Báo cáo y học: "Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity" pdf

... 3 Research article Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity Karin Lundberg 1 , Suzanne ... citrullinated proteins and the enzyme PAD4 are correlated with severity of inflammation and are not detect- able in healthy joints. The study also reveals tha...

Ngày tải lên: 09/08/2014, 06:22

... [7,27]. Unfortunately, the increased presence of citrullinated proteins was not investigated in that study. Some studies dealing with the second possibility have recently been published. Masson-Bèssiere and ... PAD4 mRNA stability. In theory, this could result in more PAD4 enzyme being produced and subsequently lead to increased citrullination of proteins and a highe...

Ngày tải lên: 09/08/2014, 01:23

... MREa-binding activity, which consisted of two polypeptides of approximately 70 and 82 kDa. N-terminal and internal amino acid sequencing and immuno analyses revealed that MREa-binding proteins ... consistent with previous studies showing that the Ku-70 protein interacts with DNA without requiring Ku-80 [50]. Using the avidin–biotin system, we purified two MREa- binding proteins f...

Ngày tải lên: 17/03/2014, 23:20

... process with coding analysis and data collection occurring simultaneously and informing both the evolving inter- view guide and coding dictionary [25-27]. After con- ducting the first set of interviews, ... following instruction appears to be ingrained in their reasoning for bringing in the letter. These indivi- dualsstatedtheyweresimplydoingwhattheletter requested of them. ‘For...

Ngày tải lên: 11/08/2014, 05:21

... non-enzymatic pathway Int. J. Med. Sci. 2009, 6 http://www.medsci.org 367 lumination. Localizing the KRED protein to mito- chondria resulted in an increased cytotoxic efficiency with the ... KRED protein Figure 5 Physical map of the vector expressing the fusion protein KRED-Lamin B1. The Lamin B1 was inserted into the MCS. (The Lamin B1 sequence was kindly provided by Harald...

Ngày tải lên: 26/10/2012, 09:48

... phosphorylated by a Tob- associating kinase [41] and that cyclin-dependent kinase inhibitors, functioning at the G1 and G1/S phases, are degraded by the ubiquitin-proteasome system in a phos- phorylation-dependent ... regulatory proteins and abnormal proteins [32–35]. In this system, target proteins are first tagged with multiubiquitin chains via isopeptide bonds, catalyzed b...

Ngày tải lên: 31/03/2014, 21:21

... online in July 2004 and in print in October of the same year, it is referred to by most as the GOALtrial (from the now familiar acronym for “Gaining Optimal Asthma controL”). Based on what we have ... using inhalers containing combined salmeterol and fluticasone propionate. 2 The data were reanalyzed with a new endpoint based on a composite measurement of asthma control as defin...

Ngày tải lên: 08/08/2014, 20:23

... proteins and immunoglobulins in women with/ without connective tissue disease and with/ without silicone implantsSerum proteins and immunoglobulins in women with/ without connective tissue disease and ... serum protein profile in silicone implants subjects in the literature, Figure 2 Serum proteins and immunoglobulins in women with connective tissue disease...

Ngày tải lên: 09/08/2014, 10:21

... contributions and new directions of the field. Dynamic proteins and complexes Beyond the beautiful static structures that we see using crystallography, proteins are inherently dynamic, and many sample ... While dynamics are vital to the function of virtually all proteins, a major goal is to understand the dynamics of two types of proteins that have critical roles in many...

Ngày tải lên: 09/08/2014, 20:20

... drafting, revising, and final approval of the manuscript. SS was involved in the study conception and design, data analysis, and in the revising and final approval of the manuscript. Competing interests TS ... practices. Secondly, densely populated areas in Norway have been found to have better educated and more experienced ambulance personnel providing patient care [26]....

Ngày tải lên: 25/10/2012, 09:56