Báo cáo y học: "Amplification of autoimmune disease by infection" potx

... with MHV-68 in the synovium involving all cell types including fibroblasts and synovial lining cells [4]. By electron microscopy many of these cells were lytically destroyed, extracellular free ... Indeed, the lymphoid organs of Waldeyer’s ring, where EBV is thought to reactivate, are sites of Review Amplification of autoimmune disease by infection David N Posnett 1,2 and Dmit...

Ngày tải lên: 09/08/2014, 06:22

... works binding affinity of the protein to the substrate is not seriously affected, or only slightly affected, by the mutation of Gly10 to Ala or Ser, but is greatly decreased by that to Leu or Pro. The ... proteins exhibited enzymatic activ- ity. However, only the enzymatic activity of Sc-G42S* was greatly reduced compared to that of the wild-type protein. Gly42 is conserved as Gly1...

Ngày tải lên: 17/03/2014, 17:20

... J: Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet 2008, ... necessary to type so-called tag SNPs, which identify these areas of limited variability [2], to achieve good representation of the total amount of genetic variation. Most typed SNPs are...

Ngày tải lên: 09/08/2014, 14:22

... Sexually Transmitted Diseases and HIV/AIDS, National Program of HIV/AIDS, Ministry of Health and Social Development, Valencia, Venezuela, 4 Department of Biology and Society, Faculty of Earth ... University of Amsterdam, Amsterdam, The Netherlands, 5 Department of Parasitology, Faculty of Health Sciences, University of Carabobo, Valencia, Venezuela and 6 Centre of Info...

Ngày tải lên: 10/08/2014, 05:21

... whereby it i s translocated back to the cytoplasm [19,39]. While NFAT dephosphorylation is mediated by calcineurin, rephosphorylation is catalyzed by a variety of serine kinases, such as glycogen ... binding specificity of plant lectins to yeast cells by biotin-avidin system and its application to the classification of yeast cells. Anal. Biochem. 254, 41–48. 31. Na, S .Y. , Kang, B...

Ngày tải lên: 24/03/2014, 03:21

... all types of amyloid deposits [1–5]. Because of its largely unknown physiological function [6], its affinity for amyloid, and possible involvement in the pathogenesis of systemic lupus erythematosus ... the specificity of the glycosaminoglycan interaction with regard to peptide sequence by applying two additional biophysical techniques and showing that the N-terminal part of the pep...

Ngày tải lên: 31/03/2014, 23:20

... were analyzed by densitometry using Kodak Digital Science software (Eastman Kodak, Rochester, NY, USA). Data were analyzed by paired t-tests, or by analysis of variance followed by Tukey's multiple ... command of p300, because Sox9 activity was reduced by approximately 50% when NF-κB was activated. However, the demand for p300 is controlled not only by rela- tive affinity...

Ngày tải lên: 09/08/2014, 10:22

... to an attack of acute gout [29]. Erosions were detected three times more frequently by high-resolution US than on X-ray imaging. In this study, US aided in the diagnosis of gout by identifying sonographic ... study using US is the first to link the gap between asymptomatic hyper- uricemia and symptomatic deposition of urate, namely gout. Could we call this stage asymptomatic deposit...

Ngày tải lên: 09/08/2014, 14:20

... expression of a number of microRNAs. Interestingly, downregulation of miR-1, miR-133a and upregulation of miR-21 occurred by 7 days of age in these mice, long before the onset of cardiac hypertrophy, ... activity, respectively (p < 0.05, n = 3). Myocardin (MYOCD) strongly activated the mir-21 promoter activity (p < 0.05). p49 also repressed mir-21-luciferase reporter activ...

Ngày tải lên: 10/08/2014, 05:21

... anti- inflammatory agent in models of CF related inflammation mediated by NFκB. Findings Cystic Fibrosis (CF) is one of the most common lethal autosomal recessive diseases in humans. It is caused by mutations ... immortalized CF airway cell line homozygous for ΔF508 mutation and the CF 14 clinically isolated mucoid strain of PA (originally from the laboratory of Dr. M.C. Wolfgang,...

Ngày tải lên: 11/08/2014, 08:22