Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx

... family of proteins, suppressor of cytokine signaling (SOCS) proteins, is an importantnegative regulator for cytokine signaling [6,7].CIS /SOCS family: structure and actionmechanism SOCS and cytokine- inducible ... gp130, Tyr985 of the leptin receptor and Tyr401 of the erythropoietinreceptor, Tyr729 of the granulocyte colony-stimulating factor(G-CSF) receptor, Tyr800 of the IL-12 receptor and Tyr985 of the ... and activators of transcription 3) and suppressor of cytokine signaling 3 (SOCS3 ) in macrophages. SOCS3 stronglysuppresses STAT3 activated by IL-6/gp130 but not by IL-10, because SOCS3 does not...

Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf

... aim ofthis studywas tocharacterize the role of an acyl-CoA thioesterase (ARTISt) and an acyl-CoA synthetase as members of an alternativepathway in the regulation of the intracellular levels of ... cell-free assay[28,29]. The activity of the protein was dependent on cAMP and PKA and blocked by the use of 4-bromophenacyl-bromide (BPB) and NDGA, both inhibitors of AA release.Importantly, this ... (MTE-I) and peroxisomal forms (PTE-Ia and Ib) of the enzyme [35]. Recently, this gene family wascloned and characterized in mouse showing that all isoformsare encoded by three exons spaced by two...

Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot

... stress by redirect-ing t he synthetic machinery towards the synthesis of s omeenzymes involved in glycolysis or sugar-phosphatemetabolism [54].HydA belongs to a new class of Fe-hydrogenasesHydA ... they often catalyze the reduction of pr otons with a high speciﬁc activity to yield hydrogen[16]. Interestingly, Fe-hydrogenases were not found incyanobacteria, the free-living ancestor of ... Fe-hydrogenasesHydA of C. reinhardtii, the ﬁrst isolated gene encodinga hydrogenase of a photosynthetic eukaryotic cell, repre-sents a novel type of Fe-hydrogenases. Parts of thededuced amino-acid sequence of...

Báo cáo Y học: Transcriptional regulation of erythropoiesis Fine tuning of combinatorial multi-domain elements ppt

... differen-tiation in erythroid progenitors. Polycytemia vera is a clonalmyeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... regulatory elements of many erythroid genes [e.g.globins, band 3, EKLF, FOG, erythropoietin receptor(EpoR) and heme biosynthetic enzymes] [27,28].GATA-2, a member of the GATA family, is expressed ... expansion and survival of early hematopoietic cells, at the expense of differenti-ation.The proto-oncogene c-Mybc-Myb is abundantly expressed in immature hematopoieticcells of erythroid, myeloid and...

Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx

... morphology afterinduction of diﬀerentiation of HL-60 cells by dimethylsulfoxide and TPA. (A) HL-60 cellscultured in RPMI for 3 days (control for B),followed by cytospin analysis and staining(·1000). ... activity wasdramatically diminished. Alternatively, hTR and hTERTmay play a minimal catalytic activity in telomerase, whilethe assembly of other telomerase subunits may amplify theenzyme function. ... details.Fig. 3. Activation of telomerase activity by stimulating PBMC withPHA. (A) Relative telomerase activity on each day. (B) RNAexpression of telomerase subunits, analysed by RT-PCR and resolvedin...

Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt

... primar-ily by chondrocytes, by synovial fibroblasts and on occa-sion, by osteoclasts [7,10–12].The interstitial collagens (types I, II and III), are the princi-ple targets of destruction, and the ... connective tissue, and is usually produced only by cartilage and bone during development, and by chondro-cytes in osteoarthritis (OA) [6–8].Expression of MMPs is low in normal cells, and these lowlevels ... Brinck-erhoff CE: A synthetic triterpenoid selectively inhibits theinduction of matrix metalloproteinases 1 and 13 by inflamma-tory cytokines. Arthritis Rheum 2001, 44:1096-1104.64. Suh N, Wang Y, ...

Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis" ppsx

... bromide stained2% agarose gel by electrophoresis and visualized by ultravio-let light.Detection of autoantibodiesThe presence of RF was determined by laser nephelometryaccording to the manufactor's ... 1.The presence of erosive joint disease was evaluated by analyz-ing the previously available hand and feet radiographs of thepatients. The presence of extra-articular manifestations of thedisease ... by retrospective chart review and by anal-ysis of an available clinical database as described previously[24]. The following extra-articular manifestations of the dis-ease were documented by...

Báo cáo y học: " Transcriptional regulation of metastatic [Id]entity by KLF17" pdf

... of expression of KLF17 by transcriptional suppression or inactivation by post-translational modification (possibly by phosphorylation or dephosphorylation) leads to transcription of ID1 through ... high-stringency target site for phosphorylation by protein kinase C-ε (PKCε) within the amino-terminal region of KLF17. Given that the activity of some Sp1/KLF family members is known to be regulated by ... regulation of invasion and metastasis in different cancer types.Figure 1 Regulation of ID1 expression by KLF17. ID1 transcription is suppressed by KLF17 binding to the ID1 promoter. Loss of expression...

Báo cáo y học: "Differential regulation of diacylglycerol kinase isoform in human failing hearts" pps

... Japan.2Department of Cardiovascular, Thoracic, and Pediatric Surgery, Yamagata University School of Medicine, Yamagata, Japan.3Department of Cardiology and Hematology,Fukushima Medical University, Fukushima, ... expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independentpathways. Proc Natl Acad Sci USA 1998, 95:13893-13898.8. Takeishi Y, ... Ohta J,Tada H, Minatoya Y, Sakuma M, Watanabe J, Goto K, Shirato K, Kagaya Y: Differential regulation of diacylglycerol kinase isozymes in cardiachypertrophy. Biochem Biophys Res Commun 2005,...

Báo cáo y học: "A Comparison of Immuncapture Agglutination and ELISA Methods in Serological Diagnosis of Brucellosis"

... analyzed by using the paired t test method on SPSS for Windows 13.0 software. This study was approved by the local institutional ethics committee of the Selcuk University Meram Faculty of Medicine. ... similar study conducted by Memish et al., which included 68 patients with brucellosis and 70 control group, sensitivity and specificity were found to be 45.5 % and 97.1 % for Ig M and 79 % and 100 ... than one by one increases their sensitivity and specificity values. The Ig G and Ig M sensitivities found in our study were higher in comparison to the study in question but specificity is lower....

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