residence, educational status, history o...

Ngày tải lên: 09/08/2014, 08:22