Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... CD4+CD25+Treg and detected an accumulation in the inflamed joints, thusexcluding the possibility that the lack of therapeutic activitywas due to the inability of CD4+CD25+Treg to migrate intothe inflamed ... adoptive transfer of preactivated CD4+CD25+Treg can prevent the induction of autoimmunity but cannot ‘cure’ animals with ongoingautoimmunity. Thus it seems that the thresholds to controlinduction ... thatwhen studying CD4+CD25+Treg we have to bear in mindthe compartment (tissue) that Treg are obtained from. Indeed,it is apparent that, to gain significant results, studies onCommentaryRole...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... demonstrate nonana-phylactogenic activity by blocking of IgE binding. IL-10reduces release of proinflammatory cytokines by mast cells. The role of IL-10 in costimulatory pathways on B cells isby ... targeting T cells in the treatment of allergy and asthma. Curr Opin Immunol 2006;18:745–50.18. Hawrylowicz CM, O’Garra A. Potential role of IL-10-secreting regulatory T cells in allergy and asthma. ... surface to other cells of the immunesystem, especially to CD4+ T helper (Th)2 cells. Thisresults in Th2-type cytokine production (interleukin [IL]-4, IL-13), which causes class switching of B cells...
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Báo cáo y học: " Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis" ppsx
... detection of TRAP for osteoclastactivity and of osteocalcin for osteoblast activity. Representa-tive images of the different skeletal regions showing osteo-clasts and osteoblasts simultaneously are ... tartrate-resistant acidic phosphatase(TRAP) labeling for detection of osteoclasts and osteocalcin in- situ hybridization for detection of osteoblasts. Sectionswere first stained with TRAP (leukocyte ... of thesedata, the hypothesis that the inflammatory events in RA prima-rily lead to activation of osteoclasts and bone resorption bymeans of TNF and RANKL, but do not induce the osteoblastcompartment...
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Báo cáo y học: " Role of Dietary Soy Protein in Obesity"
... increasing the amount of dietary protein content from 15% to 30% of total energy while maintaining the carbohydrate con-tent (50 %of total daily caloric intake) in the diet re-sulted in sustained ... for the prevention and treatment of obesity. 3. Nutrient composition of soy protein Soybeans provide one of the most abundant plant sources of dietary protein. The protein content of soybeans ... liver triglycerides or fat by partly inhibiting hepatic fatty acid synthesis in the liver. ACC, the rate-limiting en-zyme that catalyzes the carboxylation of acetyl-Co A to form malonyl-CoA,...
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Báo cáo Y học: Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase Differential stabilization of FAD redox forms doc
... not involved in any intraproteininteraction, but is situated at the entrance of a watercavity, at the bottom of which are the pyrophosphate and the ribose from the FAD. Therefore, K75 cannot ... concerning factors that contribute totune the reduction potential of the flavin within the proteinenvironment. Thus, our results suggest that some side-chains may modulate the reduction potential ... reactivity of this E301AFNR mutant in complex formation and ET to its substrateshad already indicated that the lack of its semiquinonestabilization was the cause for its highly impaired ET ability,as...
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Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
... budes-onide treatment demonstrated a trend toward betterprotection than did montelukast treatment at threepostexercise time points (2, 7, and 12 minutes), butthe difference was significant only at the ... protectionagainst EIB during the first 3 days of treatment witheither montelukast or salmeterol, but again, the pro-tection was lost in the salmeterol group after 4weeks of treatment. Protection was ... potent.5The cysteinylleukotrienes exert their biologic effects by bindingto cysteinyl leukotriene receptors (specificallyReview ArticleRole of Leukotriene Receptor Antagonists in the Treatment...
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Báo cáo y học: " Role of dopamine D2 receptors in ischemia/ reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes" potx
... ischemia/reperfusion. (A) MTT assay for cell viability. (B) DNA fragmentation determined by quantitative TUNELstaining of apoptotic cardiomyocytes. (C) Flow cytometry analysis.Li et al. Journal of Biomedical ... were stained with propi-dium iodide for 30 min at 4°C. The fluorescence of the cells was analyzed by flow cytometry. The percentage of apoptotic cells was determined using Mod Fit LT soft-ware ... receptor mediated celldeath initiation process. Stimulation of death receptors of the tumor necrosis factor receptor superfamily (Fas and TNF receptor) results in activation of the initiator...
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Báo cáo sinh học: " Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection" pdf
... performed thisstudy with the aim of identifying these cellular proteinsinteracting with 3' UTR RNA of PRRSV and to study theirrole in viral infection. In this study, we identified a PRRSV ... dehydrogenase was also reported to interact withhepatitis A virus RNA [29]. These studies indicate thathost proteins interacting with 3' UTR RNA of viruses playa very important role in ... as determined by fluorescentstaining) by the transfection of siRNA against CD151{Fig. 6B (2)}.Blocking activity of anti-CD151 Ab on PRRSV infection into MARC-145 cells To investigate the effect...
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Báo cáo khoa học: "Role of mucosal mast cells in visceral hypersensitivity in a rat model of irritable bowel syndrome" ppt
... found between vicinity of MMC to nerves and the severity of abdominal pain/discomfort symptom of IBS [3]. Thesefindings, together with our current observation, suggest thatthe degranulation of MMC ... sensoryneuron [4]. Although it is beyond the scope of the presentstudy to identify the most important mast cell mediators thatare responsible for visceral hypersensitivity in IBS, it isworthy to ... in stressed rats [13].It is interesting that about a half of MMC is in thedegranulated state in normal rat colon, and this degranulationrate is reduced to 31.3±2.4% by the pretreatment of doxantrazole...
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