... of intracellularsignaling of the Jak–STAT pathway used by several cyto-kines. They act by inhibiting the kinase activity, by competingwith substrates needed for signal transduction, and bytargeting ... exclusively by stromal cells in the thymus and lymph nodes, by lymph vessels in the intestine and by the epidermis [32]. In CCX-CKR–/–mice,trafficking of dendritic cells to lymph nodes under steady-state ... that the main problem is in fact the inhibition of repair activity. Any type of chronic joint inflammation, whetherinfectious, inflammatory, or autoimmune, will result in jointdestruction within...