Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx

... TNF-α and IL-1β production. This study examined the hypothesis that apoA-I may have a regulatory role at sites of macrophage activation by T lymphocytes in inflamed RA synovial tissue. Synovial ... pathogenesis and the maintenance of chronic inflammation in diseases such as RA. Regulating a potent mechanism that induces both IL- 1β and TNF-α may be important in maintaining a low l...

Ngày tải lên: 09/08/2014, 01:24

... tissue events. In particular, cytokine mediated pathology may be distinct in cartilage and bone as opposed to synovial tissue or draining lymph node. For many given cytokines, establishing tissue ... of Commentary Interleukin-18: a therapeutic target in rheumatoid arthritis? Iain B McInnes, Foo Y Liew and J Alastair Gracie Division of Immunology, Infection and Inflammation, Un...

Ngày tải lên: 09/08/2014, 06:22

... antirheumatic drug (DMARD) therapy at entry and length of study. a Standard deviation not reported. ABA, abatacept; ADA, adalimumab; AIM, Abatacept in Inadequate Responders to Methotrexate; ATTAIN, ... therapeutic agents with background therapy in TNF-I-naïve patients as well as incomplete responders has characterized the safety and efficacy profile of abatacept (ATTAIN [Abatacept Tri...

Ngày tải lên: 09/08/2014, 01:22

... extraarticular RA as a whole or with particular items included in extraarticular RA. Its main findings are that shared epitope positive HLA-DR4 alleles (in this population, mostly HLA-DRB1*0401 and ... frequent in patients with purely articular RA (0.119) than DRB1*0404 (0.085), is not associated with extraarticular RA, and is not included in any of the genotypes associated with extr...

Ngày tải lên: 09/08/2014, 07:20

... hyperplasia of the synovial lining cells, inflammatory cell infiltration and angiogenesis in the sublining cell layer. Hyperplastic synovial lining cells overproduce such matrix metalloproteinases ... 5'-GGTCCCCCCACTGCTGGCCCT- TCTACGGC-3' and 5'-CACCTCCACTCCTCCCTTTCC-3' for MMP-9 (750 bp); 5'-ACATCAACGAGGGGGAGACG-3' and 5'-GGCTTCAGACAGGCAGGACA-3' for...

Ngày tải lên: 09/08/2014, 07:20

... 50:62-65. 7. Nakashima H, Inoue H, Akahoshi M, Tanaka Y, Yamaoka K, Ogami E, Nagano S, Arinobu Y, Niiro H, Otsuka T, et al.: The combination of polymorphisms within interferon-gamma receptor 1 and receptor ... analysis was 63 years (17–81 years), and 76% were female. A cohort of 171 healthy individuals matched on the basis of age, sex and origin were used as a healthy control group. All...

Ngày tải lên: 09/08/2014, 07:20

... longitudinal observational RA dataset. Data quality in this CARAbase ('CAre of RA data- base') is ensured by periodical updates of missing data by data entry personnel, as previously described ... competing interests. Authors' contributions TK performed study design, data analysis, manuscript drafting, and data acquisition. JSS and DA performed study design, data analysis, an...

Ngày tải lên: 09/08/2014, 10:20

... every year during the initial period after RA onset. Various scoring methods have been validated and established that are based on conventional radiography, the ‘gold standard’, and allow evaluation ... Stewart A, Mackenzie LM, Black AJ, Reid DM: Predicting erosive disease in rheumatoid arthritis. A longitudinal study of changes in bone density using digital X-ray radiogrammetry: a...

Ngày tải lên: 09/08/2014, 10:22

... standard for assessing structural joint damage in patients with rheumatoid arthritis (RA), is used routinely for diagnosing and monitoring RA patients, and is used as an endpoint in clinical ... sensitivity to change- dem- onstrating that the OMERACT RAMRIS system, after proper training and calibration of readers, appears suitable for use in monitoring joint inflammation and destructi...

Ngày tải lên: 09/08/2014, 10:23

... treatment. Recent analyses in a large cohort of clinical trial patients have revealed that baseline disease activity is already somewhat related to disease activity at 1 year of therapy, especially with methotrexate ... Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Morinaga T, Higashio K, Martin TJ, Suda T: Tumor necrosis factor alpha stimulates os...

Ngày tải lên: 09/08/2014, 10:23