Báo cáo y học: "The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthrits" pps
Báo cáo y học: "The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthrits" pps
... articleThe utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritisJames C Keith Jr1, Leo M Albert1, Yelena ... effect of treatment with WAY-169916 on inflammatory gene expression in FLS induced by TNF-αInhibitory effect of treatment with WAY-169916 on inflammatory gene expression in FLS induced by TNF-α. ... while retain-ing the anti-inflammatory activity as demonstrated here.The anti-inflammatory activity of WAY-169916 was furtherdemonstrated in a series of gene-profiling experiments. In the spleens...
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Báo cáo y học: " The utility of MRI in predicting radiographic erosions in the metatarsophalangeal joints of the rheumatoid foot: a prospective longitudinal cohort study" pdf
... diseaseduration of up to 5 years. A study by McQueen and colleagues[13] demonstrated that the highest rates of erosive activity may occur within the first year of disease. Although there wereonly five ... scoring wasbased on the percentage of involvement of the remainingbone.Synovitis was defined as synovial enhancement that appearedthicker than the width of the joint capsule after the administra-tion ... Therapy Vol 11 No 3 Mundwiler et al.Page 6 of 10(page number not for citation purposes)finding of interest is taken into account. Synovitis was the mostcommon finding in the study and was often...
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Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot
... mechanisms implicating viruses in theetiology of these diseases have been proposed [13]. Anintriguing aspect of autoimmune targeting of the RNAimachinery is that RNAi was initially recognized as ... surprising that the components of the RNAi machinery develop into targets of autoimmunity. On the one hand, the induction of apoptosisas a result of the infection may lead to molecular modification of ... complexes that are involved in the synthesis, processing and degradation of various classes of RNA targeted by the immune system in systemic autoimmune diseases? One explanation might be that under...
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Báo cáo y học: "The clinical utility of molecular diagnostic testing for primary immune deficiency disorders: a case based review" doc
... management including diagnosis, family studies, prognostic information, prenatal diagnosis and is useful in defining new diseases. In this review we outline the clinical utility of molecular testing ... the majority of X chromosomes bearing the wildtype allele are inactivated purely by chance. Females maymanifest X-linked disorders in this situation. More rarely,skewed lyonisation may be a consequence ... of a female with an XLP phenotyperaised concern that other female carriers including themother (IV:1) were at risk of symptomatic XLP in thiskindred. Analysis of the methylation patterns of...
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Báo cáo y học: "The PI3K–NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis" pdf
... the family of the Gi-protein-associatedcell membrane receptors. Receptor activation leads to inhibi-tion of adenylyl cyclase activity, inhibition of cAMP formationand inhibition of PKA expression, ... mediating the anti-inflammatoryeffect of adenosine. The highly selective A3AR agonist 1-deoxy-1-(6-{[(3-iodophenyl)methyl]amino}-9H-purine-9-yl)-N-methyl-β-d-ribofuranuronamide (IB-MECA) inhibited ... wart-mannin resulted in apoptosis of synoviocytes and macro-phages in rheumatoid arthritis [33]. Similarly, our findingsdemonstrating PKB/Akt inhibition followed by an increase in caspase-3 level in...
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Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway" ppt
... significantly increased during CIA development.Figure 3Induction of Synoviolin (SYN) expression by proinflammatory cytokinesInduction of Synoviolin (SYN) expression by proinflammatory cytokines. ... reports [33]. Intriguingly, only Erk activation is involved in SYN transcription, as indicated by the finding that the specificinhibitors against Erk, but not JNK and p38, block SYN expres-sion. ... byHampton and co-workers [6] as an E3 ubiquitin ligase in yeast.SYN is a multispanning membrane protein with its C-terminalRING (really interesting new gene) finger domain located in the cytoplasm...
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Báo cáo y học: "The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein" doc
... Huseyinov A, Hatip FB, Cinar MG, Evinc A: Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dualinhibitor of cyclooxygenase ... modify FLAP expression.These results indicate that the balance of PGE2 levels in OAosteoblasts is actually driving the expression of LTs, and con-versely that chronic inhibition of COX may ... which is reminiscent of the fact that PGE2inhibits 5-LO activity [55].We showed previously that in OA subchondral osteoblastslong-term treatment with NS-398, a selective COX-2 inhibitor,leads...
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Báo cáo y học: " Clinical utility of tibial motor and sensory nerve conduction studies with motor recording from the flexor hallucis brevis: a methodological and reliability study" pptx
... calcaneal branches of the tibial nerve[2,6,12]. Clinical presentation of posterior tarsal tunnelsyndrome often includes burning in the sole of the footand may include pain in the inferior calcaneus. ... exercised in interpreting appropriate statistical relia-bility. In other words, given the low temporal variability of these measure s, we can be confident in identifyingdifferences in these ... established with recording from the abductorhallucis. This technique is often technically challenging and clinicians have difficulty interpreting the informationparticularly in the short segment...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... mediated by in hibition of two steps in the NFB pathway by modifying specific cysteine residues in IKKaand in the p50-subunit resulting in the inhibition of nuclear translocation and DNA-binding ... observed inhibition of p50-binding to its DNAtargets by the reactive tellurium compound. II. At 4 h inhibit ion of iNOS expression by AS101 may be attribu-ted to the compound’s activity in the cytosol ... concomitantly with theinhibition of iNOS at that time point, prompted us tofurther explo re the mechanism of iNOS inhibition at 1h. The results of the Chi p assay revealed that treatmentwith AS101 of...
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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... outside hospitals in Norway. Emergencymedicine is not a formal speciality for doctors in Norway.Still, treatment of critically ill or injured people is definedas emergency medicine. Earlier white ... municipality withapproximately 4 000 inhabitants found an incidence of 27medical emergencies per 1 000 inhabitants per year [7].However, the definition of an emergency was wider in thisstudy than ... proportion of 45% (table 4).A29 “Breathing difficulties” was the most used Index-category in the “all other” group with nearly 5% of thetotal. Approximately half of all patients in the youngestage...
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