Báo cáo y học: "Natural killer T cells and rheumatoid arthritis: friend or foe" ppt

... communication network that results in TGF-β1 secretion is only partially understood. Kim et al., propose that Vαi NKT cells suppress the production of TGF-β1 by synovial cells through the production ... the precise mechanism(s) by which Vαi NKT cells are attracted to synovial tissue and the reason(s) why they get activated locally in the K/BXN serum transfer model to induce TGF-β1 hav...

Ngày tải lên: 09/08/2014, 06:22

... as to how ASD and testosterone are able to inhibit these two important proinflammatory enzyme pathways in synovial cells of RA and OA patients. Competing interests The author(s) declare that they ... gender and therapy. These stimulated, cen- tral enzyme pathways can be inhibited by administration of the two androgens ASD and testosterone. This study provides a further rationale to...

Ngày tải lên: 09/08/2014, 06:23

... long-term tobacco histories. Third, as we learn to subtype RA, it would be important to look at the relationship between anti-cyclic citrullinated peptide antibody status and malignancy. Is the ... Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: system- atic re...

Ngày tải lên: 09/08/2014, 10:23

... activation receptors, allowing them to respond to ligands on potential target cells [17–20]. The ligands for activation receptors are often closely related to the ligands for inhibitory receptors. ... ability to lyse tumor cells without prior sensitization, more recent work has demonstrated that they have a crucial role in the initial defense against pathogens and are particularly impor...

Ngày tải lên: 09/08/2014, 01:23

... production, indicating a potential role for regulatory T cells to influence the inflammatory processes in the joint. These features were apparent in the vast majority of the patients despite the different treatments ... patients with JIA it has been reported that T cells in synovial fluid are not in active cell cycle [28]. This study is the first to demonstrate that CD25 bright CD4 +...

Ngày tải lên: 09/08/2014, 01:23

... cytolytic activity in patients with juvenile rheumatoid arthritis (JRA)NK cell cytolytic activity in patients with juvenile rheumatoid arthritis (JRA). Activity of NK cells was determined after ... NK cytolytic activity and perforin/ granzyme B expression between the patient and control groups. The rank correlation test was used to characterize the relationship between NK cell acti...

Ngày tải lên: 09/08/2014, 06:22

... These observations provide qualitative support to the quantitative studies on inflammatory cells obtained from SRT by enzymatic digestion (Figure 3c). Importantly, they show that Mϕ are a numerically small ... [12,43], there- fore, may result from the encounter between autoreactive effector T cells and immature DCs and these cells may exac- erbate disease by permitting recursive c...

Ngày tải lên: 09/08/2014, 10:22

... populations with more limited capacity for differentiation; specifically, monopo- tent or bipotent cells may have differentiation potentials developmentally adapted to (and perhaps restricted to) the ... undiffer- entiated cells. Constitutive expression of cytokines, such as granulocyte-colony stimulating factor, stem cell factor, leukemia inhibitory factor, macrophage-colony stimulatin...

Ngày tải lên: 09/08/2014, 01:21

... were among the genes that best correlated with laboratory indices. The gene that exhibited the strongest correlation with total white cell, and total and percentage neutrophil counts was Versican, ... follows: forward, 5'-CGCCTAAGACACTACGTATGCTTGT-3'; reverse, 5'- TTGGTCCTATGTTGACTGTTTCTCA-3'; and probe, 5'- AGCATAGTCATTCCCTCTAAGCCAAAGAAGGTTC-3', labeled wi...

Ngày tải lên: 09/08/2014, 07:20

... that combination treatment does better than monotherapy. However, patients stabilized on combination treatment might do worse if shifted to monotherapy, and patients refractory to monotherapy could ... interpreted the results and wrote the first draft, and commented on following drafts. XG contributed to the interpretation of results, wrote subsequent drafts. EV contributed to the liter...

Ngày tải lên: 09/08/2014, 01:21