Báo cáo y học: "Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblast" pot
Báo cáo y học: "Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblast" pot
... article Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts Shingo Nakayamada 1 , Hitoshi Kurose 2 , Kazuyoshi Saito 1 , Akira Mogami 3 and Yoshiya ... growth of synovial cells. Introduction Rheumatoid arthritis (RA) is characterized by synovial pro- liferation, neovascularization, and accumulation of inflam-...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Small variable segments constitute a major type of diversity of bacterial genomes at the species level" pptx
... proportionally. Discussion Microdiversity constitutes a m ajor type of variability between bacterial genomes within a species Themainoutcomeofthisstudyisthediscoveryofa major type of bacterial ... ana- lyses offer the possibility to examine genome diversity globally, but most studies usually concentrate on just a single class of VSs. One exception involves a systematic analysis of all...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... for different leuko- cyte subsets. A hypothetical framework for migration of leukocytes and lymphocytes in tissues is provided by the multistage guid- ance of leukocytes by chemokines and bacterial ... anti-inflammatory drug oxaceprol reduced leukocyte adherence to synovial microvessels and gener- ally reduced the signs of inflammation. The groundwork for further studies on the dynami...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis" pps
... for assay of rheumatoid synoviocyte chemotaxis. Clin Exp Rheumatol 1994, 12:293-299. 28. al-Mughales J, Blyth TH, Hunter JA, Wilkinson PC: The chemoat- tractant activity of rheumatoid synovial ... migration of p21 (-/-) fibroblast-like synoviocytes (FLS) to rheumatoid arthritis (RA) synovial fluid (SF) is independent of cell cycle regulationEnhanced migration of p21 (-/-)...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx
... Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, Denmark; 2 Laboratory of Molecular Cardiology, Copenhagen University Hospital, University of Copenhagen, Copenhagen, ... study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G -protein coupling of the 7TM)7TM moiety is mediated by another mecha...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx
... cleavage assay should be reflected by inhibition of the reaction catalysed by htopo I rather than by inhibition of the movement of the enzyme between DNA substrate molecules. Elimination of a dissociation ... unphosphorylated within its SR motif recognized by htopo I [13]. To investigate the effect of phosphorylation of SF2/ASF, we used SF2/ASF previously phosphorylated by htopo I....
Ngày tải lên: 24/03/2014, 03:21
Báo cáo Y học: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression pdf
... Brygida Berse 1 1 Department of Pathology and Laboratory Medicine and 2 Department of Psychiatry, Boston University School of Medicine; Boston, MA, USA The expression of t he c holine acetyltransferase ... acetyl coenzyme A is catalyzed by the enzyme choline acetyltransferase (ChAT, acetyl-CoA:cho- line O-acetylotransfe rase, EC 2.3.1.6) [1]. Following syn- thesis, ACh is transported...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo Y học: LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1 docx
... the same protein produced by processing of mLRP130. Subcellular localization of mLRP130 was analyzed by immunofluorescence microscopy and cell fractionation analysis. The localization of mLRP130 ... aliquot of eluate was used for electrophoretic mobility shift assay. Electrophoretic mobility shift assay (EMSA) DNA-binding activities of mLRP130 were analyzed by EMSA as described pre...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells" pdf
... over-expressionComparison of the phenotypic profiles of DCLCs primed with or without IFIT4 over-expression. (a) Surface antigens of normal THP-1 cells were examined by flow cytometry. (b) To analyze the effect of ... signatures in sys- temic lupus erythematosus blood. J Exp Med 2003, 197:711-723. 32. Han GM, Chen SL, Shen N, Ye S, Bao CD, Gu YY: Analysis of gene expression profiles...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is ne" pdf
... Kelly TE, Saulsbury FT, Chance PF, Ochs HD: The immune dysregulation, polyendocrinopathy, enteropathy, X- linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001, 27:20. 17. You ... marked by red arrows) is highly expressed in synovial lining membranes in the inflamed joints of JIA patients. (b) HSP60 is released by the synovial tissues in the inflamed joint. In the sy...
Ngày tải lên: 09/08/2014, 14:20