Báo cáo y học: "TLR2 modulates inflammation in zymosan-induced arthritis in mice" docx

... mediating inflammatory responses in zymosan-induced arthritisC3 has no role in mediating inflammatory responses in zymosan-induced arthritis. (a) 99m Tc uptake measurement showed an attenuation of inflamma- tion ... peak, suggesting that ZIA has early and late phases. Histologi- cally, the joint inflammation was characterized by mononuclear cell infiltration in the sublining l...

Ngày tải lên: 09/08/2014, 06:22

... naturally occurring cells specific for self proteins or they may be induced by feeding a protein. From preliminary studies, we have results that support this suggestion, since we have seen that injection ... OVA. This finding indicates that the reduced proliferation was mainly due to the inclu- sion of OVA in the arthritogenic inoculum and not neces- sarily to events induced by OVA feeding...

Ngày tải lên: 09/08/2014, 01:23

... strain B10.Q normally show a very low incidence of arthritis (around 15%). The female predominance in incidence of CIA makes polymorphic genes in the congenic fragment particularly interesting since female ... protein kinase kinase 6 Abnormal immune system Sox9 112.643538 – 112.649074 SRY-box containing gene 9 Perinatal lethality, cartilage formation, sex reversal a Polymorfism between...

Ngày tải lên: 09/08/2014, 10:23

... actively maintained in the thymus [2]. During this process, a repertoire of T cells restricted to self-MHC displayed by the thymic cortical epithelial cells (cTECs) is selected in each individual. In addition, ... processing of Viewpoint The TRAF6-NF κκ B signaling pathway in autoimmunity: not just inflammation Ranjeny Thomas Centre for Immunology and Cancer Research, Princess Alexa...

Ngày tải lên: 09/08/2014, 06:23

... accumulation in peritoneal exudates was much lower than previously reported in other models of inflam- mation, including carrageenan-induced inflammation in the air pouch and zymosan-induced peritoneal inflammation ... receptors played similar roles in regu- lating inflammation in the peritoneum. We examined the pharmacologic mechanism by which meth- otrexate diminishes in...

Ngày tải lên: 09/08/2014, 07:20

... with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infected patients using antiretroviral ... in HIV-1-infected individuals receiving combination antiretroviral therapy. HIV Med 2009, 10:627-33. 11. Libby P, Ridker PM: Inflammation and atherosclerosis: role of C-reactive...

Ngày tải lên: 10/08/2014, 05:21

... is under stringent regulation. Tyrosine phosphorylation is a central mechanism in the control of key signaling proteins involved in innate immunity. The role of protein tyrosine kinases (PTKs) has ... the CARR-induced inflammatory pain model. A slight decrease in TNFα expression and a significant overall delayed cytokine release are detectable in PTPH1-KO mice in the early phases of...

Ngày tải lên: 11/08/2014, 03:20

... fibrosis [56]. Proinflammatory cytokines in urinary obstruction TNF-α and IL-1 The prototypical pro-inflammatory cytokines, TNF-α and interleukin-1 (IL-1), play a major role in the recruit- ment of inflammatory ... chemokines (or γ chemokines) has only two cysteines; one N-terminal cysteine and one cysteine downstream. Finally CX3C chemokines (or δ-chemok- ines) have three amino acids bet...

Ngày tải lên: 11/08/2014, 03:20

... exacerbated in genetically predisposed individuals by infection. In some cases these infections may induce an inflammatory state that protects against asthma, while in others the infection may elicit ... through interactions with intact HA in order to maintain cell integrity and decrease lung injury, but also mediate macrophage inflammatory responses to HA fragments following chemical...

Ngày tải lên: 11/08/2014, 03:20

... fibrosis [56]. Proinflammatory cytokines in urinary obstruction TNF-α and IL-1 The prototypical pro-inflammatory cytokines, TNF-α and interleukin-1 (IL-1), play a major role in the recruit- ment of inflammatory ... two N-terminal cysteines of CXC chemokines (or α-chemokines) are separated by one amino acid, C chemokines (or γ chemokines) has only two cysteines; one N-terminal cysteine and...

Ngày tải lên: 11/08/2014, 06:22