Báo cáo y học: "α Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification" pps

... placebo-controlled trial [2] and afterwards Commentary Tumor necrosis factor- αα blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification? Filip Van den ... colleagues seem to indicate that at least for the vast majority of ankylosing spondylitis patients treatment with infliximab can not be withdrawn...

Ngày tải lên: 09/08/2014, 06:23

... homeostatic maintenance of cartilage and for bringing about repair to damaged cartilage. Maintaining integrity of the nuclear material is critical, and the repair of damaged DNA is dependent on PARP. ... viability is maintained in the presence of tumor necrosis factor alpha (TNF-α) and /or epidermal growth factor (EGF)Cell viability is maintained in the presence of tumor necrosis...

Ngày tải lên: 09/08/2014, 06:22

... receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest 2005, 115:2192-2201. 49. Hirano K, Kuwasako T, Nakagawa-Toyama Y, Janabi M, Yamashita S, Matsuzawa ... biological therapies, such as anti -tumor necrosis factor alpha (anti- TNFα), provides a means of preventing high cardiovascular mortality among RA patients [4,5]. ABCA1 = ATP-b...

Ngày tải lên: 09/08/2014, 10:20

... months, Kalla and colleagues [12] reported significant effects on metacarpal cortical width with sulphasalazine, antimalarials and injectable gold. Of interest, the manual technique of metacarpal morphometry ... morphometry employed in these three old studies is identical with that measured by modern day automated radiogrammetry. Moreoever, automated radiogrammetry using hand X-rays shows...

Ngày tải lên: 09/08/2014, 10:20

... tumor necrosis factor (ligand) superfamily; TRAF, tumor necrosis factor receptor-associated factor; TTRAP, tumor necrosis factor receptor-associated factor and tumor necrosis factor receptor-associated ... 5'-GGT- GCTCTTGCTCTGTAGGG-3', STEAP4 sense 5'-GCTCTC- CAGTCAGGAGCACT-3' and antisense 5'- CACACAGCACAGCAGACAAA-3', and GAPDH sense 5'- G...

Ngày tải lên: 09/08/2014, 14:22

... Poole AR: Enhanced cleavage of type II col- lagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997, 99:1534-1545. 31. Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa ... well as the a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, such as ADAMTS- 4 (aggrecanase-1) and ADAMTS-5 (aggrecanase-2), must also be involved in cytokin...

Ngày tải lên: 09/08/2014, 14:22

... Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I: Visfatin: A protein secreted by visceral fat that ... cardiovascular disease. Nat Clin Pract Cardiovasc Med 2006, 3:35-42. 3. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Wa...

Ngày tải lên: 10/08/2014, 05:21

... mature enzyme forms after phorbol ester treatment. Keywords:ADAM10;Alzheimer’sdisease;furin;PC7; TACE. ADAMs (a disintegrin and metalloproteinases) are a family of integral type I membrane glycoproteins ... by a well defined domain structure, consisting of a N-terminal prodomain followed by a metalloproteinase domain, a disintegrin domain, a cysteine rich domain, which usually c...

Ngày tải lên: 08/03/2014, 02:20

... tumor necrosis factor -a receptor associated death domain to the intracellular death domain of TNF-R1. TNF-R1-bound tumor necrosis factor -a receptor associated death domain serves as platform for ... Swarup Centre for Cellular and Molecular Biology, Hyderabad, India Tumor necrosis factor -a (TNF -a) is a multifunctional cytokine that plays an important role in the immune r...

Ngày tải lên: 16/03/2014, 05:20

... (selective TNFR2 activation) reduced IjBa phosphorylation[56], thus indicating that the phosphatidylinositol 3-kinase- protein kinase B ⁄ serine-threonine kinase pathway may play a major role in TNFR2-mediated ... phosphatidylinositol 3-kinase ⁄ Akt pathway. Thereby, this cascade may lead to an autoregulatory loop, which could lead to a persistent protein kinase B ⁄ serine-threonine kin...

Ngày tải lên: 28/03/2014, 23:20