Báo cáo y học: " Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes" ppsx

... expression in bovine and human OA chondrocytes. Mithramycin dose-dependently diminished these inductions. TNF-α-induced MMP gene expression is inhibited by mithramycin TNF-α is another prominent inflammatory ... online http://arthritis-research.com/content/7/4/R777 R777 Vol 7 No 4 Research article Mithramycin downregulates proinflammatory cytokine-induced matrix metallo...

Ngày tải lên: 09/08/2014, 06:22

... receptor editing in systemic lupus erythemato- sus. J Clin Invest 1998, 102:688-694. 35. Dörner T, Farner NL, Lipsky PE: Immunoglobulin lambda and heavy chain gene usage in early untreated systemic ... been characterized in detail, but the cytokines involved in local B cell activation remain largely unknown. Chemokines The infiltration of lymphocytes into glandular aggregates appare...

Ngày tải lên: 09/08/2014, 01:21

... Chang DM, Lai JH, Tai TY: Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK- AP-1 signaling in human chondrocytes. Biochem Pharmacol 2005, ... only ATRA inhibited IL-1-induced IL-6 expression in rat synovial fibroblasts by inhibiting ERK 1/2 pathway and subsequent activation of AP-1 and NF-IL-6 independently of RAR....

Ngày tải lên: 09/08/2014, 01:22

... replication study had not been performed. Conclusion Our study illustrates the necessity to include a large number of patients in genetic case-control studies. In fact, sampling bias may partly account ... study was supported by Réseau de recherche clinique INSERM. References 1. Kristiansen OP, Larsen ZM, Pociot F: CTLA-4 in autoimmune dis- eases – a general susceptibility gene to aut...

Ngày tải lên: 09/08/2014, 10:20

... article Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1β stimulated fibroblast-like synoviocytes Kyoung Soo Kim 1 , Eun Kyung Park 1 , Seung Min ... chloramine (TauCl). Notably, TauCl has been shown to play a major role in downregulating the expression of inflammatory mediators such as chemokines, cytokines, cyclo- oxygenase-2...

Ngày tải lên: 09/08/2014, 10:20

... splenocytes. In arthritic mice, TIARP mRNA was expressed mainly in CD11b + cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied by joint swelling), especially in hyperplastic ... adipose-related protein (TIARP) was specifically and strongly induced in splenocytes. Gene- Chip analysis was performed by gene expression software. ADAM17, a disint...

Ngày tải lên: 09/08/2014, 14:22

... phylogenetics. In Extinction and Phylogeny. Edited by Novacek MD, Wheeler QD. New York: Columbia University Press; 1992:205-215. 12. Gatesy J, Milinkovitch M, Waddell V, Stanhope M: Stability ... mammal genomes in the gene trees increases the probability of finding a gene misplaced in the tree.’ We had anticipated that possibility in our study (page 6, second paragraph in Mili...

Ngày tải lên: 09/08/2014, 22:23

... ventricle a congenital cardiomyopathy, which is characterized by hypertrabe- culations and deep recesses in the ventricular wall led by a defect in morphogenesis during embryogenesis [1]. ILVNC is a ... contributions AC, YO and TC analyzed and interpreted the patient data. TB, HB and ST were involved in doing the literature review and manuscript preparation and MA was also instrumental...

Ngày tải lên: 10/08/2014, 09:22

... specifically and efficiently inhibit either ÔunwantedÕ proteins or viral RNA gene expression via catalytic hydrolysis of specific internu- cleotide bonds of the target RNA. The functional activity of endogenously ... which is an aspartyl protease Asp2, also called BACE protein or memapsin 2 [9–13]. This protein is involved in proteolytic cleavage of an amyloid precursor protein APP, and di...

Ngày tải lên: 08/03/2014, 08:20