Báo cáo y học: "Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin" pptx
Báo cáo y học: "Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin" pptx
... fromthat of other early inflammatory arthritides and of establishedRA. The nature of the cytokines present in the synovial fluid of patients with early RA suggests that this response is likely toinfluence ... earlyinflammatory arthritis who subsequently developed RA had a distinct but transient synovial fluid cytokine profile. The levels of a range of T cell, macrophage and stromal cell related cytokines(e.g. ... fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest thatgamma-interferon is not the primary macrophage activatingfactor. Arthritis...
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Báo cáo y học: "Collagen-induced arthritis is exacerbated in IL-10-deficient mice" pps
... play a dual role indisease activity. Anti-IFN-γ treatment early in the course of disease suppresses arthritis, whereas neutralization of IFN-γ late in disease exacerbates arthritis. In addition,IFN-γ ... to rheumatoid arthritis. Keywords: antibody, arthritis, autoimmunity, cytokinesOpen AccessAlthough CIA is considered a Th1-type disease mediated by IFN-γ, the role of IFN-γ in the pathogenesis ... Clinical features and histopathology. Arthritis Rheum 1987, 30:201.28. Finnegan A, Needleman B, Hodes RJ: Activation of B cells by autoreactive T cells: cloned autoreactive T cells activate Bcells...
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Báo cáo y học: "Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes" ppt
... was gen-erated with 5'-GTTATTGCCTATTCCTATTATG-3' and 5'-GTCCATCATGAAGGGTGGAAA-3'. The MMP-1 PCR prod-uct was generated with 5'-CTGAAGGTGATGAAGCAGCC-3' and 5'-AGTCCAAGAGAATGGCCGAG-3'. ... 4Immunohistochemical analysis of activation markers in synovial membranes of rheumatoid arthritisImmunohistochemical analysis of activation markers in synovial membranes of rheumatoid arthritis. ... inflammatory disease of unknown aetiology and is characterised by hyperplasia and chronic inflammation of the synovial membranes that invadedeeply into the articular cartilage and bone. Activated...
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Báo cáo y học: "Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies" ppt
... L, DanisitTIRA Group: Connective tissue metabolism in patients withunclassified polyarthritis and early rheumatoid arthritis. Rela-tionship to disease activity, bone mineral density, and radio-graphic ... MMP-1: TIMP-1 ratio in rheumatoid arthritis synovial explant culturesIL-1 7A significantly shifts the MMP-1: TIMP-1 ratio in rheumatoid arthritis synovial explant cultures. Whole rheumatoid arthritis ... shown that IL-1 7A is highly expressed inthe inflammatory joint and drives disease activity, implicating itas a key cytokine and potential therapeutic target. We haveshown that IL-1 7A not only...
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Báo cáo y học: "Early innate immune events induced by prolonged cold ischemia exacerbate allograft vasculopathy" potx
... R,Kucheryavaya AY, Rahmel AO, Hertz MI: Registry of the InternationalSociety for Heart and Lung Transplantation: Twenty-sixth official adultheart transplant report-2009. J Heart Lung Transplant 2009, ... DD, Argenziano M,Stewart AS, Oz MC, Naka Y: The effect of ischemic time on survival afterheart transplantation varies by donor age: An analysis of the UnitedDevitt et al. Journal of Cardiothoracic ... car-diac t ransplants has no t improved in the last threedecades and still hovers at approximately 50% in mostcentres [1]. The primary manifestation of late graftrejection in cardiac transplants...
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Báo cáo y học: "Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis" pdf
... informa-tion was obtained by review of follow-up visits and by stand-ardized telephone interviews. Statistical analysis was done by χ2 test and linear multiple discriminant analysis for categorialdata ... naproxendosage and use of comedications are mostly a consequence of increased disease activity. As indicated in the present studyJIA disease activity, as indicated by laboratory parameters of inflammation ... 64% had the early-onset pau-ciarticular (EOPA) subtype of JIA, 16% had enthesitis-related arthritis, 9% had polyarthritis, 4% had chronic recurrent multi-focal osteomyelitis, 2% had systemic...
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Báo cáo y học: "Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia" pot
... full access to all of the study data and takes responsi-bility for the integrity of the data and the accuracy of the dataanalysis. He helped conceive of the study and participated inits design ... RA stage might help to choose the mostappropriate treatment.Introduction Rheumatoid arthritis (RA) is a chronic, autoimmune, and inflammatory polyarthritis that induces joint damage and disa-bility. ... 'algorithm 2'option (that is, spot morphology is the critical parameter), and every spot within an array was quantitated with the 'weightedmean intensity' option (that is, the average...
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Báo cáo y học: "Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study" potx
... M, Emery P, Feldmann M, etal.: Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. ... show any manifestation potentially related to a full-blown lupus disease. Accordingly, IgG anti-dsDNAautoantibodies seemed to be at low titers and to display lowaffinity, as demonstrated by their ... thestudy. The group of patients treated with methotrexate alonedisplayed a stable disease activity during the study with no sig-nificant changes in all the clinical assessment parameters(data not...
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Báo cáo y học: "Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis" pdf
... degra-dative phase of apoptosis through the activation of caspases3 and 7 [23]. An additional pathway of death receptor-induced cell death may proceed through the mitochondrial pathway by activating ... numbers areassociated with articular destruction in RA patients [2,3] and these macrophages are highly activated and contributedirectly to synovial inflammation and destruction of cartilage and ... of inflammatory arthritis [27,28]. These data suggest that a syn-ergy between the extrinsic and intrinsic apoptotic pathwaysmay be required to prevent or reduce the development of inflammatory arthritis. ...
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Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
... activation of Toll-likereceptors.The therapeutic profile of CIA in the B6 mouse was similar tothat of RA, with a therapeutic action of methotrexate at a dosecomparable to human therapy. This ... vehicle alone. Each experiment was performed twice.Statistical analysisStatistical analysis was performed by one-way analysis of var-iance followed by Dunnett multiple comparisons test, whereappropriate.ResultsInduction ... 30:1568-1575.12. Kai H, Shibuya K, Wang Y, Kameta H, Kameyama T, Tahara-Hanaoka S, Miyamoto A, Honda S, Matsumoto I, Koyama A, et al.:Critical role of M. tuberculosis for dendritic cell maturation toinduce...
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