Báo cáo y học: "Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation" pps

... during total Table 1 Histological scoring system for cartilage repair Category Points Cell morphology Hyaline cartilage 4 Mostly hyaline cartilage 3 Mostly fibrocartilage 2 Mostly non -cartilage ... Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan 3 Section of Cartilage Regeneration, Graduate School, Tokyo...

Ngày tải lên: 09/08/2014, 10:23

... cells to undergo a Th1 to T-helper type 2 shift and increase the secretion of anti-inflammatory cytokines IL-10 and IL-4, while decreasing the secretion of proinflammatory cytokines TNFα and IL-1 ... proliferative and/ or cytokine response to +/– LEW/WKY/Wistar/F344 [20,24,30,31, Bhsp65, its arthritogenic epitope 180 to 188, or its regulatory 33,36] C-terminal determinants Incr...

Ngày tải lên: 09/08/2014, 14:22

... hyperinsulinemia, body weight, and liver enzymes. Liver steatosis and fibrosis as well as cellular infiltrates in liver and adipose tissues were analyzed by histology and immunohistochemistry. Results: ... Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010, 513948. 18. Juge-Aubry CE,...

Ngày tải lên: 11/08/2014, 03:20

... hyperinsulinemia, body weight, and liver enzymes. Liver steatosis and fibrosis as well as cellular infiltrates in liver and adipose tissues were analyzed by histology and immunohistochemistry. Results: ... fat and cholesterol (HFC) feeding as the syndrome progressed towards liver steatosis and fibrosis. We used a sensitive andhighthroughputtechnology, Taqman Low Density Array (TLD...

Ngày tải lên: 11/08/2014, 06:22

... µg lysozyme coupled to poly- L-lysine in 6 µl pyrogen-free saline into the knee joints. Histology of arthritic knee joints Total knee joints were dissected at days 3 and 7 after the onset of arthritis. ... online http:/ /arthritis- research.com/content/7/2/R392 R392 Vol 7 No 2 Research article Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocy...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 03/11/2012, 11:11

... methyl ester or the amide as acyl donor. It appeared that 6-APA and 7-ADCA were able to efficiently deacylate the phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, ... specificity constants (k cat /K m )forp-hydroxyphenylgly- cine methyl ester and phenylglycine methyl ester that were similar to the wild-type values, whereas the specificity con- s...

Ngày tải lên: 17/03/2014, 23:20

... Lombardo 2 , Antonia Follenzi 2 and Luigi Naldini 2 1 Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II; Italy 2 Laboratory for Gene Transfer and Therapy, Institute ... abnormalities, hepatosplenomegaly and neurological dysfunction. In this study, we used a late gen- eration lentiviral vector to evaluate the utility of this vector system fo...

Ngày tải lên: 24/03/2014, 04:21

... Peptide Synthesis (SPPS) in a fully automated synthesizer Syro II (Multi SynTech, Germany). For PNA synthesis, we used fluorenylmethoxycarbonyl (Fmoc)-protected monomers with the exocyclic amino ... genetic therapy approaches provide the potential to repair genetic diseases, but are limited by a poor efficiency and a lack of therapeutic safety of the commonly used delivery systems...

Ngày tải lên: 08/08/2014, 16:23

... inter- vals to maintain “hyposensitization” and to reduce symptoms due to natural exposure to the allergen. The few nasal vaccines are commer- cialized in Europe and standardized either bio- logically ... Immunotherapy for Allergic Rhinitis — Passalacqua and Canonica 121 In healthy volunteers, the allergen sprayed into the nose is slowly transported by mucociliary clear- ance to...

Ngày tải lên: 08/08/2014, 21:20