Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

... monocytes may also be contributing to the pathol- ogy of other inflammatory autoimmune diseases. Such a corollary suggests it may be of interest to investigate mtDNA within other inflammatory autoimmune ... fibroblast lines. YM participated in the molecular genetic studies and analysis. EK procured the sam- ples and helped in the analysis of data. GW participated in the...

Ngày tải lên: 09/08/2014, 06:23

... Beer Y: Interleukin-17 enhances tumor necro- sis factor alpha-induced synthesis of interleukins 1,6, and 8 in skin and synovial fibroblasts: a possible role as a ‘fine-tuning cytokine’ in inflammation ... anti- IL-15 therapy in RA patients [29]. T helper 17 cells There is increasing evidence that IL-17 plays a role in the immunopathology of RA. This proinflammatory cytokine is...

Ngày tải lên: 09/08/2014, 10:22

... in the inflamed joint or in the lymph nodes via clearance of vectors or transgenes to the lymphatic system. In RA patients the draining lymph nodes of inflamed foot joints had higher levels of proinflammatory ... around the fact that the rheumatoid factors in RA patients may form immune complexes with the immunoglobulin domain of the tgAAC94 fusion protein, t...

Ngày tải lên: 09/08/2014, 01:24

... Leber’s hereditary optic neuropathy are caused by inherited (germline) mutations of mtDNA. They comprise a wide spectrum of clinical symptoms that arise as a result of dysfunction of the mitochondrial ... recognized as non-self by the immune system. Further studies will show whether these mutations are actually able to trigger autoimmune inflammation in rheumatoid arthrit...

Ngày tải lên: 09/08/2014, 07:20

... purposes) of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... and lamotrigine. The triad of hypersensi- tivity includes fever, rash and internal organ involvement with onset of symptoms within 1 to 8 weeks of exposure. The freque...

Ngày tải lên: 25/10/2012, 10:51

... be the start of the protein coding domain. Sequence analysis of the 3¢ end cDNA revealed that there is a polyadenylation signal upstream of the poly(A). Analysis of the primary structure of M. ... 2002 Recently, the a subunit of a G protein of the Gq family has been immunolocalized in olfactory sensilla preparations of the silkmoth Antherea pernyi [23]. Using...

Ngày tải lên: 17/03/2014, 23:20

... depressive symptoms, even more so than activity losses in other domains [22]. The role of leisure in maintaining or restoring psychological well- being in the presence of arthritis pain warrants further study. Psychosocial ... A comparison of conventional pain coping skills training and pain coping skills training with a maintenance training com- ponent: A daily diary analys...

Ngày tải lên: 09/08/2014, 08:23

... concerning the role of T lymphocytes, B lymphocytes, dendritic cells, and other antigen-presenting cells (APCs) in the pathophysiology of IIMs. T lymphocytes T lymphocyte function T lymphocytes ... demonstrated the presence of differentiated B lymphocytes in the form of CD138 + plasma cells predominantly in the endomysium of muscle tissue of patients with polymyosi...

Ngày tải lên: 09/08/2014, 10:20

... tissues acting to increase the excitability of the nociceptive pathway and has the effect of making everyday Review Arthritis and pain Current approaches in the treatment of arthritic pain Bruce ... therapeutic utility, it has served to maintain the Cartesian concept of a fixed immutable pain system that faithfully transmits information from a site of injury to pain ce...

Ngày tải lên: 09/08/2014, 10:20

... explained in the following way. The chance of finding a seed-match and of producing a local alignment of significant similarity rises with the length of the frag- ment. Longer fragments, then, ... sequences include only a small proportion of microbes found in nature [14]. Finally, the target genome used for detection of fragments of interest may not be sufficiently...

Ngày tải lên: 09/08/2014, 20:22