Báo cáo y học: "Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption" ppt

... collagenases, and Figure 1 Histone deacetylase inhibitors block cartilage glycosaminoglycan and collagen loss induced by IL-1α/OSMHistone deacetylase inhibitors block cartilage glycosaminoglycan and collagen ... 3 Histone deacetylase inhibitors abrogate IL-1α/OSM-induced expression of key metalloproteinase genesHistone deacetylase inhibitors abrogate IL-1α/O...

Ngày tải lên: 09/08/2014, 06:22

... G: Binding mode analysis of 3-(4-benzoyl-1- methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and ... 3-(4- toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propena- mide; ( MS-275): [N-(2-aminophenyl)-4-[N-(pyridine-3- ylmethoxy-carbonyl)aminomethyl]benzamide]; (PDTC): ammo nium pyrrolidinedithioc...

Ngày tải lên: 11/08/2014, 08:22

... allogeneic chondrocytes were transduced with equine insulin-like growth factor-1 or human bone morphogenetic protein (BMP)-7, incorporated into a fibrin clot, and implanted into surgically created, ... http://arthritis-research.com/content/7/6/273 Abstract The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics was held in Boston, Massachusetts, USA in May...

Ngày tải lên: 09/08/2014, 07:20

... activity in SKOV3 cells. In our EMSA analyses, aside from the shifted band that contained USF1 and USF2, we observed other shifted bands (X and Y) . As bands X and Y were only partially inhibited by ... protein tyrosine phosphatases, SHP-1 and SHP-2 are distinguished by the presence of two tandem src-homology 2 domains. Src- homology 2 domains interact with phospho-tyrosine res...

Ngày tải lên: 08/03/2014, 23:20

... Q-PCR using RA and OA synovia To determine whether the Q-PCR technique can detect differences in cytokine gene expression in OA and RA synovia, nine RA and 13 OA synovial tissues were sampled and ... standard generated with activated PBMC cDNA significantly improves assay reliability by reducing variation and by simplifying assay development. Analysis of RA synovia indicates...

Ngày tải lên: 09/08/2014, 01:23

... model in which mAb C11C1 inhibited inflammatory changes in joints, systemic inflammation, and activation of the kallikrein–kinin system [20]. Here we have demonstrated its efficiency in treat- ing ... Pixley RA, Li F, Sainz I, Sartor RB, Adam A, Colman RW: Kininogen deficiency modulates chronic intestinal inflam- mation in genetically susceptible rats. Am J Physiol Gastroin- test Li...

Ngày tải lên: 09/08/2014, 06:22

... inhibitor Apolipoprotein A α 1 -Antitrypsin PEDF Fibronectin Tetranectin Fibronectin Clustrin H 4 inhibitor α 1 -Antichymotrypsin Pregnancy zone protein Gelsolin α 1 -Acid glycoprotein Fibrinogen S100 Kinninogen ... binding protein A9 (calgranulin B) 50363217 Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (NP_000286) 50363221 Serine (or c...

Ngày tải lên: 09/08/2014, 10:20

... 1 Inhibition of hyaluronan export in bovine chondrocytesInhibition of hyaluronan export in bovine chondrocytes. (a) Cartilage explants were incubated in the absence and presence of IL-1α and ... by about sixfold, and the inhibitors partially reversed it. In control experiments, the inhibitors were analyzed for their effect on the hyaluronan synthase activity of chondroc...

Ngày tải lên: 09/08/2014, 10:22

... anti-apoptotic proteins, including Mcl-1, Bcl-2, and Bcl-x >L , were determined in rabbit osteoclasts and in cytokine-starved mouse osteoclasts by Western blotting. Results RANKL significantly attenuated ... expressed in cells of the myeloid lineage such as macrophages and neutrophils [34,35], and is also known to be increased in synovial macro- phages and fibroblasts in...

Ngày tải lên: 09/08/2014, 14:20

... directly by affecting its DNA-binding affinity or inter- action with accessory proteins at the promoter. Alternatively, or in addition, protein-lipid/sterol binding may positively or negatively affect ... proteins differ in plants and animals A subset of animal and plant START proteins contain an amino-terminal PH domain, which is found in a wide variety of eukaryotic proteins impli...

Ngày tải lên: 09/08/2014, 20:20