Báo cáo y học: "Perforin deficiency attenuates collagen-induced arthritis" doc

... Immunology, University of Rostock, Rostock, Germany 2 Institute of Pathology, University of Rostock, Rostock, Germany 3 Institute of Neurology, University of Rostock, Rostock, Germany 4 Section ... collagen type II; CTL = cytotoxic T lymphocyte; EAE = experimental autoimmune encephalomyelitis; ELISA = enzyme-linked immunosorbent assay; FITC = fluorescein isothiocyanate; H & E = hematoxy...

Ngày tải lên: 09/08/2014, 06:23

... and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte aggregates with germinal centres (GCs) [19–21]. These ectopic lymphoid struc- tures share many features ... B lymphocytes and a subset of memory CD4 + T lympho- cytes, whereas the expression of its ligand, BCA-1, is mainly confined to B-cell follicles [27–30]. Mice deficient in CXCR5 or B-lymphocy...

Ngày tải lên: 09/08/2014, 03:24

... finally lead to severe pulmonary hypertension, right ventricular hypertrophy and right heart failure, resulting in high morbi dity and mortality [3]. Generally, there are 5 subsets of pulmonary hypertens ... Rubin LJ: Pathology and pathophysiology of primary pulmonary hypertension. Am J Cardiol 1995, 75(3):51A-54A. 6. Archer S, Rich S: Primary pulmonary hypertension: a vascular biology and tr...

Ngày tải lên: 12/08/2014, 13:22

... beyond the scope of this study; however the biological advantage to this type of response is not obvious. A more likely option is that the physical force imposed by compression physi- cally altered ... the airway epithelium to denudation and mechanical compression independently, they are closely linked both temporally and spatially in vivo [12,16]. A single study encompassing both types of ep...

Ngày tải lên: 12/08/2014, 14:20

... inflammatory mediators, exemplified by key pro- inflammatory interleukin(IL)-6 and IL-8, by airway epi- thelial cells have shown that reduced levels of the essential amino acid tryptophan, which ... amino acid, acquired by eukaryotic cells by syn- thesis in the Krebs urea cycle and uptake via the cationic amino acid transporters (CAT; [10-14]). CATs are blocked by polycations like major basic...

Ngày tải lên: 12/08/2014, 14:20

... asthma [12] and systemic lupus erythematosus [13], overexpression of cytotoxic molecules by systemic CD8 + T lymphocytes or other types of lymphocytes may also lead to non-specific systemic damages ... Expression of perforin, granzyme B, and FasL protein by CD8 + T lymphocytes, CD4 + T lymphocytes, and natural killer cells were assessed by flow cytometry while perforin, granzyme B, and Fas...

Ngày tải lên: 12/08/2014, 15:21

... concept that at any given plasma concentration of drug, the final efficacy may be significantly affected by the hormone status of the patient. Most likely, β-estradiol acts by modifying intrac- ellular ... DA, Aquaro S, Humphrey RW, Calio R, Yarchoan R: Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect...

Ngày tải lên: 13/08/2014, 05:21

... care unit. Key messages • Hyperfibrinolysis may play a role in inflammatory response (IR) after cardiopulmonary bypass (CPB). • Inhibition of fibrinolysis with tranexamic acid may attenu- ate ... Horacek M, Vislocky I: A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmo- nary bypass and a possible early sign of systemic inflamma- tion syndrome. Eur J ......

Ngày tải lên: 13/08/2014, 08:21

... pul- monary edema caused by short periods of cyclic overinflation. J Appl Physiol 1992, 72:2081-2089. 19. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS: Injurious ven- tilatory strategies ... active Na + transport by cultured monolayers of pulmonary alveolar epithelial cells. Am J Physiol Cell Physiol 1983, 245:C78-C83. Key messages • The increased clearance of pulmonary oedema resul-...

Ngày tải lên: 13/08/2014, 08:21

... phosphatases play relevant roles in the biology of the yeast (cell integrity, cell c ycle regulation, cation homeostasis, etc) and that they interact with several key signalling pathways. In some ... residues directly following the conserved catalytic domain. This extension has no similarity with the C-terminal extension of type 2B catalytic subunits and ends with the highly conserved DYFL se...

Ngày tải lên: 17/03/2014, 23:20