Báo cáo y học: "Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion" potx
Báo cáo y học: "Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion" potx
... model for the cadherin adhesive interaction in
which the membrane-distal extracellular domains mediate
Commentary
Building the synovium: cadherin-11 mediates fibroblast-like
synoviocyte cell-to-cell ... pathways that determine the mesenchymal tissue
response of the synovium to inflammation.
Introduction
The synovium is a highly organized tissue that resides
between th...
Báo cáo y học: "Predicting the future of anti-tumor necrosis factor therapy" potx
... identified: a primary
phase directly after the start of treatment and a secondary
phase that develops in initial responders during the course of
therapy. The latter is explained by the formation of ... Given the destructive nature of RA, the
risk of adverse effects, and considerable costs for therapy, there is
a strong need to make predictions on success before the start of
ther...
Báo cáo y học: "Elucidating the molecular characteristics of organogenesis in human embryos" potx
... this network analysis is mostly
hypo thetical, complementary approaches such as prote-
omics, and even more importantly, hypothesis-driven
research, will be necessary to validate these results.
Human ...
types and the formation of organs - become upregulated.
During S12 to S14, structures such as the nervous system,
the heart and the somites develop further; meanwhile,
the primo...
Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... anticipated. These factors significantly
reduced the power of the study. Based on their findings, the
authors estimate that more than 100 hospitals would be
needed to show the 30% difference they sought. ...
seen from baseline to the study period for both groups
combined.
Conclusion
The MET system greatly increases emergency team calling,
but does not substantially affect...
Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... series
will probably be familiar, it is hoped that there will still be useful
lessons to be learned, for example the underlying assumptions
of a hypothesis test that were not fully appreciated, or ... some
previously unrecognised confusion between terms.
The first article, presented in this issue, covers the presentation
and summary of data. It is unlikely that the material covered by...
Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... the catalytic efficiency of the
enzyme, the cold adaptation of the enzyme could not be
attributed to the presence of the Gly cluster in this element.
The present study supports the idea that the ... Gly261 by Ala in mutant
G261A resulted in an enzyme with slightly lower stability.
On the other hand, in the double mutant G261A /Y2 69A the
additional replacement of Tyr269...
Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... guanidine hydro-
chloride (GdnHCl), urea or elevated temperatures, they
destroy the tertiary structure of proteins which results in the
loss of enzymatic activity. Regarding the secondary struc-
ture ... secondary structure only after the
disruption of the native tertiary structure of RNase A
(Figs 2–4). Interestingly, the preservation of the tertiary
structure coincides with t...
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... angle almost typical for the 3
10
helix.
In this region of the polypeptide chain, the secondary
structure is characterized also by the O
i
H
N
i þ 3
hydrogen
bonds, found in all 40
DYANA
structures ... residue for the final family is
given in Fig. S1. Fig. 3A shows the family of 40 structures
and Table 1 contains a summary of statistical data indica-
ting the quality of the 40...
Báo cáo Y học: Modeling the three-dimensional structure of H+-ATPase of Neurospora crassa Proposal for a proton pathway from the analysis of internal cavities pptx
... catalytic
activity proceed essentially by the same mechanism. Indeed,
catalytic residues occupy the same position in the 3D
structures of the two enzymes. In addition, the p redicted
secondary structures ... function,
display only one polar cavity in the vicinity of the conserved
catalytic Asp re sidue.
Keywords: neurospora; P-ATPase; homology model; cavity;
H
+
.
The 3D struc...
Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx
... previously described
[9,15]. MALDI-TOF/MS was performed on a Perseptive
DE-RP (Applied Biosystem) using a-cyano-4-hydroxycin-
namic acid as matrix.
Lethality assay in mice
The in vivo toxicity of ... venoms and
become key molecular probes for the characterization of
these channels. They are usually small basic polypeptides
(between 30 and 70 amino acids), cross-linked by three or
four dis...
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