Báo cáo y học: "NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis" docx

... of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF- κ B- and PI3-kinase/Akt-dependent pathways Sue-Yun Hwang 1 , Ju-Young Kim 1 , Kyoung-Woon Kim 1 , Mi-Kyung Park 1 , Youngmee ... signaling in human monocyte cell line [10] and embryonic fibroblasts [11], respectively, and yet cytoplasmic players transmitting IL-17-mediated activation in R...

Ngày tải lên: 09/08/2014, 01:23

... ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection. Arthritis Res 2001, 3:253-258. 15. Adler SP, McVoy M: Detection of cytomegalovirus antibody by enzyme immunoassay and lack of evidence for ... which cross-react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis. Immunology 1992, 75:513-519....

Ngày tải lên: 09/08/2014, 06:22

... with proinflam- matory properties [5,22]. RA is characterized by hyperpla- sia of synovial lining cells and an intense infiltration by mononuclear cells [23]. Proinflammatory cytokines such as IL-1 ... NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC. In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines...

Ngày tải lên: 09/08/2014, 06:22

... article NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis Peter ... WT mice, chondrocyte death was completely absent at day 3 and was only very low at day 7 (between 2 and 5% in the tibia and...

Ngày tải lên: 09/08/2014, 06:23

... upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and production of these three chemokines ... expressed CCL5 protein (Figure 6). In addition, staining was demonstrated at the synovial lining and on many infiltrating inflammatory cells. Protei...

Ngày tải lên: 09/08/2014, 07:20

... also induce monocyte CC and CXC chemokine production in a contact-dependent manner. The transcription factor NFκB is differentially involved in this process as CXC chemokines but not CC chemokines ... con- tact-dependent induction of CC and CXC chemokines in monocytes is surprising and indicates that chemokine gene expression may be more complex than previo...

Ngày tải lên: 09/08/2014, 08:23

... http://arthritis-research.com/content/8/6/R189 Page 1 of 8 (page number not for citation purposes) Vol 8 No 6 Research article Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular ... and SIN-1 in chondrocytes. Conclusion By amplifying distinct ROS-dependent destructive pathways in cartilage...

Ngày tải lên: 09/08/2014, 08:23

... was elevated on day 3 in tibial cartilage and on days 3 and 7 in patellar cartilage, but no longer was by day 21. Increased NITEGE staining (indicating aggrecanase activity) was found on days 7 and ... production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodel...

Ngày tải lên: 09/08/2014, 10:21

... albicans infection of prostaglandin E2 (PGE 2 ) production by synovial fibroblastsThe effect of Candida albicans infection of prostaglandin E2 (PGE 2 ) production by synovial fibroblasts. Synovial ... evaluated by an electrophoretic mobility shift assay. Results Infection of synovial fibroblasts with C. albicans resulted in cyclo-oxygenase 2 expressio...

Ngày tải lên: 09/08/2014, 14:20

... Access Decreased GABA B receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation Thoppil R Anju, Sadanandan Jayanarayanan and Cheramadatikudiyil ... GABA B receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, ox...

Ngày tải lên: 10/08/2014, 05:21

... Hyperbaric oxygen therapy as an adjunctive treatment for sternal infection and osteomyelitis after sternotomy and cardiothoracic surgery. Journal of Cardiothoracic Surgery 2011 6:141. Yu et al. ... stay, and duration of MV and NIV s upport. Furthermore, it also reduced complications during hospi tal stay and mortality in patients with sternal infection...

Ngày tải lên: 10/08/2014, 09:22

... as: Mossberg et al.: Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome. Journal of Inflammation 2010 7:40. Submit your next manuscript to BioMed ... respiratory burst in leukocytes is strongly associated with a severe course of RGBS. Introduction The recurrent Guillain-Barré syndrome ( RGBS) is a demyelinating...

Ngày tải lên: 11/08/2014, 03:20

... as: Mossberg et al.: Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome. Journal of Inflammation 2010 7:40. Submit your next manuscript to ... supplementary mechanism relates to the regulatory effects of oxygen radicals on T cells and other subsets of lymphocytes. Phagocyte-derived oxygen radicals efficiently tr...

Ngày tải lên: 11/08/2014, 06:22

... study to examine the proteoglycan production in both centrally and distally derived fibroblasts from COPD patients. In our study, an alteration in proteoglycan production was observed in fibroblasts ... total amount of proteoglycan production. Surprisingly, these data are consistent with a rat model investigating bleomy- cin-induced pulmonary fibrosis, which showed that big...

Ngày tải lên: 12/08/2014, 11:21

... Netherlands. Abstract Background: The present study was undertaken to examine the feasibility of venous oxygen measurements in the inferior vena cava (IVC) via a catheter through the umbilical vein. This may serve as a proxy ... of oxygen for low birthweight infants causes retinopathy of prematu- rity, while extreme lack of oxygen leads to death. Chronic deficiency o...

Ngày tải lên: 12/08/2014, 18:20