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Báo cáo y học: "The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products" potx

Báo cáo y học:

Báo cáo y học: "The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products" potx

... 3Research articleThe P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic productsJames I Elliott, John H McVey and ... PS and associatedproteins are major targets of autoantibodies in SLE [8],cells stimulated via the P2X7 receptor may be a significantsource of autoantigen in this disease.An allelic variation ... P2X7, an initiator of a form of programmed cell deathknown as aponecrosis, is a candidate product of murine and human lupus susceptibility loci. One such locus in (NZB ×NZW)F1 mice is lbw3,...
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Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt

Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt

... GPVI was functional, we measuredtyrosine phosphorylation of the FcR c-chain and thetyrosine kinase Syk, which is tyrosine phosphorylated and activated early after GPVI engagement. Phosphorylation ... c-chain in COS-7 and K562 cells, and that the transmembrane arginine and cytoplasmicdomain of GPVI are necessary for association with the FcRc-chain. Moreover, the FcR c-chain is necessary and sufficient ... in platelets and megakaryocytes. Itbelongs to the superfamily of immunoblobulin receptors and is closely related to Fca receptor (FcaR) and naturalkiller receptor [1]. The cloned cDNA of GPVI...
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Báo cáo y học:

Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx

... Janwityanujit11Division of Allergy, Immunology and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Bangkok10400, Thailand2Research ... genotype and clinical manifestation or laboratoryprofiles of SLE also cannot be statistically demonstrated. Inconclusion, we cannot verify any association between VDRgene BsmI polymorphism and ... Although Asians are closely related ethnically,the genetic admixture in Japan or China is different from that of Thailand. Because a high prevalence and high clinical sever-ity of SLE are also...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt

Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt

... Instrumental Analysis, Niigata University, JapanBinding of lamin B receptor (LBR) to chromatin was studie dby means o f an in vitro assay system involving recombinantfragments of human LBR and Xenopus ... Biochemistry, Faculty of Science, Niigata University, Japan;4Laboratory of Applied Molecular Biology, Department of Applied Biochemistry, University of Osaka Prefecture, Osaka, Japan;5Center ... treated proteins w ere extracted with SDS and then analyzed bySDS/PAGE, followed by CBB staining and autoradiography. Lanes 1 and 4 , GST; lanes 2 and 5, GST–NK; l anes 3 and 6, GST– RS.The arrowhead...
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Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf

Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf

... containing NBD2 is mutated in persistent hyperinsulinaemic hypoglycaemia of infancy. The disease is autosomal recessive and is characterized by profound neonatal hypoglycaemia and inappropriate ... 28079–28082.34. Matsuoka, T., Matsushita, K., Katayama, Y. , Fujita, A. ,Inageda, K., Tanemoto, M., Inanobe, A. , Yamashita, S.,Matsuzawa, Y. & Kurachi, Y. (2000) C-terminal tails of sulfo-nylurea receptors ... hyperinsulinaemichypoglycaemia of infancy is an hereditary disease char-acterized by inappropriately high levels of insulin release and hypoglycaemia in children at birth. It is hypothesizedthat deletion of the...
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Báo cáo y học:

Báo cáo y học: "The role of the purinergic P2X7 receptor in inflammation" pot

... inDiagrammatic representation of the interplay between inflammatory mediators and cellsFigure 3Diagrammatic representation of the interplay between inflammatory mediators and cells. Tissue damage ... the production of the pro-inflamma-tory cytokines IL-1β and IL-18, and potentially the innateimmune response, was recently and beautifully describedby Mariathasan and colleagues [47]. These authorsshowed ... resolution of inflammatoryprocesses [95]. Apoptosis is regulated at a cellular level bythe expression and activation of the Bcl-2 family of pro-teins and the components of the caspase pathways, whichdictate...
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Báo cáo y học:

Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"

... positively skewed; therefore, they were transformed logarithmically to approximate normal distribution, and such data were analysed statistically. Statistical analysis of the data analysis was carried ... Mukawa H, Tomida T, Suzuki T, Kamiya H, Matsui H, Hayakawa T. Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary ... primer (5'-TGAAGGAGAAGGTGTCTGCGGGA-3' and 5'-AGGACGGTGCGGTGAGAGTG-3'). PCR was performed in a GeneAmp, thermocycler (Biorad, USA), and the profile consisted of an initial melting...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf

Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf

... and is predominantly linear. Potatoarabinogalactan consists of 86%D-galactose and 6.6%L-arabinose, while soy arabinogalactan consists of 57%D-galactose and 38%L-arabinose. Methylation analysisdemonstrated ... duplicate.The hydrolysis activity of GALA with different arabino-galactans was measured in duplicate by HPAEC and MALDI-TOF MS after incubation of 1 mgÆmL)1 of potato, onion and soy arabinogalactan ... with a) 1-,3-linkedL-arabinofuranose chains.Type I arabinogalactan is degraded by b-1,4-endogalacta-nase and b-galactosidase. b-1,4-Endogalactanases cleavewithin the galactan moiety of type...
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Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx

Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx

... n and chromato graphy was perfo rmed as describe d inMaterials a nd methods. Enzyme activity was a nalysed by the standardassay and the i mmunoreactivity was detected by Western blot analysis and ... variants of TPP II ( i.e. rat,mouse, fruit y, Arabidopsis thaliana, Caenorhabdit is elegans and Schizosaccharo myces pombe), and at least three human EST-clones covering this area (GenBank a ... the Asp and His of thecatalytic triad. M ost other subtilases h ave about 20 aminoacids in this region and the large in sertion is a specialfeature of TPP II and pyrolysin [9,21]. There are,...
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