Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx

... CD4 + CD25 + Treg and detected an accumulation in the inflamed joints, thus excluding the possibility that the lack of therapeutic activity was due to the inability of CD4 + CD25 + Treg to migrate into the inflamed ... adoptive transfer of preactivated CD4 + CD25 + Treg can prevent the induction of autoimmunity but cannot ‘cure’ animals with ongoing autoimmunity. Thus it seems tha...

Ngày tải lên: 09/08/2014, 06:23

... demonstrate nonana- phylactogenic activity by blocking of IgE binding. IL-10 reduces release of proinflammatory cytokines by mast cells. The role of IL-10 in costimulatory pathways on B cells is by ... targeting T cells in the treatment of allergy and asthma. Curr Opin Immunol 2006;18:745–50. 18. Hawrylowicz CM, O’Garra A. Potential role of IL-10-secreting regulatory...

Ngày tải lên: 08/08/2014, 21:20

... detection of TRAP for osteoclast activity and of osteocalcin for osteoblast activity. Representa- tive images of the different skeletal regions showing osteo- clasts and osteoblasts simultaneously are ... tartrate-resistant acidic phosphatase (TRAP) labeling for detection of osteoclasts and osteocalcin in- situ hybridization for detection of osteoblasts. Sections were...

Ngày tải lên: 09/08/2014, 07:20

... increasing the amount of dietary protein content from 15% to 30% of total energy while maintaining the carbohydrate con- tent (50 %of total daily caloric intake) in the diet re- sulted in sustained ... for the prevention and treatment of obesity. 3. Nutrient composition of soy protein Soybeans provide one of the most abundant plant sources of dietary protein. The...

Ngày tải lên: 31/10/2012, 14:59

... not involved in any intraprotein interaction, but is situated at the entrance of a water cavity, at the bottom of which are the pyrophosphate and the ribose from the FAD. Therefore, K75 cannot ... concerning factors that contribute to tune the reduction potential of the flavin within the protein environment. Thus, our results suggest that some side- chains may modulate the reduction...

Ngày tải lên: 08/03/2014, 23:20

... budes- onide treatment demonstrated a trend toward better protection than did montelukast treatment at three postexercise time points (2, 7, and 12 minutes), but the difference was significant only at the ... protection against EIB during the first 3 days of treatment with either montelukast or salmeterol, but again, the pro- tection was lost in the salmeterol group after 4 weeks of t...

Ngày tải lên: 08/08/2014, 20:23

... ischemia/reperfusion. (A) MTT assay for cell viability. (B) DNA fragmentation determined by quantitative TUNEL staining of apoptotic cardiomyocytes. (C) Flow cytometry analysis. Li et al. Journal of Biomedical ... were stained with propi- dium iodide for 30 min at 4°C. The fluorescence of the cells was analyzed by flow cytometry. The percentage of apoptotic cells was determine...

Ngày tải lên: 10/08/2014, 05:21

... performed this study with the aim of identifying these cellular proteins interacting with 3' UTR RNA of PRRSV and to study their role in viral infection. In this study, we identified a PRRSV ... dehydrogenase was also reported to interact with hepatitis A virus RNA [29]. These studies indicate that host proteins interacting with 3' UTR RNA of viruses play a very importan...

Ngày tải lên: 18/06/2014, 18:20

... found between vicinity of MMC to nerves and the severity of abdominal pain/discomfort symptom of IBS [3]. These findings, together with our current observation, suggest that the degranulation of MMC ... sensory neuron [4]. Although it is beyond the scope of the present study to identify the most important mast cell mediators that are responsible for visceral hypersensitivity in...

Ngày tải lên: 07/08/2014, 18:20