Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx

... family of proteins, suppressor of cytokine signaling (SOCS) proteins, is an important negative regulator for cytokine signaling [6,7]. CIS /SOCS family: structure and action mechanism SOCS and cytokine- inducible ... gp130, Tyr985 of the leptin receptor and Tyr401 of the erythropoietin receptor, Tyr729 of the granulocyte colony-stimulating factor (G-CSF) receptor,...

Ngày tải lên: 09/08/2014, 06:23

... aim ofthis studywas to characterize the role of an acyl-CoA thioesterase (ARTISt) and an acyl-CoA synthetase as members of an alternative pathway in the regulation of the intracellular levels of ... cell-free assay [28,29]. The activity of the protein was dependent on cAMP and PKA and blocked by the use of 4-bromophenacyl- bromide (BPB) and NDGA, both inhibitors of A...

Ngày tải lên: 08/03/2014, 09:20

... stress by redirect- ing t he synthetic machinery towards the synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA ... they often catalyze the reduction of pr otons with a high specific activity to yield hydrogen [16]. Interestingly, Fe-hydrogenases were not found in cyanobacteria, the free-living ances...

Ngày tải lên: 08/03/2014, 22:20

... differen- tiation in erythroid progenitors. Polycytemia vera is a clonal myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... regulatory elements of many erythroid genes [e.g. globins, band 3, EKLF, FOG, erythropoietin receptor (EpoR) and heme biosynthetic enzymes] [27,28]. GATA-2, a member of t...

Ngày tải lên: 08/03/2014, 22:20

... morphology after induction of differentiation of HL-60 cells by dimethylsulfoxide and TPA. (A) HL-60 cells cultured in RPMI for 3 days (control for B), followed by cytospin analysis and staining (·1000). ... activity was dramatically diminished. Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may...

Ngày tải lên: 17/03/2014, 23:20

... primar- ily by chondrocytes, by synovial fibroblasts and on occa- sion, by osteoclasts [7,10–12]. The interstitial collagens (types I, II and III), are the princi- ple targets of destruction, and the ... connective tissue, and is usually produced only by cartilage and bone during development, and by chondro- cytes in osteoarthritis (OA) [6–8]. Expression of MMPs is l...

Ngày tải lên: 09/08/2014, 03:24

... bromide stained 2% agarose gel by electrophoresis and visualized by ultravio- let light. Detection of autoantibodies The presence of RF was determined by laser nephelometry according to the manufactor's ... 1. The presence of erosive joint disease was evaluated by analyz- ing the previously available hand and feet radiographs of the patients. The presence of extra-a...

Ngày tải lên: 09/08/2014, 14:21

... of expression of KLF17 by transcriptional suppression or inactivation by post-translational modification (possibly by phosphorylation or dephosphorylation) leads to transcription of ID1 through ... high-stringency target site for phosphorylation by protein kinase C-ε (PKCε) within the amino-terminal region of KLF17. Given that the activity of some Sp1/KLF family members i...

Ngày tải lên: 09/08/2014, 20:20

... Japan. 2 Department of Cardiovascular, Thoracic, and Pediatric Surgery, Yamagata University School of Medicine, Yamagata, Japan. 3 Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, ... expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sc...

Ngày tải lên: 10/08/2014, 09:21

... analyzed by using the paired t test method on SPSS for Windows 13.0 software. This study was approved by the local institutional ethics committee of the Selcuk University Meram Faculty of Medicine. ... similar study conducted by Memish et al., which included 68 patients with brucellosis and 70 control group, sensitivity and specificity were found to be 45.5 % and 97.1 %...

Ngày tải lên: 25/10/2012, 10:56